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One postdoctoral position is available at the Nicoli Lab, Department of Internal Medicine and Pharmacology, Yale University, New Haven, CT USA.

The goal of our laboratory is to combine zebrafish genetics, genomics and live-microscopy to uncover RNA-based mechanisms controlling cardiovascular function. Our laboratory contributes to vascular, developmental biology and miRNAs functions (Dev. Cell 2017, SciReports 2016, Dev. Cell 2015, Cell Reports 2015). To see full profile visit our web site at nicolilab.com.


Projects available for the candidate:

1) Define RNA-based regulations occurring during mechanotransduction. Mechanism and phenotype related to cardiovascular tissue mechanics will be prioritized.

2) Phenotypic and functional analysis of multigene miRNA family zebrafish mutants in vivo and in vitro. Phenotypes related to hematopoiesis, vascular remodeling, lymphatic developments and neurovascular unit function will be prioritized.


Candidates with excellent molecular biology and microscopy skills will be considered. Computational skills are preferable but not necessary. Candidates are required to have strong interpersonal skills and outstanding written and spoken English to collaborate with a diverse team of scientists. Qualified candidates should have recently accomplished their Ph.D. degree (possibly no more than 1 year).


Candidates should send their Curriculum Vitae and a cover letter summarizing:

- A description of their accomplishments.

- Their research interests in RNA and/or Development and/or Vascular Biology.

- Contact information for three references to:

 Stefania Nicoli, Ph.D. stefania.nicoli@yale.edu

 

We are pleased to announce the availability of two fellowship positions for post-doctoral (PhD) and clinical (MD) fellows wishing to train in the broad area of heart failure. We seek applicants who are motivated, demonstrate a desire to succeed, and have a long-term commitment to cardiovascular research in an academic environment. This is an ideal opportunity to obtain scientific publications and intellectual development that will lay the foundation for future successful professional development as an independent scientist. UAB's well-established NIH-funded investigators will provide a mentored experience critical to early career development. We are interested in a number of animal models which include zebrafish. Previous experience in heart biology is not necessarily required.

 

Eligibility: 

* In good standing at current institution;

* No more than 5 years since having received most recent high level degree (i.e., PhD or MD);

* US citizens or permanent residents;

* Express a long-term plan and expectation to work as an independent investigator in cardiovascular research broadly related to heart failure;

* Commit to meet all obligations of the training program (detailed information to be provided at later date).

 

For those with interest in the zebrafish model, please contact Dr. Stephen A. Watts at UAB (sawatts@uab.edu)

 

Fellowship Positions - UAB Post-Doctoral Training in Basic and Translational Science in Heart Failure (T32HL129948)

 

DATE: April 24, 2017  

We are pleased to announce the availability of two fellowship positions for post-doctoral (PhD) and clinical (MD) fellows wishing to train in the broad area of heart failure. We seek applicants who are motivated, demonstrate a desire to succeed, and have a long-term commitment to cardiovascular research in an academic environment. This is an ideal opportunity to obtain scientific publications and intellectual development that will lay the foundation for future successful professional development as an independent scientist. UAB's well-established NIH-funded investigators will provide a mentored experience critical to early career development. We are interested in a number of animal models which include zebrafish. Previous experience in heart biology is not necessarily required.

 

Eligibility: 

* In good standing at current institution;

* No more than 5 years since having received most recent high level degree (i.e., PhD or MD);

* US citizens or permanent residents;

* Express a long-term plan and expectation to work as an independent investigator in cardiovascular research broadly related to heart failure;

* Commit to meet all obligations of the training program (detailed information to be provided at later date).

 

For those with interest in the zebrafish model, please contact Dr. Stephen A. Watts at UAB (sawatts@uab.edu)

An NIH-R01 funded postdoctoral fellow position is available immediately in the laboratory of Dr. Ellen Lien to study coronary and cardiac lymphatic vessel development and heart regeneration. We have demonstrated that zebrafish is an excellent model to study coronary vessel development and re-vascularization during heart regeneration (Harrison et al. Dev. Cell 2015). For this specific position, the candidate will use zebrafish, cell culture, and/or mice to elucidate molecular mechanisms of coronary/cardiac lymphatic vessel development and the roles of coronary and lymphatic vessels in heart regeneration. A background in molecular biology, genetics and/or cell biology is required. Previous experience with generating transgenic and CRISPR mutant zebrafish is preferred but not required. Experience in performing in situ hybridization and/or cell culture is also preferred. Our laboratory is part of the large community of stem cell and regenerative medicine research at University of Southern California and Children’s Hospital Los Angeles and we encourage multidisciplinary approach and interactions. We provide excellent salary, benefits and career development opportunities. Please send CV and names and contact information of 3 references to:

 

Ching-Ling (Ellen) Lien, Ph.D,

Associate Professor

Keck School of Medicine

University of Southern California

Saban Research Institute

Children’s Hospital Los Angeles

4650 Sunset Blvd. MS#137

Los Angeles, CA 90027

Phone: 323-361-8377

Email: clien@chla.usc.edu

http://keck.usc.edu/pibbs/dsr/faculty/Ching-Ling-Lien/

We have a position open immediately for post-doctoral fellow to join our laboratory to investigate the pathophysiology of genetically-defined blood diseases in both zebrafish models and cell lines. The newly constructed and fully-equipped lab consists of 750 sq ft aquatic facilities and 600 sq ft bench space including advanced Zeiss microscopy. There is additional 1500 sq ft of lab space for non-zebrafish related studies.

Experience in molecular biology (genotyping, qPCR, cloning) and zebrafish manipulation is highly desired. Expertise in cellular metabolism or RNA splicing would be great.

Postdocs will be expected to participate in project planning, recording, and interpretation of data, and communication of results, and be expected to give poster sessions and oral presentations at national meetings. The successful applicant will be a team player, work independently but with regular communication with the principal investigator, lead zebrafish scientist, and team. He/she will have strong data analysis and writing skills.

Richmond is one of the most affordable large size cities, with low cost of living, wonderful outdoors activities (kayaking, biking, and hiking), and microbrewery scene. Virginia Commonwealth University is the #1 public arts school in the US. It is also close to Washington, the Atlantic Ocean, and some of the country’s best vineyards.

Please send CV, names of three references, and career statement to Seth Corey, Professor of Pediatrics, Micro/Immunology, and Human and Molecular Genetics at VCU, seth.corey@vcuhealth.org

A Ph.D. scholarship offered to an exceptional student, to investigate genetic mechanisms which underpin vertebrate birth defects, with a particular focus on craniofacial defects such as cleft palate.

This scholarship will be offered to an independent, proactive, forward thinking and enthusiastic candidate, who wishes to forge an independent career in science.

Applicants should have a high level of achievement, including a first class honours degree or equivalent.

As an applicant you should have an interest in developmental genetics and understanding the processes which govern embryo formation, as well as a keen interest and aptitude in biochemistry and molecular genetics. Your project will address biological and cellular behaviours which regulate how the vertebrate embryos forms, using the mouse, and zebrafish as genetic developmental models.

Benefits of the scholarship include:

  • a La Trobe Research Scholarship for three years, with a value of $26,288 per annum, to support your living costs [2016 rate]
  • a fee-relief scholarship (LTUFFRS) for four years to undertake a PhD at La Trobe University (international applicants only)
  • opportunities for authorship on high impact scientific manuscripts.
  • opportunities to attend national and international conferences
  • opportunities to work with La Trobe’s outstanding researchers, and have access to our suite of professional development programs

 

How to Apply:

  • Review how to apply for a graduate research scholarship at: http://www.latrobe.edu.au/research/future/apply
  • Contact Dr. Seb Dworkin by email at s.dworkin@latrobe.edu.au, with a full CV, academic transcript, and a cover letter outlining why you would like to be considered for this scholarship.
  • Dr. Dworkin, and the Department of Physiology, Anatomy and Microbiology will carefully review your application and consider you for this Scholarship.
  • The successful applicant who receives in-principle agreement for supervision, will then submit a complete PhD application to the La Trobe Graduate Research School, attaching a copy of the agreement to Admissions.grs@latrobe.edu.au

 

Closing date - Applications close 1 July 2017, unless filled sooner. You will be advised of an outcome by 31st July, 2017.

Contact us - If you require further information, please contact: s.dworkin@latrobe.edu.au or the La Trobe University Graduate Research School: grs@latrobe.edu.au

PhD studentship available

Please follow the link for a PhD opportunity in the Whitfield lab, fully funded by the BBSRC.  This four-year project involves GPCR drug discovery in the zebrafish model, and will include a 3-month placement in a company.  For further information, please contact Tanya Whitfield (t.whitfield@sheffield.ac.uk).  Entry is for October 2017.  Deadline for applications: Friday 26th May 2017. 

https://www.sheffield.ac.uk/bms/research/whitfield#tab03

Postdoctoral Research Associate position is available in the Hoffman Lab at the Yale Child Study Center (www.hoffmanlab.net). We use zebrafish as a translational tool to investigate the function of genes that are strongly associated with autism spectrum disorders (Hoffman et al. 2016 Neuron). Specifically, we use CRISPR-generated zebrafish mutants to study how disruption of autism risk genes affects the developing brain and the neural circuitry underlying simple behaviors. Our goal is to utilize this system to identify basic mechanisms underlying autism and potential new pharmacotherapies.

Candidates must have a Ph.D., M.D., or M.D./Ph.D. in Neuroscience, Genetics, or Cell and Developmental Biology. The ideal candidate will have demonstrated expertise in standard and advanced molecular biology techniques, developmental neurobiology, and microscopy. Special consideration will be given to applicants with experience using animal models of human genetic disorders. Candidates should be highly motivated, enthusiastic, learn quickly, have a strong work ethic, and a high degree of independence.

Please send your CV, a cover letter stating your research interests and professional goals, and the contact information for three (3) references to Dr. Ellen Hoffman (ellen.hoffman@yale.edu).

A postdoctoral position is available at the Vanderbilt Eye Institute to work on an NIH-funded project investigating a novel a zebrafish and mouse models of glaucoma.  Retinal pathology will be investigated by immunohistochemistry of retinal whole mounts, histology of optic nerves and axonal transport assays.  Visual function will be analyzed by optokinetic assay.   The project includes pharmacological studies of a novel treatment for glaucoma.  Additional zebrafish models will be generated using Crispr/Cas9.  Similar experiments will be carried out in a parallel mouse model.  Vanderbilt Eye Institute, located in Nashville TN, offers a highly collaborative and resource-rich environment.  The ideal candidate would have training in eye research, including in some of the techniques outlined above.  Molecular biology experience is a plus.  Candidates with a PhD in Visual Science, Neuroscience, Biomedical Engineering or related field with experience in eye research preferred.  To apply, please send a cover letter , CV and list of references to:  Dr. John Kuchtey at: john.kuchtey@vanderbilt.edu.

 

Job Requirements:

Excellent communication skills

Ability to work independently and collaboratively

 

At least some of the following skills:

Eye research using zebrafish and/or mouse

Immunohistochemistry, microscopy and image analysis

Behavioral assays of visual function

Molecular biology, Crispr/Cas9 mutagenesis

Eawag, the Swiss Federal Institute of Aquatic Science and Technology, is an internationally-networked aquatic research institute within the ETH Domain (Swiss Federal Institutes of Technology). It conducts research to achieve the dual goals of meeting direct human needs for water and maintaining the function and integrity of aquatic ecosystems.

The Department of Environmental Toxicology (Utox) of Eawag is offering a position for a

Postdoctoral Researcher in Behavioral/Molecular Toxicology

The increasing occurrence of contaminants in aquatic ecosystems has become an environmental issue of global concern. Yet, mechanisms of toxicity and molecular targets are unknown for most contaminants, complicating the prediction of their impact on aquatic biota and aquatic ecosystems. We aim to elucidate molecular mechanisms of toxicity of a wide range of contaminants using the zebrafish as model, which is amenable for the mechanistic dissection of complex processes. In our lab, we are combining molecular tools with behavioral analysis and imaging techniques to further our mechanistic understanding of the effects of environmental contaminants on aquatic organisms.

The postdoctoral researcher will be involved in developing a new approach to identify molecular targets and toxicity pathways of a given chemical. A key step in this approach will be to establish a method to sort zebrafish larvae into different sensitivity classes after chemical exposure based on their behavioral output. Further molecular analysis will be done using mainly transcriptome profiling techniques. The duration of this employment is initially for two years with the possibility for extension. The starting date is as soon as possible.

We are looking for a motivated scientist holding a PhD with experience in working with zebrafish and in behavioral analysis. A strong interest in environmental toxicology, experience in transcriptomics, molecular biology and robust statistical and computational skills will be a strong plus. Creativity and independent thinking are critical requirements for this project.

Eawag offers a unique research and working environment and is committed to promoting equal opportunities for women and men and to support the compatibility of family and work. Applications from women are especially welcome. For more information about Eawag and our work conditions please consult www.eawag.ch and www.eawag.ch/en/aboutus/working/employment.

For further information about the position and the project please contact:
Dr Colette vom Berg-Maurer, Email colette.vomberg@eawag.ch.

The closing date for applications is 31 May 2017. The position will remain open until a suitable candidate is found. Your application should include a CV, a motivation letter and the names and contact information of three references.

We look forward to receive your application through this webpage, any other way of applying will not be considered. Please click on the link below, this will take you directly to the application form.

https://hr.refline.ch/673277/0519/pub/index.html

Postdoctoral position-Biomechanics of Vascular Development-University of Pittsburgh

 

An NIH R01-funded postdoctoral position is available immediately in the laboratory of Dr. Beth Roman in the Department of Human Genetics at the University of Pittsburgh. This position provides an outstanding opportunity for cross-disciplinary training at the interface of physics and human health, requiring close collaboration with the laboratories of Dr. Lance Davidson (Bioengineering) and Dr. Andrew Hinck (Structural Biology). We are looking for a productive, highly motivated scientist to dissect the interaction between bone morphogenetic protein (BMP)/ALK1 signaling and mechanical force in controlling directed endothelial cell migration, using zebrafish and endothelial cell culture models. Our ultimate goal is to understand how ALK1 signaling disruption in the genetic vascular disorder, hereditary hemorrhagic telangiectasia (HHT), causes arteriovenous malformations (AVMs). AVMs are direct connections between arteries and veins that can lead to hemorrhage and stroke.

The University of Pittsburgh is a collaborative, collegial environment for biomedical research. Our laboratory is part of a large, interactive zebrafish community, and we are affiliated with the Heart, Lung, and Blood Vascular Medicine Institute (VMI), which houses numerous laboratories focused on basic and translational cardiovascular research. Our laboratory is also integral to the UPMC/Pitt HHT Center of Excellence, affording the opportunity to translate research findings to a clinical care setting. 

Qualified candidates must have a PhD in biology, bioengineering, or other relevant field, a strong publication record, and excellent oral and written English communication skills.  Expertise in fluid mechanics and endothelial cell culture is preferred. Previous experience with zebrafish, dynamic live-cell imaging, confocal microscopy, and image analysis is desired. Interested candidates should send a brief cover letter (maximum 1-page) summarizing scientific accomplishments and outlining motivation for this position, a CV, and full contact information for three professional references to Dr. Beth Roman at romanb@pitt.edu.
 

For more information, please see

http://www.publichealth.pitt.edu/home/directory/beth-l-roman

http://www.upmc.com/Services/hht/Pages/default.aspx

http://www.vmi.pitt.edu/

 

 PhD studentship in 'Liver formation: dissecting mechanisms of organ size control in development and regeneration’

PHD PROJECT Investigating “how progenitor cells monitor and control organ size during normal growth and during regeneration following liver injury” is offered by the Ober group at the Danish Stem Cell Centre (DanStem). The position is for a predoc/research assistant in the first year subsequently appointed as PhD fellow, (1+3).

 

DanStem is an international research center at the University of Copenhagen addressing basic research

questions in stem cell and developmental biology. It currently encompasses eleven research groups bringing

together international experts in cell biology, genetics, transcription and stem cell biology, associated in

particular with visceral organ development and homeostasis. Any student hired under this project will be

enrolled into DanStem’s PhD program.

 

This position will be part of StemPhys an interdisciplinary initiative joining stem cell biology and theoretical

and experimental physics aiming to significantly advance our understanding of stem cell commitment, fate

differentiation and organ formation. Details can be found at www.stemphys.ku.dk 

 

The position in the Ober group is available from July 2017 for four years.

 

The PhD project will be based within the Ober group and use a variety of approaches, such as new genetic

tools and zebrafish mutants, live-imaging and genome-wide transcriptome analysis, as well as mathematic

modeling and biomechanic analyses by collaboration within StemPhys to address fundamental questions of

organ formation in vivo.

 

Details can be found at: http://employment.ku.dk/phd/?show=905878

Postdoctoral position-  The Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, invites applications for a postdoctoral position.  We are seeking highly motivated candidates to join translational research projects in human and medical genetics and the development of zebrafish, mouse, and cellular models of metabolic, cardiovascular, and neurodegenerative disorders.  Applicants should have an M.D. and/ or Ph.D. and a strong background in human genetics or molecular and cellular biology.  Please send CV, a statement of research and career goals, and names and contact information of three references to:

genetics@temple.edu

PhD position available in the Aging and Muscle Metabolism Lab, University of Lausanne, Switzerland

Mitochondrial fate in aging muscle and exercise

 

Introduction

The University of Lausanne (UNIL) hosts 14’100 students and nearly 3’800 collaborators, professors, and researchers. Ideally situated at the banks of Lake Geneva, near Lausanne’s city center, its four campuses bring together more than 120 nationalities and are embedded in the larger, regional, vibrant life science research cluster.

 

Presentation

To complement the research activities in the Aging and Muscle Metabolism Lab at the Department of Physiology of the University of Lausanne, we are seeking to recruit a PhD student to work on projects relating to novel mitophagic pathways during aging, particularly looking into muscle wasting and adaptations to exercise.

 

Job information

Expected start date in position: as soon as possible

Contract length: 1 year, renewable

Activity rate: Full time position (approximately 50% for thesis, the rest shared among other projects & teaching)

Workplace : University of Lausanne, Department of Physiology

 

Your responsibilities

The main responsibility consists in conducting scientific research in the framework of the Amati lab, which is to investigate novel proteins and pathways that play a role in muscle metabolic dysfunctions that come with aging or with muscle wasting (myopathies). Mitochondria are key players in muscle metabolism and associated dysfunctions. Finely tuned dynamic modulations adapt the number of these organelles, as well as their function, location and architecture in response to external stimuli. We and others highlighted the role of mitochondria turn-over to maintain their efficiency in skeletal muscle. Autophagy-mediated degradation (referred as mitophagy) appears crucial to face muscle stimulation, stress and aging processes. The proposed project will build on findings that we have made on specific proteins and pathways that could play a role not only in aging, but also in muscular diseases such as myopathies and muscular dystrophies. The project will start on one targeted protein identified as a potentially novel mitophagic player. It will entail state of the art methodology based on multidisciplinary approaches, including clinical research, molecular biology, cellular biology and in vivo models. This project will be part of the larger mission to identify new molecular actors and pathways involved in mitochondria structuration and mitophagy. Developing zebrafish model and human primary muscle cells, we combine innovative tools to explore the functions of our hit candidates.

Of note, we are also open to new research ideas that collaborators wish to bring into the lab – with regard to both the experimental and the clinical side of the lab’s activities.

Funding for the positions is available, although application to personal, international fellowship programs will be encouraged.

 

Your qualifications

The ideal candidate should be a highly motivated scientist and critical thinker with a Master degree in biology or related discipline. Good team player with a solid theoretical and practical knowledge of molecular biology, cell biology and physiology. A basic knowledge of genetic model, particularly zebrafish, will be an advantage. Excellent spoken and written English is an indispensable requirement. Willingness and interest in developing a PhD thesis in the broader fields of translational research/molecular biology is a necessity.

 

Your benefits

The Amati lab, also known as the Aging and Muscle Metabolism lab, is hosted at the Department of Physiology at the University of Lausanne, a well-equipped and well-funded institute (https://www.unil.ch/physiologie/home.html). Our group benefits from a dynamic environment and strong collaborations embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), high end institutional facilities (cellular imaging, proteomics, electron microscopy, etc) and multiple biotech companies. We offer a nice working place in a multicultural, diversified and dynamic academic environment.

The PhD student will be enrolled in the Faculty of Biology and Medicine's doctoral school (https://www.unil.ch/ecoledoctoralefbm/en/home.html).

 

For informations

Lab website https://www.unil.ch/physiologie/home/menuinst/groupes-de-recherche/francesca-amati-1.html

 

Your application

To apply, please send a single PDF file including a motivation letter describing why you are interested in joining our group, a CV including scientific publications if applicable, your Bachelors/Masters grades, and contact details for 2 or more referees to francesca.amati@unil.ch. Please also state where you have seen the call for this position.

Deadline for application: May 30, 2017 

Langenau Laboratory Research Fellowship in Pediatric Cancer and Zebrafish Models                  

The Langenau Laboratory at the Massachusetts General Hospital, Boston is recruiting research fellows to study mechanisms of progression and relapse in T and B cell leukemia and rhabdomysorcoma – a tumor of muscle.  Research will focus on using the zebrafish genetic model, biochemistry, and cross-species bioinformatics approaches to identify novel pathways that drive progression and relapse. Following discoveries made in the zebrafish model, work will continue in characterizing discoveries in human cell culture, primary patient samples, and mouse xenograft studies.

Dr. Langenau’s research group has become a pioneer in the field and made seminal discoveries using the zebrafish model.  The laboratories interests are best summarized in the following manuscripts (Tenente et al., Elife 2017; Moore et al., JEM, 2016; Tang et al., Nature Communications, 2016; Blackburn et al., Cancer Cell 2014; Tang et al., Nature Methods, 2014; Chen et al., PNAS 2014; Ignatius et al., Cancer Cell 2012).  Additional information about the laboratory is available at langenaulab.com.

Applicants with advanced skills in in vivo microscopy, mouse xenograft transplantation, stem cell biology, muscle development, leukemia, blood development, bioinformatic analysis, and biochemistry (including ChIP seq) are highly desired. Background in zebrafish development and/or cancer is not required.

Candidates must have PhD and/or MD, have made significant scientific contributions through publication of high impact papers, and be enthusiastic about science.

A curriculum vitae, list of publications, and three references should be emailed as a single PDF by May 25, 2017 to dlangenau@mgh.harvard.edu and ssmith6@partners.org.

 

Langenau Research Group

Molecular Pathology Unit

Massachusetts General Hospital

149 Thirteenth Street, Room 6133

Charlestown, MA 02129