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Our Company

NemaMetrix Inc. is a fast-paced, biotechnology company whose mission is to enable scientists and researchers around the world to better understand human health by offering a more affordable and accessible platform. We develop solutions for the genetic modification of C. elegans and D. rerio (Zebrafish) to act as human proxies for disease research and drug discovery and help our customers reveal new insights into the true nature of genetic mutations.  

NemaMetrix is headquartered in Eugene, Oregon with a satellite office located in Salt Lake City, Utah.


Role: Molecular Biology Scientist

Location: Eugene, OR

Overview:

Working as part of our Research & Development team, this role’s principal focus is to deliver the necessary biological constructs, such as plasmids, to downstream teams for the creation and ultimate analysis of transgenic C elegans and Zebrafish. The incumbent will oversee most of the day to day lab activities including scheduling, daily/weekly prioritization, data collection, reprocessing, training, development of and adherence to SOPs, maintenance requests, and related activities.

What You’ll be Doing:

  • Designing and generating constructs for CRISPR mediated insertion of disease relevant genetic mutations, transgenic reporters and protein tags into model organisms, primarily Zebrafish.

  • Applying standard and advanced molecular biology techniques for detecting precise edits in vivo (insertion & integration).

  • Generation and propagation of de novo genome edited animals.  

  • Identifying and troubleshooting innovative technologies to validate design and capture integration events.

  • Working independently and within a team to meet commercial project schedules, to optimize timelines and increase workflow of the engineering pipeline.


What You Bring to the Table: NemaMetrix is looking for individuals that possess a positive can-do attitude, are motivated by doing a job well, are adaptable and flexible, have a continuous improvement mindset and will thrive in a fast-paced collaborative and diverse environment. In addition, successful candidates will have the following:


Required Qualifications

  • PhD in Molecular Biology or a related field; Or BS or MS with 8+ years of experience.

  • Hands on experience with CRISPR genome editing methodologies, specifically with zebrafish.

  • Demonstrated success with site directed mutagenesis and homology driven repair.

  • Functional knowledge of advanced homology based cloning methods such as Gibson Assembly, Golden Gate or Infusion.

  • Proficient in standard molecular and biochemistry analysis.

  • Ability to design and build plasmids and transgenic constructs.

  • In-vitro transcription and RNA purification.

  • DNA and RNA Sequence Analysis.

  • Zebrafish Husbandry and Genotyping experience.


Preferred Qualifications

  • Proficiency with Morpholino design and microinjection

  • Familiarity with the tol2 transposon system

  • Molecular Phenotyping using qPCR analysis

  • Experience with Western Blotting, specifically in Zebrafish

  • Ability to design and interpret High Resolution Melting (HRM) analyses

  • Clinical Genetics experience


Perks of Working with Us

In addition to our friendly and collegial staff, NemaMetrix offers a benefits package that includes:

  • Medical, Dental, Vision and Life/AD&D insurance

  • 401k plan

  • Paid Time Off

  • Flexible work schedules

  • Employee Events – including Summer BBQs, community service and holiday related events.

  • Dog friendly work environment in our Eugene, OR office


Our Commitment to You

NemaMetrix is an equal opportunity employer. NemaMetrix recruits, employs, trains, compensates and promotes individuals regardless of race, religion, color, national origin, sex, disability, age, sexual orientation, gender identity, veteran status, and any other protected category as required by applicable law.

Our dedication to promoting diversity, multiculturalism, and inclusion is clearly reflected in our content and across all our efforts. Diversity is more than a commitment at NemaMetrix—it is the foundation of what we do. We are fully focused on equality and believe deeply in diversity of all the fascinating characteristics that make us different.

We are looking for a qualified and experienced research technician with expertise in zebrafish husbandry, breeding, egg injection, morpholino oligonucleotides, genotyping, histology, and behaviors. A recently graduated MSc or PhD student who studied zebrafish and neuroscience is preferred. 

We are looking for a Canadian or a permanent resident living in Ontario. Applications from non-Canadians or non-permanent residents will not be considered.

If selected, you will be part of the Brain & Breathing Science lab at the Keenan Research Centre for Biomedical Sciences at St. Michael's Hospital and University of Toronto. Information can be found here: www.gasplab.com

The position comes with health, dental benefits and may be long-term position depending on the fit.

If you are motivated, fun and independent, do not hesitate to send us a cover letter and resume at gasp.lab@gmail.com


Thanks for your interest.

Gaspard Montandon

The Frazer lab at the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City seeks a post-doctoral fellow. We study lymphoblastic leukemias & lymphomas using zebrafish models and in vitro tissue culture, with emphasis on the genetic events underlying oncogenesis and therapy resistance. My lab belongs to the Depts. of Pediatrics, Cell Biology, and Microbiology & Immunology, and the OUHSC Stephenson Cancer Center, and we have 7 full-time members.


A fun, motivated, independent, and creative person is a perfect fit for our group. I am committed to mentoring you to achieve your career goals. Projects you develop as a post-doc can be taken upon leaving the lab. Applicants need a PhD and/or MD, and experience with zebrafish, genetics, and/or molecular biology are plusses.


OUHSC has a large campus with multiple schools (graduate, medical, dental, allied-health, nursing, etc.). Our lab is well-equipped, with strong core facilities available. We have an aquatic facility manager who coordinates fish care, breeding, IVF, etc., so you can focus on experiments.


Oklahoma City is the 27th largest US city (~1.3 million people) and Oklahoma’s capital. It has diverse cultures & ethnicities, as does our lab. OKC’s cost of living is very low, so post-docs can live well here. Please contact me by email & attach your CV if you’d like to discuss the position further.

We are looking for a highly motivated and dynamic researcher for a one year position, to commence Jan. 1st, 2020. 

 

Our research
Our main research interest is molecular and genetic mechanisms of cardiac development and congenital heart disease. We are using a multidisciplinary approach, where we combine genetic and genomic investigations of patients, with functional investigations based on embryonic tissues, cell models and zebrafish. Our ambition is to perform research on the highest level and publish in high-quality international journals. We have a very inclusive working environment and a large network of national and international collaborators. More information about our research can be found at:

https://icmm.ku.dk/english/research-groups/la-larsen-group/

 

Information on Department of Cellular and Molecular medicine can be found at: https://icmm.ku.dk/english/

 

Your job
Your project will focus on functional characterization of candidate disease genes identified in patients with congenital heart defects. Preferably, the functional characterization of cardiac developmental genes should be performed using zebrafish and cell models. Consequently, the project will include standard methods for gene targeting in zebrafish (i.e. morpholino and CRISPR-cas9 based gene targeting) and phenotypic characterization of heart defects. Thus, documented expertise in zebrafish developmental biology will be an advantage.

 

Detailed information about the position, including how to apply,  can be found at: https://employment.ku.dk/all-vacancies/?show=150510

 

For further information please contact Prof. Lars Allan Larsen (larsal@sund.ku.dk).

A postdoctoral position at the University of Pittsburgh to study the expression regulation of polarity genes in zebrafish

 

We are looking for a self-motivated postdoc to study the expression regulation of polarity genes by using recombinant DNA technologies, RNA and DNA FISH, immunohistochemistry, confocal microscopy, and transgenic zebrafish etc. Candidates should have a PhD in developmental biology, genetics, molecular biology, or cell biology. Applicants shall send a cover letter and a CV to Dr. Xiangyun Wei atweix@upmc.edu (Xiangyun Wei, Ph.D., Associate Professor, University of Pittsburgh School of Medicine, Pennsylvania, United States)

 

It is highly recommended that the applicants discuss his or her research interests on Wei labs publications by email. Five representative papers are listed as follows:

 

Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.B., Sun, M., Wei, X. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience. 3:63-85 

 

Fang, W., Guo, C., Wei, X. (2017) Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(11):2834-2848

 

Zou, J., Wang, X., and Wei, X. (2012) Crb Apical Polarity Proteins Maintain Zebrafish Retinal Cone Mosaics via Intercellular Binding of Their Extracellular Domains. Developmental Cell. 22(6):1261-1274 

 

Wei, X. and Malicki, J. (2002) nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nature Genetics. 31(2):150-157 

 

X. Wei, J. Samarabandu, R.S. Devdhar, A. Siegel. R. Acharya, R. Berezney. (1998) Segregation of transcription and replication sites into higher order domains. Science. 281:1502-1505.

The Buckley lab at the department of Physiology, Development and Neuroscience (PDN), University of Cambridge is recruiting a Research Assistant or Research Associate to help further develop their optogenetic technology. The lab uses optogenetic and live confocal imaging approaches within the whole zebrafish neural tube and mammalian embryo stem cell (mESC) culture to manipulate the polarity of single cells. In combination with CRISPR-mediated functional knock down experiments, we are directly testing the role of cell polarity in building epithelial integrity during organ development and breaking in it during normal developmental processes such as EMT and during abnormal disease states.
The post is for 1 year in the first instance from early 2020 and funding is available for potential contract extension.

For full details see: https://urldefense.com/v3/__http://www.jobs.cam.ac.uk/job/23220/__;!5W9E9PnL_ac!UCzkYjy_WRtKNktAf9V1IVKWiZBnx8kwF7Mum7_CakV9Q5TJ9Ey9tkZJ9VW9iy8J$
Informal enquiries can be addressed to Dr Clare Buckley at ceb85@cam.ac.uk.

Leukodystrophy Disease Pathology and Therapeutics

A position for a postdoctoral fellow is available for studies on leukodystrophy disease gene pathophysiology and therapeutics discovery in the Bonkowsky lab (http://medicine.utah.edu/pediatrics/labs/bonkowsky/). The experimental model systems include mouse, zebrafish, and human (see paper by Strachan et al., 2017, Human Molecular Genetics).  Projects in gene therapy and small molecule development are part of the project.

Qualifications:  PhD or MD/PhD. Strong background and experience in experimental sciences (such as molecular biology and/or biochemistry) is necessary.  Prior experience in genetics, developmental biology, neuroscience, sequencing, programming, and imaging would be advantageous. Experience in animal models of disease strongly recommended. 

Candidates should be ambitious and independent with good communication skills and team mentality; and at least one first-author publication in a well-respected journal.

The lab and setting are an innovative, well- equipped and scientifically stimulating surrounding.  Initial employment and funding contract is for one year (renewable) with standard NIH pay scale.  Applicants should be able to apply for external (NIH or private foundation) funding.

Women and under-represented minorities are especially encouraged to apply.  The University of Utah is an Equal Opportunity Employer.  

Applications should include a ½ page letter of description of their research interests and career goals, a CV, and the names and contact information of three academic references, and be sent to:

Dr. Josh Bonkowsky

E-Mail: joshua.bonkowsky@hsc.utah.edu


The Francis Crick Institute    

Early Career Group Leader programme


The Francis Crick Institute is a new biomedical discovery research institute in central London dedicated to understanding the biology underlying health and disease.

We are core-funded by Cancer Research UK, the Medical Research Council, and the Wellcome Trust.

Explore the Crick's research interests at https://www.crick.ac.uk/research


We seek creative and innovative individuals to establish new research programmes in:


All areas of biology and biomedicine (of particular interest are cancer and immunity and infection)

We are also looking for people interested in cardiac and vascular biology (special initiative, supported by the British Heart Foundation)


The Crick research environment

  • 120 research laboratories
  • Comprehensive Science Technology Platforms (STPs)
  • Animal husbandry and imaging
  • 250 graduate students, 400 postdocs


 

Our Package

  • Initial 6-year contract, renewable, to total 12 years
  • Salaries and consumables for up to five researchers, including graduate students
  • Opportunity to expand through external grant funding
  • Ready access to Crick STPs
  • Full lab setup in state-of-the-art laboratory space
  • Package applies to duration of contract



Further information on Early Career Group Leaders can be found at:

https://www.crick.ac.uk/careers-and-study/faculty

Apply online at: https://academicrecruitment.crick.ac.uk

Informal enquiries about The Francis Crick Institute or the application procedure can be made at: Group-leader-recruitment@crick.ac.uk


Applications by midnight (GMT), 10th October 2019

(Recruitment symposia in December and January 2020)


The Department of Biological Sciences, University of Toronto Scarborough (UTSC) invites applications for a tenure-stream appointment in the area of Zebrafish Biology. The appointment is at the rank of Assistant Professor and will commence on July 1, 2020, or shortly thereafter.
Candidates must have a PhD in the Biological Sciences or a related field, at least one year of postdoctoral experience, an outstanding research record and a strong commitment to excellence in teaching at the undergraduate and graduate levels. The successful candidate must use zebrafish to study fundamental biological questions using the latest technological approaches. We are particularly interested in candidates who will create synergies with existing zebrafish research within the department and will complement and deepen our existing departmental strengths. Research areas and technological approaches of the successful candidate may include, but are not limited to:
- Developmental Neurobiology
- Behavioral Neuroscience
- CRISPR/Cas9 disease modeling
- Use of genomic and transcriptomic approaches

The successful candidate will be expected to conduct innovative and independent research at the highest international level and to establish an outstanding, competitive, and externally funded research program. Applicants must have a record of excellence in research, as demonstrated by publications in top ranked and field-relevant academic journals, presentations at significant conference, awards and accolades for work in the field, an innovative research statement and strong endorsements by referees of high international standing. The successful candidate will also have a strong commitment to excellence in teaching at both the undergraduate and graduate level. A commitment to excellence in teaching will be demonstrated through the statement of teaching philosophy, teaching accomplishments, and evidence of superior performance in teaching-related activities documented in the submitted teaching materials. Documented teaching excellence may include performance as a teaching assistant or course instructor, experience leading successful workshops or seminars, student mentorship, or conference posters or presentations, as well as strong letters of reference. The successful candidate is also expected to show evidence of a commitment to equity, diversity, inclusion, and the promotion of a respectful and collegial learning and working environment, demonstrated through the application materials. Salary will be commensurate with qualifications and experience.

Further information on the research and teaching activities of the department can be found at https://urldefense.com/v3/__http://www.utsc.utoronto.ca/*biosci/__;fg!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2mZJfs2N$ .

The University of Toronto is an international leader in biological research and education and the Department of Biological Sciences enjoys strong ties to other units within the University. The successful candidate will cross appointed to the Graduate Department of Systems and Cell Biology at the University of Toronto (https://urldefense.com/v3/__http://csb.utoronto.ca/__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2j43ksy8$ ), and expected to maintain an active research program centered at the University of Toronto Scarborough, and to foster and facilitate inclusivity while working in one of Canada's most diverse institutions. At UTSC, the new faculty member will have access to several research facilities including state of the art molecular, cellular, neuroscience, and imaging tools in the Centre for the Neurobiology of Stress (https://urldefense.com/v3/__https://www.utsc.utoronto.ca/cns/__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2ri2q7t5$ ) and the outstanding chemistry analytical capacity offered by the TRACES Lab (Teaching and Research in Analytical Chemical and Environmental Science -https://urldefense.com/v3/__http://www.utsc.utoronto.ca/*traceslab/__;fg!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2o89mD_P$ ).

All qualified candidates are invited to apply at this link . Applications must include a current CV, a cover letter, a statement of research, three representative publications, a statement of teaching philosophy, and other teaching materials showing evidence of excellent performance in teaching related activities as listed above. Submission guidelines can be found at: https://urldefense.com/v3/__http://uoft.me/how-to-apply__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2mJzFBPZ$ . We recommend combining attached documents into one or two files in PDF/MS Word format. Applicants must also arrange that letters of reference (on letterhead, signed and scanned) from at least three referees familiar with the candidate’s research and teaching be emailed directly by the referee to: biologygeneral@utsc.utoronto.ca by the closing date. Applications lacking reference letters will not be considered. If you have questions about this position, please email biologygeneral@utsc.utoronto.ca. All application materials, including reference letters, must be received by December 2, 2019.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see https://urldefense.com/v3/__http://uoft.me/UP__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2rZPVte_$ . All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.


Full Time, 2 years. 

Salary: According to experience

Closing Date: 30th of October 2019

Starting Date: 1st February 2020



A postdoctoral position is open in the “Development of Mucosal Immunity and Tissue Integrity Lab” headed by Pedro Hernandez at the Genetics and Developmental Biology Department of Institut Curie in Paris, France.


Our team focuses on identifying and characterizing immune signaling mechanisms regulating intestinal epithelial development and function. The zebrafish offers significant experimental advantages including high fecundity, external development, easy genetic manipulation, small size and transparency. We are combining these advantages with flow cytometry, bulk and single-cell transcriptomic profiling, live microscopy and immune challenges.


We are looking for a highly motivated candidate with a strong interest in interdisciplinary research combining developmental biology and immunobiology. The candidate will manage a research project with focus on understanding the role of cytokine signaling in mucosal tissues such as the intestinal epithelium upon various types of stress.


The candidate will benefit from the top-level scientific environment of Institut Curie, and of state-of-the-art technological platforms. The lab is located in the Curie campus in the heart of Paris providing interdisciplinary expertise and a very friendly and international environment.


Specific requirements

PhD in biological sciences

Experience working in immunology or developmental biology

Highly talented and motivated researcher

Know-how with zebrafish will be an advantage but is not mandatory

Proficiency in bioinformatics and transcriptomics would be a plus

Expertise in molecular and cell biology

Initiative in planning, organizing and designing innovative experiments

Fluency in both spoken and written English


Application

Please send: CV including publications, a statement of interest, and the names and email addresses of 2-3 potential referees to pedrohernandezlab@gmail.com indicating “LASTNAME_Postdoc application” in the subject. For further queries: pedro.hernandez-cerda@curie.fr and visit our website


Department: Biochemistry and Biophysics, Dr. Colin Johnson

Position percentage: 100%

Appointment Basis: 12 Months

Location: Corvallis, Oregon

Anticipated Appointment Begin Date: 1/1/2020

Anticipated Appointment End Date: 2021, possibility of yearly renewal

Posting Date: 9/11/19

Full Consideration Date: 12/1/2019 or until position filled

Contact: colin.johnson@oregonstate.edu

 

Posting Date

 

POSITION DESCRIPTION

Department of Biochemistry and Biophysics, Oregon State University

Job title: Postdoctoral Researcher.

Position title: Postdoctoral scholar (postdoc)


A postdoctoral position is open to work on the molecular and cellular biology of zebrafish neuromasts. The appointee will work with Dr. Colin Johnson (Department

of Biochemistry and Biophysics). The position will be renewed on a yearly basis. The successful candidate will be appointed as a postdoctoral scholar.


Responsibilities:

  • Zebrafish husbandry
  • Characterize zebrafish mutants using confocal microscopy
  • Characterize gene expression in zebrafish and zebrafish mutants using PCR methods
  • Publish the research results in peer-reviewed high-impact scientific journals.
  • OSU at scientific meetings by presenting original research.
  • Take the initiative in finding solutions to scientific problems that arise in day-to-day

research.

  • Collegially engage in collaborative work with peers with the aim to achieve the above

objectives.

 

Minimum Qualifications for a Postdoctoral Scholar include:

  • PhD in Biochemistry, Cell Biology or related field.
  • Demonstrated creativity, independence, high motivation, and good communication skills,

both orally and written.

  • Strong work habits and the ability to work independently as well as with research group.

 

Preferences:

  • Experience in CRISPR methodology
  • Experience in immunofluorescence
  • Experience in western blot analysis
  • Experience in qPCR methodology
  • Experience in zebrafish husbandry
  • Experience in developing publications based on individual research.

The Department of Molecular, Cellular, and Developmental Biology (MCDB) in the College of Literature, Science, and the Arts at the University of Michigan solicits applications for faculty positions at the assistant professor level, but appointment at a more senior level is possible for applicants with suitable experience. The faculty position will be tenured or tenure track with a university year appointment starting September 1, 2020 or January 1, 2021. Successful candidates will be expected to establish a vigorous, extramurally funded research program and to be involved in instruction of both undergraduate and graduate students.

We welcome applications from outstanding biologists in the areas of biochemistry, developmental biology, and neuroscience. Researchers working on either plants, microbial, or animal systems are encouraged to apply. Experimental approaches that are desired include (but are not limited to) genetics, genomics, structural biology, enzymology, physiology, in vivo imaging, and single cell technologies. For further information about MCDB research areas and the goals of this faculty search, please visit lsa.umich.edu/mcdb.

All applications must be submitted on-line. 
https://apps-prod.mcdb.lsa.umich.edu/search19/howtoapply.php

You will be asked to upload the following materials: A cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, a statement of teaching interests and philosophy, and evidence of teaching excellence for those who have teaching experience. Candidates for appointment as an assistant professor should provide names and contact information for at least three references, as instructed in the on-line application form. To ensure full consideration, all materials should be received by October 19, 2019.

Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.

A postdoctoral position is available in the Sam Sidi laboratory, Mount Sinai Medical Center, Manhattan, New York.  Mutational damage to genomic DNA both drives the progression of cancer and remains the main mechanism by which we treat the disease (i.e., via radiotherapy or chemotherapy). p53 signaling, which controls DNA repair vs. apoptosis decisions in damaged cells, has long dominated research into how cells respond to DNA injury. However, p53 signaling is almost universally lost during oncogenesis via mutational inactivation of p53 itself or that of its activators or effectors.  

To both discover new biology in the DNA damage response and define viable therapeutic strategies in cancer, we have conducted large-scale screens for genetic and chemical suppressors of mutant p53 in zebrafish. These efforts have led to the discovery of novel targets for inhibition in p53mutant cancers (e.g., Chk1 and IRAK1 kinases) and to the identification of an alternative apoptotic axis anchored by the PIDDosome complex (PIDD-RAIDD-caspase-2) which retains full functionality in p53-deficient vertebrate cells (see references 1-5 below).   

The successful applicant, an experienced zebrafish researcher with a minimum of basic training in human cell culture biochemistry (e.g., co-IP), will focus on one of several areas currently under investigation:  

1. Genetic dissection of the novel, IRAK1-mediated anti-apoptotic response to radiation therapy (ref. 1). Focus on the molecular events upstream, at the level, and downstream of radiation-induced IRAK1 activation. This research is poised to unveil novel drug targets for overcoming resistance to radiotherapy in the million+ patients who fail to respond due to p53 mutation. Such “radiosensitizing” drugs are essentially unavailable and are direly needed in the clinic.  

2. Biochemical analysis of a novel, p53-independent molecular switch that decides cell survival or death in response to DNA interstrand crosslinks (ICL). We have recently identified a DNA repair molecule with the ability to sense ICL repair failure and trigger apoptosis as a result (Shah and Sidi, unpublished). This is to our knowledge the first described example of a repair/apoptosis switch, with the potential to define a new paradigm in tumor suppression.   

3. Functional analysis of novel regulators of PIDDosome signaling, as recently identified in the lab via RNAi screens and mass spectrometry. Three validated, potentially direct regulators of the complex are available for immediate analysis using combinations of genetics, biochemistry and imaging in zebrafish embryos and cultured human cancer cells (as in refs. 1-4). These projects will both extend our understanding of a novel apoptotic axis in vertebrates, clarify its significance and evolutionary origin, and identify new means to unleash its activity in p53 mutant tumors.     

The applicant will take advantage of the vibrant and cutting-edge environment at Mount Sinai and work with our collaborators in world-class bioinformatics, genomics, microscopy, medicinal chemistry and pharmacology departments. The applicant will also participate in new screening efforts in zebrafish for novel drivers and druggable targets in radioresistant and chemoresistant cancer (as in refs. 1 and 5).  


Please send cover letter and CV (including a minimum of two reference contacts) tosamuel.sidi@mssm.edu  


For more information, please check out our lab websites/media and relevant publications.  

http://labs.icahn.mssm.edu/sidilab/ http://psscra.org/winners/samuel-sidi-phd/

http://www.searlescholars.net/person/575 https://www.youtube.com/watch?v=LnyxoxvtcPo  


1. Liu PH, et al. An IRAK1-PIN1 signaling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol 21:203-213, 2019.  

2. Ando K, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol 216:1795-1810, 2017.  

3. Thompson R, et al. An inhibitor of PIDDosome formation. Mol Cell 58:767-779, 2015.   

4. Ando K, et al. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 47:681-693, 2012.  

5. Sidi S, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2 and caspase-3. Cell 133:864-877, 2008.

Description of the project

The research conducted by our group focuses on the study of neuropeptides in the urotensin II (UII) family. They aim to better understand the functions exerted by these peptides and to characterize more finely the neurons that produce them, especially those located in the spinal cord. For this, we use zebrafish as a study model.

In recent months, we have generated a series of transgenic fish reporter lines labeling the neurons that produce peptides of the UII family. These lines will be used to develop two projects:

1) to determine the origin of the UII-ergic neurons and to characterize the networks in which they take place in the embryo and then the zebrafish larva

2) to isolate these neurons by FACS in order to establish their transcriptome.

The candidate to be recruited will participate in each of these two projects.


Location

National Museum of Natural History, Paris France
Development and Evolution of Neurosecretory Systems (team leader: Hervé Tostivint)

Lab website: https://umr7221.mnhn.fr/?lang=en

 

Candidate profile

The candidates should be highly motivated and able to work both independently and in a collaborative environment, with a strong commitment to achieving assigned objectives. The successful candidate will have a good background in neuroscience and / or developmental biology. An experience in imaging and FACS will be appreciated, as well as a familiarity with the zebrafish model.

 

Appointment

The position is temporary for 1 year but may be extended pending on grant applications.


Net salary 

2360 euros/month

 

Starting date

January 2020


Applications

To apply, please send your CV, motivation letter stating your research interests/plans and the names/contact information of 2/3 referees to htostivi@mnhn.fr

The Section of Ecology, Behavior and Evolution in the Division of Biological Sciences (www.biology.ucsd.edu) invites applications for a faculty position at the tenure-track Assistant Professor or tenured Associate or Full Professor level. Competitive candidates will investigate evolutionary questions through mechanistic studies of the developmental or physiological processes that produce phenotypic variation. Research topics could include, but are not limited to: evolutionary innovation; developmental constraints; phenotypic plasticity and genetic accommodation; and the evolution of genotype-phenotype maps. We welcome applicants incorporating laboratory, field, and/or theoretical components in their research.

The Division of Biological Sciences at UCSD is a vibrant center of scientific discovery, innovation, and collaboration. Our large research base spans many areas of biology and has one of the most celebrated graduate programs in the country. We are committed to academic excellence and diversity within the faculty, staff, and student body.

All candidates must have earned a Ph.D. or equivalent degree, and be committed to teaching at the undergraduate and graduate levels. Associate and Full Professor candidates must possess strong leadership skills. In addition to excellence and creativity in research and scholarship, successful candidates must also demonstrate a commitment to equity and inclusion in higher education. We are especially interested in candidates who have created or contributed to programs that aim to increase access and success of underrepresented students and/or faculty in the sciences, and/or have detailed plans to accomplish such goals.

Salary is commensurate with qualifications and based on University of California pay scales.

Initial review of applications will commence on October 28, 2019 and will continue until position is filled.

Interested applicants must submit a cover letter, curriculum vitae, statement of research, statement of teaching, a statement describing their past experience and leadership in fostering equity and diversity and/or their potential to make future contributions, and 3-5 publications. For information on preparing diversity statements and divisional initiatives to promote diversity, see: http://facultyequity.ucsd.edu/Faculty-Applicant-C2D-Info.asp and http://biology.ucsd.edu/diversity/index.html. Applicants at the Assistant Professor level need to submit 3-5 references, and applicants at the Associate or Full Professor level need to provide contact information for 3-5 references.

Applications must be submitted through the University of California San Diego’s Academic Personnel RECRUIT System:

Assistant Rank: https://apol-recruit.ucsd.edu/JPF02235

Associate or Full Rank: https://apol-recruit.ucsd.edu/JPF02236

Further details about the required application material can be found at: http://biology.ucsd.edu/jobs/apply-lrf-lsoe.html

UCSD is an Affirmative Action/Equal Opportunity Employer with a strong institutional commitment to excellence through diversity (http://diversity.ucsd.edu/). All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, sexual orientation, national origin, disability, age or protected veteran status.