A postdoctoral fellowship/senior research associate position is currently available in the Mchaourab lab at Vanderbilt University in Nashville, TN. The project entails the use of zebrafish as an experimental model to understand the proteostasis network in the lens and heart. We apply advanced genetic approaches, including transgenesis and genome editing (such as CRISPR/Cas9), and microscopic imaging techniques to decipher the functional roles of small heat shock proteins for the maintenance of transparency during lens aging as well as stress resistance of the heart. Our recent discovery revealed a direct coupling between proteostasis and cortisol stress signaling (Mishra et al., 2018, JBC; Wu et al., 2016, JBC) and future directions will seek to investigate the mechanistic bases of this coupling.
We are a highly interdisciplinary group with research interests ranging from chaperones to multidrug transporters. The Mchaourab laboratory is located in the Department of Molecular Physiology and Biophysics with readily access to many state-of-the-art cores in fluorescence microscopy, mass spectrometry and various biophysical instrumentation. The position will provide opportunities for applying mechanistic biochemistry in vitro to complement the in vivo genetic analysis as well as learning advanced biophysical techniques.
Candidates should have a Ph.D. in Biochemistry, Cell Biology, Genetics, or related fields. The ideal candidate will have expertise in microscopy, image analysis, and modern molecular biology techniques, with previous experience in zebrafish rearing and husbandry.
If interested, please send your CV to: Hassane S. Mchaourab, Ph. D. (firstname.lastname@example.org)