We are very pleased to draw your attention to a session at SETAC Europe 2019 with the title: Fish model species in human and environmental toxicology. The session is part of the main track 1-Ecotoxicology and human toxicology (from molecules to organisms, from omics to in vivo). The meeting is held in Helsinki, Finland 26-30 May 2019. Details about submitting a proposal are available on the meeting website https://helsinki.setac.org/. The deadline for abstract submission is 28 November 2018. We hope to receive many fascinating abstracts and are looking forward to a fruitful meeting in Helsinki.
Jessica, Riccardo and Jorke
Fish model species in human and environmental toxicology
CHAIRS: Jessica Legradi, Riccardo Massei, Jorke Kamstra
Fish models are commonly used in human and ecotoxicological research to investigate the impact of chemicals on whole organisms. In fact, many important biological functions are conserved between fish species and humans. Fish have a wide application domain, spanning from basic developmental biology, neurobiology, endocrinology to immunology. The small size of some available fish species including the zebrafish (Danio rerio) or medaka (Oryzias latipes) and their robust nature makes them ideally suited for application in automated high throughput screening. Furthermore, fish early life stages offer all the key attributes of a complex in vivo system (e.g. including metabolism), as well as the advantages of the in vitro assays, as tests can be conducted in multiwell plate formats with small sample volumes and run in short periods of time. These characteristics make them well suited for toxicity testing of environmental samples and to detect unknown contaminants in effect directed analysis (EDA). Research on fish over the last decade has been greatly facilitated by the increasing number of sequenced genomes, which are available for more than twelve species with more pending. This, together with recent advances in genetic and epigenetic studies, including gene knockout and transgenesis technologies, greatly facilitates the understanding of the molecular mechanisms of toxicity, making fish ideally suited for defining adverse outcome pathways (AOPs). Due to the large similarity with other vertebrates, there is also a growing interest in the application of fish model species in human disease etiology and early development. Fish early life stages have recently been used in several cancer genetics studies and drug discovery tests. In ecotoxicology, fish are also studied outside of the laboratory in their native environment. Prominent models for native fish models are roach (Rutilus rutilus) and rainbow trout (Oncorhynchus mykiss). Studying fish in their natural habitat allows to investigate further than simple dose-effect assessments. Within this session, we intend to show recent developments in toxicological research using a variety of different fish model species, novel systems, endpoints, assays and testing strategies. We will focus on molecular approaches that could lead to new AOPs. Results of toxicity studies of single stressors as well as complex environmental samples are of interest. Molecular effects, multigenerational effects, and population level impacts will be considered. We especially welcome presentations highlighting new Omics approaches for metabolomics, transcriptomics, epigenomics, proteomics and lipidomics, ideally linking these to phenotype for use in AOPs. The session will be interdisciplinary and bring together researchers across a wide range of research areas with the view to enhance approaches for studying adverse effects in human and wildlife.
PRELIM SESSION TYPE:
Platform and Poster
Dear zebrafish researchers,
My lab has generated more than 1,600 transgenic fish lines that express Gal4 in specific organs, tissues and cells, which should be potentially useful for many purposes. You may look at these expression patterns partly on the web database (http://kawakami.lab.nig.ac.jp/ztrap/). However, the database contains only a couple of side-view images that were taken by a stereoscope during our routine screening. If you are interested in particular expression patterns, I recommend for you to visit my lab, perform "shelf-screen", look at them by your eyes more precisely, and find lines that are useful for your research.
Our institute provides an opportunity to support travel expenses from foreign countries to our institute. Please look at the web site of the institute.
There are three systems. You may apply for collaborative research NIG-JOINT A (up to 200,000JPY for travel expense) or NIG-JOINT B (up to 1,000,000JPY for travel expenses and some research money) or NIG-JOINT I (up to 500,000JPY for travel expenses for foreign researchers) (B and I are a bit competitive. You may apply for A simultaneously).
The deadline of the application is 14th December, 2018.
If you are interested in this, please contact me (firstname.lastname@example.org).
Koichi Kawakami, Ph.D.
Division of Molecular and Developmental Biology
National Institute of Genetics
Margaret A. Goodell, Baylor College of Medicine
Laura A. Johnston, Columbia University
Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai
The four-day conference will:
- Bring together, for the first time, researchers from diverse fields who study competitive and cooperative interactions between cells;
- Cover recent findings on quality control systems, developing tissues, stem cell populations and tumorigenesis, as well as address important evolutionary aspects of competitive and cooperative behavior in diverse model systems;
- Define critical questions shared by the diverse investigators and help shape this exciting and emerging field.
- Scholarship Applications and Discounted Abstract – October 24, 2018
- Abstract – November 28, 2018
- Discounted Registration – January 8, 2019
For more information, please visit www.keystonesymposia.org/19B6 and for a flyer, visithttp://www.keystonesymposia.org/index.cfm?e=Web.Meeting.Flyer&MeetingID=1615.
The 8th Strategic Conference for Zebrafish Investigators (SCZI/PI meeting)
Sponsored by the International Zebrafish Society (www.izfs.org)
January 12-16, 2019
Asilomar Conference Grounds in Pacific Grove, CA
This is the meeting of zebrafish primary investigators and lab heads from around the world.
Abstracts are due October 27, 2018.
A preliminary program is available at: https://www.izfs.org/page/SCZI2019program
Keynote speakers include Ehud Isacoff of the Helen Wills Neuroscience Institute at the University of California-Berkeley and Steven Haddock of the Monterey Bay Aquarium Research Institute
Exhibit and sponsorship opportunities are available
The 2nd Italian Zebrafish Meeting will be held in Pisa from January 30th to February 1st 2019, organized by the University of Pisa, the CNR, the Scuola Normale Superiore, the Stella Maris Foundation, ISPRO and the Guido Bernardini Foundation (here the website: https://zfim2019.webs.com/).
The previous edition of this event was attended by about 200 investigators and specialists from Europe and USA.
The conference will be divided into 3 days of study and a poster area; at the end of each day there will be a debate on the topics presented, in particular focusing on the development of the zebrafish model and health issues. In addition an exhibitor area will be organized in parallel so it could be an attractive target for sponsor interaction since participants represent key decision-makers in purchasing decisions.
Please join us on October 15-18, 2018 at the EMBL-EBI campus in Cambridge/UK to learn how to analyze RNAseq data in zebrafish.
In this hands-on course, participants will learn how to design functional genomics experiments and how to manage and analyse such datasets from zebrafish and to compare these to other species. The course will be relevant to researchers working on a wide range of topics, but will use a number of cancer datasets as the basis for hands-on analysis. The final day will provide participants with an opportunity to apply the tools and resources introduced during the previous teaching sessions by undertaking a short problem solving session.
Audience: This course is aimed at researchers currently working with zebrafish and generating genomic and functional data. No prior bioinformatics knowledge is required, but knowledge of R and web-based packages would be beneficial. Trainees with limited experience of R will be provided with pre-course preparation materials to increase their R knowledge. Trainees, junior and senior group leaders are all invited to apply!
At the end of the course you will be able to:
- Design and implement RNA-Seq experiments using Zebrafish
- Know and apply common approaches and tools used in the analysis of zebrafish expression data
- Undertake basic data visualisation
- Query RNA-Seq datasets for gene signatures
- Undertake cross species comparison of gene datasets
Space is limited to 30 participants and an application process is required. Deadline is July 27, 2018
Please forward and post.
Elizabeth Busch-Nentwich (Cambridge U), Sarah Morgan (EMBL-EBI) and Kirsten Sadler (NYU Abu Dhabi)
Dear zebrafish user community,
we are proud to announce the first release of the DANIO-CODE track hub for zebrafish developmental epigenomics and transcriptomics datasets. It contains almost a 1000 tracks with 17 assay types (ChIP-seq, RNA-seq, ATC-seq, CAGE-seq etc.) from 38 stages of development. The raw data of 30 labs were annotated and reanalyzed by standardised pipelines to create the track hub, which is currently available to upload to UCSC or Ensembl genome browsers at https://danio-code.zfin.org.
For information on how to access data, on fair use policy and how to upload new data to the resource, please visit the Data Coordination Centre: https://danio-code.zfin.org.
To learn more about DANIO-CODE visit https://www.birmingham.ac.uk/generic/danio-code/index.aspx.
For enquiries on technical matters contact email@example.com.
For general enquiries contact firstname.lastname@example.org.
Please spare some time to browse the datasets and to check you favourite gene, to reveal its expression and its true promoter, to predict its enhancers and non-coding RNAs around them and many more…The first release is a beta version, please send feedback to the emails above.
Massive thank you to Matthias Hörtenhuber, Kadir Mukarram, Michael Dong and Carsten Daub at Karolinska Institutet as well as to Damir Baranasic and Boris Lenhard at Imperial College, who have been the main drivers behind the recently achieved DANIO-CODE milestone.
Thanks extend to Marcus Stoiber at Berkeley and Ben Brown at Berkeley/Birmingham for their work at the early stages of data collecting/processing pipeline development. Anne Eagle, Monte Westerfield and their colleagues at ZFIN for hosting and managing the datasets and WIKI, Matthias Hörtenhuber, Julia Horsefield (Otago), Bernard Peers (Liege) and Shelley Jukes (Birmingham) for helping with management and Fiona Wardle (KCL), Boris Lenhard for their major contributions in lobbying/applying for funds and DANIO-CODE meeting organisations. Further acknowledgements goes to all the data producers (see DCC) particularly those, who submitted unpublished data: Elisabeth Busch-Nentwich (Sanger), Antonio Giraldez (Yale), Tatjana Sauka-Spengler (Oxford), Jose Louis Gomez Skarmeta (UPO Sevilla) and their colleagues. Finally, we need to acknowledge the financial support by the European Commission’s H2020 Marie Sklodowska-Curie programme to ZENCODE-ITN and the BBSCR, UK.
We hope this achievement will not only help in learning about the zebrafish genome, it will also motivate all of us to submit additional, published and unpublished datasets to keep this resource growing for the benefit of the user community.
Again, huge thanks to those who did this great job and wishing you as much fun as we have had with browsing the datasets in their full glory:).
On behalf of DANIO-CODE and ZENCODE-ITN partners
Ferenc Mueller email@example.com
The Chinese zebrafish research community has been rapidly growing in recent years. Since 2012, the Chinese Zebrafish Principal Investigator Meeting (CZPM) has been held in Wuhan by the China Zebrafish Resource Center (http://zfish.cn). The CZPM is a biennial meeting series for scientists who are interested in basic and applied science in zebrafish and other fish models.
The 4th CZPM will take place from October 11th to 14th, 2018. The organizers welcome all participants who wish to take this opportunity to exchange research results, to share ideas, and to promote collaborations.
For more information, please visit the meeting website: http://pi2018.zfish.cn/ .
Yonghua Sun, Institute of Hydrobiology, Chinese Academy of Sciences
Feng Liu, Institute of Zoology, Chinese Academy of Sciences
Zhan Yin, Institute of Hydrobiology, Chinese Academy of Sciences
Anming Meng, Tsinghua University
We are happy to inform you that registration for the Nordic Zebrafish and Husbandry meeting is now open. The deadline for registration is the 8th of October 2018. You are invited to submit abstracts for either the oral or poster presentation. The participation fee is 1000 SEK and includes all coffee breaks, lunches and the dinner/social event.
For more information, please visit the meeting website:
We look forward to seeing you in Stockholm in November 2018!
For a workshop, sponsored by ORIP/NIH end of July, we are seeking community feedback to discuss and assess the needs and challenges of developing defined diets and optimized feed management strategies that will support normal zebrafish development and physiology and will facilitate the analysis of phenotypes in a standardized nutritional environment. This will promote rigor and reproducibility in some zebrafish studies and enhance the use of zebrafish and other aquatic models in biomedical research.
A more detailed description of workshop purpose and objectives is below. The organizers would very much appreciate your thoughts on the issue. Please provide your feedback through this survey:
Workshop Organizing Committee (WOC) members:
Diana Baumann (Stowers Institute for Medical Research, MO)
Lilianna Solnica-Krezel (Washington University School of Medicine, MO)
John Rawls (Duke University School of Medicine, NC)
Robert Tanguay (Oregon State University, OR)
Zoltan Varga (ZIRC, University of Oregon, Eugene, OR)
Stephen A. Watts (Chair; University of Alabama at Birmingham, AL)
Follow this link to the Survey:
Or copy and paste the URL below into your internet browser:
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Workshop: Defined Diets for Zebrafish and Other Aquatic Biomedical Research Models: Needs and Challenges
ORIP/DPCPSI/OD-NIH sponsored Workshop
Purpose of the Meeting: Aquatic animal species, such as zebrafish (Danio rerio), are powerful models for studying human development, behavior, genetics, and disease. The ability to produce transgenic and mutant lines provides biomedical researchers with many options for developing models of human diseases and for developing relevant therapeutic approaches. Different facilities and laboratories use a variety of diets and feeding protocols to maintain these models. In many laboratories zebrafish are reared with a combination of live feed (ex vivo) and/or one of many undefined commercial diets. Commercial diets used in zebrafish husbandry differ significantly in ingredient and nutrient composition and often contain preservatives, lakes, dyes, antinutritional factors, or bioactive food compounds. Studies indicate that the length, weight, sexual maturation, fecundity, and mortality of zebrafish can vary significantly with different diets. Unfortunately, impacts of diet on zebrafish health and behavior and corresponding implications for zebrafish research outcomes are not well described. Currently, the daily dietary nutrient requirements of almost all nutrients have not been investigated. There is also no consensus among aquatic facilities, researchers, and commercial vendors on nutritional requirements at various life stages (i.e., larval, juvenile, and adult) or for particular research applications to minimize husbandry variations among aquatic facilities or laboratories. Complicit in this lack of consensus is a community-wide lack of understanding of the role of nutrition in animal development, health, and research outcomes. To address this gap, the Office of Research Infrastructure Programs (ORIP) is sponsoring a workshop to bring together members of the zebrafish scientific community, with expertise in zebrafish and other aquatic and relevant models, for a day of discussion. The workshop attendees will assess the needs and challenges of developing defined diets and optimized feed management strategies that will support normal zebrafish development and physiology and will facilitate the analysis of phenotypes in a standardized nutritional environment. Standardization and education will promote rigor and reproducibility in some zebrafish studies and enhance the use of zebrafish and other aquatic models in biomedical research.
- Review diet development strategies, where available, in other biomedical model species.
- Assess the current nutrition status of zebrafish.
- Describe the need for defined diets for maintenance and experimental stocks, including assessment of life stage requirements.
- Discuss the potential impact of defined diets on genetic stocks used in biomedical research, their effect on development, physiology and expressivity of disease/mutant phenotypes.
- Identify obstacles and evaluate strategies that may lead to a successful consensus, acceptance, and implementation of defined diets among the different scientific community stakeholders.
- Define an educational approach to informing the community and associated partners (journals, organizations, granting agencies, etc.)
- Determine whether/how the approach to develop a defined diet for zebrafish could be applied to other aquatic models, and animal models in general.
In ophthalmology, clinician scientists may be unaware of the many possibilities provided by zebrafish models. On the other hand zebrafish researchers may be unexposed to pressing clinical research questions. The aim of the meeting is to bring researchers using the zebrafish model closer to the medical community. At the same time, the meeting shall introduce the virtues of the zebrafish model to clinical researchers. Keynote lectures will cover various aspects of zebrafish eye research. This will be complemented by presentations addressing research on human eye diseases with high clinicial relevance. In addition, short talks and poster presentations will be selected from submitted abstracts of meeting participants.
International Zebrafish Conference
June 20-24, 2018
Feeling depressed that you missed the deadline and won’t have the opportunity to join all your fishy friends and colleagues at the “big meeting” in Madison? Well cheer up - you’ve got a second chance!!
Late registration and abstract submission* are now open for the International Zebrafish Conference being held in Madison, Wisconsin, June 20-24, 2018.
The meeting includes:
30+ plenary, concurrent, and poster sessions showcasing the latest zebrafish research
* Note that late abstracts can only be considered for poster presentations
Click HERE to register** and/or submit an abstract**
**In order to register for the conference and/or submit an abstract, you must sign in or create a new IZFS website profile. During profile creation you will also be given the opportunity to become an IZFS member, giving you access to discounted IZFS member conference registration rates. If you have trouble creating a profile, contact our administrator at firstname.lastname@example.org