A postdoctoral opening is available immediately in the Yin laboratory at the Cincinnati Children’s Hospital Medical Center, Division of Gastroenterology, Hepatology and Nutrition. Our group collaborates with physicians in the Pediatric Liver Center and geneticists in the Division of Human Genetics to conduct translational research on childhood inherited cholestatic liver diseases. We use zebrafish and mouse models to study disease pathogenesis, discover causative variants, and develop novel therapeutic strategies. Projects utilize multidisciplinary approaches: genetics (next generation sequencing, transgenesis, and application of CRISPR/Cas9 genome editing to generate mutants), confocal imaging, chemical screen, bioinformatics, and liver pathophysiology. We also have the unique opportunity to validate experimental findings in patient liver samples.
Details about project areas can be found at:
Our recent publication:
Ellis JL, Bove KE, Schuetz EG, Leino D, Valencia CA, Schuetz JD, Miethke A, Yin C. Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology. 2018 Apr;67(4):1531-1545. doi: 10.1002/hep.29632. PubMed PMID: 29091294. (https://www.ncbi.nlm.nih.gov/pubmed/29091294)
We seek a highly motivated scientist who is independent, focused, productive, and possesses exceptional skills in cellular/molecular biology and an enthusiasm for learning and developing new techniques. Candidate must hold a recent doctorate in Cell/Developmental Biology, Genetics, or related field, and proficient in spoken and written English. Experiences with zebrafish and rodent models and background in hepatology are desirable, not essential.
Interested applicants should submit a cover letter detailing research experience and future interests, a Curriculum Vitae, and arrange for three letters of recommendation to be sent to:
Chunyue Yin, PhD
Cincinnati Children's Hospital Medical Center is an Affirmative Action/Equal Opportunity Institution. Women and Minorities are encouraged to apply.