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The University of Massachusetts Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research. The Medical School attracts more than $174 million in research funding annually, 80 percent of which comes from federal funding sources. UMMS is the academic partner of UMass Memorial Health Care, the largest health care provider in Central Massachusetts.

A postdoctoral position is available for a highly motivated candidate to develop artificial nucleases for targeted gene disruption in mosquitoes and zebrafish. These studies will focus on developing and implementing new nuclease technologies to understand gene function in disease/pathogen related pathways that will lay a foundation for the development of new targeted therapeutics. The laboratory uses zebrafish as a model organism for two major projects: Developing tools for gene inactivation and modification in vertebrate systems and creating disease models of obesity, diabetes and atherosclerosis.

Candidates should possess a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be prepared to present research results at national meetings. Prior experience with zebrafish and obesity/diabetes research is advantageous, but not required.

Major Responsibilities:
1. Generation and testing of artificial nucleases for targeted gene knockouts
2. Responsible for the maintenance of mutant and transgenic zebrafish lines
3. Genotyping/phenotyping mutant zebrafish

Experience Desired (not required):
1. Experience with zebrafish husbandry
2. Experience with obesity and diabetes animal models
3. Basic molecular biology techniques (PCR, Restriction Enzyme mediated cloning, Gel electrophoresis, Qiagen DNA miniprep)
4. Familiarity with protein-DNA recognition in zinc fingers or related systems

To Apply:
For consideration, applicants should send a letter describing their current research activities and their interest in this position, CV (including publications) and contact information for three references (including PhD advisor) to: (Please indicate Post Doc Requisition #21787 in the Subject Line.)

or via postal mail to:
Scot Wolfe
University of Massachusetts Medical School
Program in Gene Function & Expression
364 Plantation St., LRB Room 619
Worcester, MA 01605
Further details about the Wolfe laboratory can be found at:

As an equal opportunity and affirmative action employer, UMMS recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds.

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