2 postdoctoral positions are available in laboratory of Kaska Koltowksa at the Department of Immunology, Genetics and Pathology (IGP) at Uppsala University.
The University is one of the top universities in Sweden and well recognised world-wide. There are many high-quality departments at the University, including my host Department: Immunology, Genetics and Pathology (IGP). IGP is known for its excellence in multidisciplinary research as it consists of divisions covering a wide spectrum of research areas. The Vascular Biology programme is part of IGP, and hosts world-leading vascular biologists. Such strong expertise in vascular biology in one place is unique to Uppsala University, and provides an excellent working environment.
Our research group studies lymphatic vessel formation in zebrafish, as a main model system. Lymphatic vessels are predominantly derived from a defined venous, vascular network, posing an intruding question of how cells know to form one vasculature from another. The overarching goal of my lab is to broaden our understanding of how lymphatic vessels form and establish function; and apply this knowledge to the development of new therapeutics. To achieve this my lab will focus on two major areas: (1) Understanding lymphatic specification and (2) Transcriptional control of lymphangiogenesis.
Zebrafish are an excellent model organism that allow the study of how these processes happen in real time, in an embryo. Using elegant genetic models, we can dissect the molecular factors that drive organogenesis. The main techniques used in the lab include advance microscopy, RNA sequencing, mutant and transgenic line generation.
We are a young lab that is currently supported by multiple Swedish funding agencies.
For further details visit:
Applicants should be highly motivated and passionate about scientific research, possess a
PhD degree, and strong track-record with peer-reviewed publications.
Position 1: Expertise in molecular and cellular biology, genetics techniques and animal models. Good knowledge of microscopy.
Position 2: Expertise in bioinformatics, large data set analysis including RNA sequencing. Knowledge in biology will be a strong advantage.
How to apply:
Please apply by sending short motivation letter (including research interest and career goal), CV, contact details for three references to: firstname.lastname@example.org
A post-doctoral Research Associate position is available in the Kucenas Lab in the Department of Biology at the University of Virginia to study the role of glial-glial interactions in nervous system development and regeneration. Currently in the lab, we are investigating: 1) the development and maintenance of nervous system transition zones, 2) the molecular mechanisms that mediate glial tiling, 3) elucidating the glial heterogeneity present in both the CNS and PNS and 4) the role of glia in nervous system disease and regeneration. For more information about the lab, please visit our website: www.kucenaslab.com. This position, supported by the Owens Family Foundation and the NIH, involves basic and translational research using zebrafish and we are seeking an enthusiastic, focused and creative candidate to join our team.
Our lab is located in the Physical & Life Sciences Building at UVa in Charlottesville, Virginia and is within a 10-minute walk of the Medical Center, which provides exceptional opportunities for collaboration among basic and clinical scientists. Our scientific community is heavily invested in training, and we work hard to help trainees develop the skills necessary for successful independent careers.
Candidates must have a Ph.D. in Neuroscience or a related discipline (i.e. Biology, Cell and Developmental Biology, etc.) by the start date of this position. The incumbent will have demonstrated expertise in molecular biology techniques including DNA methodologies, PCR, gene silencing and imaging. Candidates must have proficiency in spoken and written English.
This is a one-year appointment; however, appointment may be renewed for an additional two one-year increments, contingent upon available funding and satisfactory performance.
To apply, visit http://jobs.virginia.edu and search on Posting Number 0623517. Complete a Candidate Profile online, attach a cover letter, curriculum vitae and contact information for three references.
Review of applications will begin July 1, 2018; however, the position will remain open until filled.
Questions regarding the position and application process should be directed to Rich Haverstrom at email@example.com.
The University will perform background checks on all new hires prior to making a final offer of employment.
The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.
In Vivo Analysis of Dynamic Cell Behaviors and Cell-Cell Interactions Underlying Blood Vessel Formation
We are inviting applications for a:
PhD position in Molecular Mechanisms of Vascular Morphogenesis at the Biozentrum, University of Basel
A PhD position is open in the Focal Area Growth and Development in the research group of Prof. Markus Affolter.
We offer an exciting international research environment at the Biozentrum in Basel to study the morphogenetic mechanisms of blood vessel formation in vivo. By using novel genetic approaches combined with high-resolution confocal live-imaging we are investigating the mechanisms of junctional remodeling during sprouting angiogenesis in the zebrafish embryo. The PhD project will involve the generation of tissue specific and inducible knock-out models in zebrafish and state-of-the-art in vivo imaging approaches to dissect protein dynamics during endothelial cell movements and cell-cell interactions.
We are looking for highly motivated candidates with a solid background in genetics, molecular biology and cell biology. Experience working with zebrafish is desired but not mandatory. Fluency in spoken and written English is required.
For further information, please refer to the following publications:
or consult the web pages of Prof. Markus Affolter
Starting date by arrangement. Salary according to institutional guidelines. Please send a CV, a brief description of previous research experience and the names of three refer-ences to Dr. Heinz-Georg Belting (firstname.lastname@example.org).
A postdoctoral fellowship/senior research associate position is currently available in the Bonkowsky lab at the University of Utah in Salt Lake City, UT. As a senior research associate there is an opportunity for long-term faculty or staff appointment.
The project entails the use of zebrafish as an experimental model to study and develop human leukodystrophies, with extension to drug discovery and testing in other systems. We apply advanced genetic approaches, including transgenesis, genome editing (CRISPR/Cas9), optogenetics, behavior screening, and confocal microscopic imaging techniques (e.g. Gao et al., eNeuro, 2018; Strachan et al., Human Molecular Genetics, 2017; Son et al., Nature Scientific Reports, 2016).
Our research group is an interdisciplinary, collaborative group with research interests ranging from studies of connectivity, effects of hypoxia, and the leukodystrophies and human disease genes. The Bonkowsky laboratory is located in the Department of Neurobiology with access to a large modern zebrafish facility, imaging core facilities, and a vibrant scientific community including more than ten zebrafish labs.
Candidates should have a Ph.D. or other advanced degree in a research field. The ideal candidate will have expertise in bench research, microscopy, data and/or image analysis, and modern molecular biology techniques.
If interested, please send your CV to: Josh Bonkowsky, MD, PhD (email@example.com)
GRANT- PAID JOB OPPORTUNITY
POSTING NUMBER: GPD-18038
POSTING DATE: June 18, 2018
CLOSING DATE: June 25, 2018
Manager, Zebrafish Core Facility
Medical Research Development Office
The Zebrafish Core Facility (ZCF) provides state-of-the-art infrastructure, as well as services and training for researchers, at Dalhousie Faculties, and other institutions. The facility has capacity for approx. 60,000 fish and currently maintains more than 100 wildtype and genetically modified zebrafish lines. The Manager position is a full-time, term position. The Manager will be expected to provide all necessary expertise in biomedical zebrafish aquaculture and management of a large and complex aquatics facility. The Manager ensures a high standard of service support to researchers and a high quality of care to the animals in accordance with Canadian Council on Animal Care guidelines.
This position reports operationally to the Chair of the Zebrafish Oversight Committee and administratively to the Manager of Operations. This position will be part of a family of advanced research facilities (Centralized Operations of Research Equipment and Supports or CORES). More information about CORES can be found at: http://medicine.dal.ca/research-dal-med/facilities.html.
- Daily management of the facility including direct supervision of technical and student personnel
- Oversight, operation and troubleshooting of associated facility infrastructure and equipment
- Provide leadership and direction regarding new techniques and services that can be offered to users
- All aspects of zebrafish colony management including: breeding schemes and colony size, tracking strain data including phenotype characteristics, pedigrees and generation #, breeder rotation, performance issues, etc.
A detailed job description is available on request.
Qualifications: A minimum BSc (with MSc preferred) in Biology or related field, plus at least two years' experience working in a zebrafish facility. Experience in animal husbandry and management of a large and complex aquatic facility utilizing recirculating systems is essential. In addition, website maintenance and specialized knowledge in biomedical zebrafish use, molecular and cryopreservation techniques and CRISPR is preferred. Must be able to work independently, as well as have excellent organization and communication skills. Some basic electrical and plumbing knowledge would be preferred. Job duties require flexible hours and working a rotating weekend schedule. This position also receives emergency after hour's calls and responds to facility alarms.
Status: 40 hours/week
Pay Scale: $55,000
Duration: 1 year term with possibility of renewal
Deadline for application: June 25, 2018
Interested parties should forward a cover letter and current CV to:
Director, Research Development
Only applications submitted directly to the e-mail address above will be considered. We thank all applicants, however, only candidates selected for an interview will be contacted.
Dalhousie University is committed to fostering a collegial culture grounded in diversity and inclusiveness. The university encourages applications from Aboriginal people, persons with a disability, racially visible persons, women, persons of minority sexual orientations and gender identities, and all candidates who would contribute to the diversity of our community. For more information, please visit www.dal.ca/hiringfordiversity
A little bit about us
Dalhousie University is Atlantic Canada’s leading research-intensive university and a driver of the region’s intellectual, social and economic development. Located in the heart of Halifax, Nova Scotia, with an Agricultural Campus in Truro/Bible Hill, Dalhousie is a truly national and international university, with more than half of our 18,500 students coming from outside of the province. Our 6,000 faculty and staff foster a vibrant, purpose-driven community, that’s celebrating 200 years of academic excellence in 2018.
Chan Zuckerberg Biohub —
Biologist - Zebrafish Transgenics and Light-sheet Microscopy for Cell Atlas
San Francisco, California, United States
Apply for this job here:
The Discovery Machine Lab led by Loic Royer at the Chan Zuckerberg
Biohub will design and build lightsheet microscopy based ‘discovery
machines’ that will not only acquire image data, but also perform
online processing, instant 3D visualization, adaptive imaging, and
automated photo-manipulation. These integrated instruments bring
together state of the art optics, robotics, machine learning, and
image analysis with the aim of building comprehensive atlases of
development and modeling complex cellular choreographies.
We are looking for a Biologist with genetic engineering and Zebrafish
experience that will help develop Cell-Atlas related biological
projects in a collaborative environment, design experiments using
state-of-the-art light-sheet microscopy, and conceive novel labelling
strategies for live fluorescence imaging.
What we provide
• The resources to conceive disruptive technology and obtain
ground-breaking results to advance knowledge of cell biology.
• Collaborative environment with access to talent and resources of the
Biohub platforms (Sequencing, Bioengineering, Genome Editing, Data
Sciences, and Advanced Imaging).
• Access to collaborators, Resources and facilities at Stanford, Berkeley and UCSF
• Competitive compensation and benefits commensurate with experience.
• On site free snacks and beverages :-)
• Genetic engineering of novel fluorescence labelling strategies
• Transgenesis in and maintenance of model organisms (prefereably fish)
• Fluorescent live imaging with the Lab’s custom built microscopes
• Collaborate with Lab’s microscope designer and builder on imaging experiments
• Collaborate with CZ Biohub’s Genome Engineering Platform
• Collaborate with the Biohub’s DataScience Platform on image analysis
Experience in live fluorescence microscopy and image analysis is
highly desired. The candidate should be willing to learn new skills
and knowledge, think creatively and show enthusiasm while engaging in
risky but potentially rewarding projects.
• Genetic engineering toolbox: molecular cloning, transfection,
• cloning, transfection, CRISPR-Cas, TALENs, ZFNs, Transposases,
• Recombinases… Hands on experience with zebrafish knock-ins.
• Experimental prowess in cell culture and construct engineering
• Experience in fluorescence imaging (Confocal, Light-sheet)
• Multi-color labelling strategies Live Zebrafish immobilisation
• for long term imaging
• Proficiency in Python for image processing and data analysis
• Synthetic Biology
• Knowledge in zebrafish immunology, development and/or regeneration
Apply for this job here:
An immediate postdoctoral or a research technician position is available in the group of Prof. Sean Sun at the Whiting School of Engineering at Johns Hopkins University. The position involves research with the electric eel, electrocytes and engineering of microfluidic devices. Experiences with fish cell biology, fish stem cells and tissue culture are highly desirable. The position is for 2 years with the possibility of renewal. For additional information, please inquire at firstname.lastname@example.org. Applicants should send CV and 3 letters of reference to
Sean Sun, PhD (email@example.com)
Mechanical Engineering and Biomedical Engineering
Johns Hopkins University
Two NIH-funded post-doctoral positions are available immediately in Robert Cornell’s Laboratory of the Department of Anatomy and Cell Biology at the University of Iowa Carver College of Medicine in Iowa City, Iowa.
The research goals of our laboratory are to understand the gene regulatory networks that govern lineage specification and terminal differentiation during embryonic development, as well as those that govern homeostasis in adult stem cells. We study melanocytes (with relevance to melanoma and general questions of stem-cell biology), periderm cells (with relevance to cleft palate), and dopaminergic neurons (with relevance to Parkinson’s disease). In these efforts we primarily use zebrafish and cell culture models, and we collaborate with mouse biologists.
List of publications from the Cornell group:
One project focuses on the transcription factor TFAP2A. Our research questions relate to: how it regulates the timing of the switch between stasis versus growth and differentiation in melanocyte stem cells; what role it plays in making chromatin accessible for transcription; and how it interacts with KCTD15 in regulating transcription in melanocytes. This project is a collaboration with Deborah Lang at Boston University and Trevor Williams at the University of Colorado, Denver.
A second project focuses on the pathological mechanisms whereby common and rare genetic variants contribute to risk for orofacial clefting. This project applies reporter assays to zebrafish, human cell lines, and mice, as well as high-throughput sequencing approaches (ATAC-seq, 5C) to primary and cultured cells. This project is a collaboration with Elizabeth Leslie at Emory University and Axel Visel at the Lawrence Berkeley National laboratory.
Recent PhD or MD/PhD in genetics, developmental biology or biochemistry.
Strong experience in molecular biology.
Highly motivated, enthusiastic, and creative candidate with excellent interpersonal skills and a strong publication record.
Experience with bioinformatics is desirable.
Experience with zebrafish is not necessary.
To apply for this position visit our website at http://jobs.uiowa.edu; requisition #2986. Candidates will need to provide:
A cover letter describing accomplishments and interest in the laboratory’s research projects
Contact information for three references
The University of Iowa is an Equal Opportunity/Affirmative Action Employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. Applicants’ credentials are subject to verification.
Position Type: Postdoctoral Position at the NIH
Position Title: OPTIMIZING PRECISE GENOME-EDITING METHODS IN ZEBRAFISH
The NICHD Zebrafish Core and NICHD Molecular Genomics Core are seeking a postdoctoral researcher to commence no later than September 2018 on a joint project to optimize precise genome-editing methods in zebrafish. In the first phase under Dr. Benjamin Feldman’s mentorship at the NICHD Zebrafish Core, previously described CRISPR/Cas9-based strategies for generating amino-acid coding substitutions in endogenous genes will be applied to loci with orthology to human disease-causing genes under study in NICHD’s Division of Intramural Research. In the second phase under Dr. Steven Coon’s mentorship at the NICHD Molecular Genomics Core, frequency of targeted alterations for the above methods and loci will be compared using NextGen sequencing. In a third phase working with both cores, a NextGen-sequencing based method for economically identifying infrequent germ-line transmitters will be developed and potential zebrafish disease models will be recovered. The NICHD and NIH offer an exceptional postdoctoral training environment through its collegial, supportive and rigorous approach to scientific research, its access to state-of-art equipment and resources, and its world-class seminar series.
This position requires an individual with a recent PhD and substantial experience and skills in (1) experimental design and troubleshooting, (2) molecular biology (cloning, PCR, etc.), (3) microscopy and fine-scale manipulation (needed for microinjection and handling of zebrafish embryos) and (4) bioinformatic and computational analysis of DNA sequence. Experience working with a small animal model is also desirable, though not essential.
Please email a CV, the names of three references, and a cover letter briefly describing research experience, interests, and career goals to the contact information below.
Benjamin Feldman, Ph.D.
Director of the NICHD Zebrafish Core
Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD)
Bethesda, MD 20892
Employer Name: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE FOR CHILD HEALTH AND HUMAN DEVELOPMENT
Position Location: Main NIH campus, Bethesda, MD
Application Deadline: July 7th, 2018
The NIH is dedicated to building a diverse community in its training and employment programs.
Neuronal specification in the zebrafish spinal cord
Department of Biology, Syracuse
University, New York
Posting #: 75246
Applications are invited for a lab technician position to work in the Lewis Lab at Syracuse University.
Our research focus is examining the genetics of how different types of spinal cord nerve cells are made
The ideal candidate will have a bachelors degree or equivalent experience, prior molecular biology
experience, excellent organization skills and be extremely reliable, a quick learner and able to work
independently. This position will involve mainly genotyping but also some zebrafish husbandry and other
lab tasks as required. A strong understanding of genetics is crucial. Training in particular techniques will
be provided as needed.
A one-year minimum commitment is required. Benefits information (non-exempt employees category)
can be found at http://humanresources.syr.edu/benefits/
Applicants should fill in the job application at http://www.sujobopps.com/postings/xxxx and include a
cover letter stating why they are interested in the position, a full CV and the names, phone numbers and
email addresses of at least three referees, at least one of which should be a prior employer.
Informal enquiries can be addressed to firstname.lastname@example.org.
Closing date: July 5th 2018
(If the job is not filled at this stage – new applications will be considered. Please see website to check if job is still open)
Only short-listed applicants will be contacted. Interviews are likely to be in July.
The SU Biology department (biology.syr.edu) is a vibrant department with strengths in Developmental
Biology, Neuroscience, Genetics, Epigenetics, Ecology and Evolution.
Syracuse is an inexpensive, very pleasant and vibrant city to live in. It offers the amenities of a city
without lots of the hassles. It has its own airport (15 minute drive from downtown) and is close to
Toronto, New York City, Philadelphia and Montreal as well as the natural beauty of Upstate New York
(Niagara Falls, The Finger Lakes, Adirondack lakes and mountains etc).
Syracuse University also shares a campus with SUNY Upstate Medical University that has active research
programs in Cell Biology, Developmental Biology and Neuroscience and the Lewis Lab regularly
participates in seminar series and other programs with SUNY UMU researchers.
The Varshney lab is recruiting for a highly motivated, passionate and independent individual with excellent interpersonal skills to play a key role in advancing the mission of the lab.
BA/BS degree in one of the biological sciences, physics, or chemistry or 4 years of professional, paid relevant laboratory experience. Should be familiar with lab techniques.
Apply developing knowledge to coordinate day-to-day work, complete a variety of detailed tasks and assignments. Basic knowledge of Internet software, order processing system, data base and Microsoft Office software. Must be detail oriented and work independently as well as a team player.
Ability to read and comprehend instructions, short correspondence and protocols/procedures. Ability to write routine reports and correspondence. Ability to compute basic mathematical operations, i.e., rate, ratio, percent, molarity, and unit conversion. Ability to organize and perform precise and accurate work when dealing with samples and chemicals.
Ability to speak effectively to present ideas and data analysis to supervisor, who will decide how to proceed. Suggest changes to experiments and procedures. Ability to exchange ideas and procedures with co-workers and other labs.
One or more years of relevant lab experience. Experience in one or more of the following areas is preferred but not required: molecular biology (e.g., cloning and PCR), cell culture, protein biochemistry, mass spectrometry, microbiology/sterile techniques, microscopy.
Typically Monday through Friday, 8:30am to 5pm
Regularly required to stand, use manual dexterity, talk or hear; Frequently required to walk and reach with hands and arms; occasionally sit; frequently lift and/or move up to 50 pounds; vision abilities include close vision, color vision, depth perception and ability to adjust focus.
Potential exposure to fumes, airborne particles, or rodent dander. May work with toxic, caustic chemicals, radioactive materials, liquid nitrogen, human tissue or blood. Potential risk of electrical shock. Occasional exposure to cold 4C, and/or extreme cold -80C from freezers. Noise level is usually moderate.
Apply online at http://apptrkr.com/1234383
Postdoctoral Fellow Position in Zebrafish Drug Discovery / Neuroscience - St. Michael’s Hospital
Position: Postdoctoral Fellow
Location: Keenan Research Centre for Biomedical Science
Reports to: Principal Investigator
Hours: 37.5 hours / week
Status: Full-time, two-year contract
Salary: $40,000 - $50,000 + benefits + vacations + health insurance
A postdoctoral position is available in the Brain & Breathing Science Lab at the Keenan Research Centre for Biomedical Science at St. Michael’s Hospital (www.gasplab.com).
Our lab focuses on understanding the neural mechanisms underlying opioid-induced respiratory depression using rodent models and at finding novel therapies to prevent opioid overdoses using zebrafish. The Brain & Breathing Lab is collaborating with the Zebrafish Centre for Advanced Drug Discovery.
We are currently looking for a postdoctoral fellow to help establish a new, phenotype-based high-throughput platform in zebrafish to identify target genes and new drug compounds that could prevent respiratory depression with opioid overdose, while preserving the analgesic properties of opioids.
- Implement, test, and enhance our existing platform in zebrafish.
- Test chemical libraries such as FDA-approved and repurposing drug libraries.
- Develop gene screening approaches in zebrafish to identify key-genes involved in the regulation of breathing in zebrafish
- A recently obtained PhD in Drug and/or Gene Discovery in Zebrafish and Neuroscience.
- Experience and expertise with zebrafish, genes knockdown with morpholino oligonucleotides, and drug screening
- Relevant first-author publications.
- Excellent skills in scientific writing and verbal presentation in English with a recent publication track record
- Expertise in Neuroscience is preferred but not mandatory.
- Please do not apply if your PhD is not related to zebrafish or drug screening.
Submit/attach a complete application as a single PDF file including 1) curriculum vitae, 2) one-page statement describing applicant’s accomplishments, 3) copies of relevant in-press, submitted articles, 4) names and email addresses of 3 referees.
Submit application to email@example.com
Thank you for your application, only those selected for an interview will be contacted.
Closing date. June 30, 2018.
A postdoctoral fellowship/senior research associate position is currently available in the Mchaourab lab at Vanderbilt University in Nashville, TN. The project entails the use of zebrafish as an experimental model to understand the proteostasis network in the lens and heart. We apply advanced genetic approaches, including transgenesis and genome editing (such as CRISPR/Cas9), and microscopic imaging techniques to decipher the functional roles of small heat shock proteins for the maintenance of transparency during lens aging as well as stress resistance of the heart. Our recent discovery revealed a direct coupling between proteostasis and cortisol stress signaling (Mishra et al., 2018, JBC; Wu et al., 2016, JBC) and future directions will seek to investigate the mechanistic bases of this coupling.
We are a highly interdisciplinary group with research interests ranging from chaperones to multidrug transporters. The Mchaourab laboratory is located in the Department of Molecular Physiology and Biophysics with readily access to many state-of-the-art cores in fluorescence microscopy, mass spectrometry and various biophysical instrumentation. The position will provide opportunities for applying mechanistic biochemistry in vitro to complement the in vivo genetic analysis as well as learning advanced biophysical techniques.
Candidates should have a Ph.D. in Biochemistry, Cell Biology, Genetics, or related fields. The ideal candidate will have expertise in microscopy, image analysis, and modern molecular biology techniques, with previous experience in zebrafish rearing and husbandry.
If interested, please send your CV to: Hassane S. Mchaourab, Ph. D. (firstname.lastname@example.org)
Postdoctoral positions are available in the Parichy lab at University of Virginia. The lab studies development using zebrafish and related species. Current emphases include hormonal control over post-embryonic neural crest stem cells, plasticity in cell state, evolution of novel cell types, and mechanisms of pattern formation and cell–cell communication within zebrafish and across Danio species. Methods include super-resolution time-lapse imaging on lab-dedicated microscopes, single cell RNA-sequencing, forward and reverse genetics, conditional manipulation of gene activity, and others. Examples of recent work include:
The Parichy lab is situated in a highly interactive department with state-of-the-art facilities and UVA has outstanding current and historical strengths in morphogenesis and pattern formation.
Applicants must have or be pursuing a Ph.D. and must have experience with modern methods of developmental biology. Prior experience with zebrafish is not required.
Applicants should submit the following to Dr. David Parichy (email@example.com):
• contact information for three references
• brief description of interests, experience and career goals
Applications are invited for the post of Postdoctoral Research Associate
within the Bateson Centre and the Sheffield Institute for Translational
Neuroscience (SITraN) at the University of Sheffield. We are seeking a
highly motivated scientist with experience in zebrafish research and
neurobiology to work on an exciting new, MRC-funded project which will
establish the mechanistic role of susceptibility genes for Parkinson’s
disease using mutant zebrafish (Danio rerio) lines. Funding for this
postdoctoral position is initially available for 30 months.
Genetic studies have greatly improved our understanding of monogenic forms
of Parkinson’s disease (PD), however this only accounts for 5-10% of PD.
Genome-wide association studies (GWAS) have also identified 24 risk loci in
the much more common sporadic form of PD. In the Bandmann lab we are
interested in the function of these genes that have been identified as risk
factors and have developed a large number of mutant zebrafish lines using
CRISPR/Cas9 in order to study them. Many of these genes have not previously
been studied in vertebrate models or result in embryonic lethality making
zebrafish an ideal model system in which to study them.
You will be undertaking in vivo pathway analysis on these already
established lines to determine whether these genes are involved in
pathobiological pathways linked to PD. A concept of distinct pathobiological
mechanisms contributing to PD is emerging and is centred around
mitochondrial dysfunction, autophagy/lysosomal dysfunction, and
neuroinflammation and the innate immune system. You will combine
neurophysiological, biochemical, morphological and functional analyses with
comparative, RNA-seq based transcriptomic studies to characterise these
mutants. This will establish the mechanistic role of the selected PD GWA
genes, provide new insight into the pathogenesis of PD and identify
potential drug targets.
You will have excellent skills relevant for zebrafish research along with a
PhD (or equivalent experience) and ideally also a strong background in
Neurobiology. You will join an internationally recognised research group in
a vibrant and stimulating environment within the Bateson Centre and SITraN.
This post is full time, fixed term for 30 months.
Please see for further details:
Informal enquiries to:
Prof Oliver Bandmann, firstname.lastname@example.org