Postdoctoral positions are available in the Goldman Lab at the University of Michigan, Ann Arbor. Our research employs zebrafish to study central nervous system regeneration. We use the retina as a model system because it is a relatively simple part of the CNS and experimentally accessible. Our studies indicate that Muller glial cells in the retina respond to retinal injury by adopting stem cell characteristics that allow them to generate multipotent progenitors that regenerate ablated retinal neurons. Our current research is focused on understanding the molecular mechanisms underlying Muller glial cell reprogramming, investigating Muller glial cell heterogeneity, and developing transgenic zebrafish as a platform in chemical screens to identify those that can stimulate retina regeneration. Our studies rely on molecular and cell biology and take advantage of RNAseq, ATACseq, CRISPR/Cas9 gene editing, and transgenic approaches. Factors stimulating retina regeneration in fish will be tested in mice.
We seek a recent PhD that is highly motivated, bright and creative to join our group. Candidates must have demonstrated expertise (publications) in molecular and cellular biology and preference will be given to those already familiar with the retina and/or zebrafish.
Qualified candidates should send by email their CV, statement of research interests and description of past research accomplishments, along with contact information for at least 2 referees to:
Dan Goldman, PhD
Univ of Michigan, Medical Schl, 5045 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109