Chan Zuckerberg Biohub — 

Biologist - Zebrafish Transgenics and Light-sheet Microscopy for Cell Atlas

San Francisco, California, United States

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Lab Vision

The Discovery Machine Lab led by Loic Royer at the Chan Zuckerberg

Biohub will design and build lightsheet microscopy based ‘discovery

machines’ that will not only acquire image data, but also perform

online processing, instant 3D visualization, adaptive imaging, and

automated photo-manipulation. These integrated instruments bring

together state of the art optics, robotics, machine learning, and

image analysis with the aim of building comprehensive atlases of

development and modeling complex cellular choreographies.


We are looking for a Biologist with genetic engineering and Zebrafish

experience that will help develop Cell-Atlas related biological

projects in a collaborative environment, design experiments using

state-of-the-art light-sheet microscopy, and conceive novel labelling

strategies for live fluorescence imaging.

What we provide

• The resources to conceive disruptive technology and obtain

ground-breaking results to advance knowledge of cell biology.     

•  Collaborative environment with access to talent and resources of the

Biohub platforms  (Sequencing, Bioengineering, Genome Editing, Data

Sciences, and Advanced Imaging).     

• Access to collaborators, Resources and facilities at Stanford, Berkeley and UCSF

• Competitive compensation and benefits commensurate with experience.

• On site free snacks and beverages :-)


• Genetic engineering of novel fluorescence labelling strategies

• Transgenesis in and maintenance of model organisms (prefereably fish)     

• Fluorescent live imaging with the Lab’s custom built microscopes     

• Collaborate with Lab’s microscope designer and builder on imaging experiments     

• Collaborate with CZ Biohub’s Genome Engineering Platform     

• Collaborate with the Biohub’s DataScience Platform on image analysis 


Experience in live fluorescence microscopy and image analysis is

highly desired. The candidate should be willing to learn new skills

and knowledge, think creatively and show enthusiasm while engaging in

risky but potentially rewarding projects.


• Genetic engineering toolbox: molecular cloning, transfection,

• cloning, transfection, CRISPR-Cas, TALENs, ZFNs, Transposases,

• Recombinases… Hands on experience with zebrafish knock-ins.

• Experimental prowess in cell culture and construct engineering

• Experience in fluorescence imaging (Confocal, Light-sheet)

• Multi-color labelling strategies Live Zebrafish immobilisation

• for long term imaging


• Proficiency in Python for image processing and data analysis

• Synthetic Biology     

• Knowledge in zebrafish immunology, development and/or regeneration 

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