NYC-based start-up biotech company is looking for a research scientist with minimum 4+ years of post-doctoral experience in neurobehavioral studies in zebrafish for high-impact R&D program. Knowledge in zebrafish experimental design, execution, and analyses required. This exciting opportunity will provide competitive compensation and significant pathways for career development and growth. Please send cover letter and resume to anodynebio@gmail.com.
We are seeking a Research Assistant - This position is in the Center for Childhood Cancer and Blood Diseases in Dr. Genevieve Kendall’s lab. We are seeking a motivated research assistant to join our lab group. Our team is focused on developing basic and translational models of pediatric sarcomas, which are devastating and aggressive solid tumors with limited therapeutic options. Specifically, we study rhabdomyosarcoma, which is thought to arise from a misregulation of skeletal muscle developmental pathways.
We use cell culture and transgenic zebrafish systems to understand the underlying biology of the disease and then apply that knowledge to identify therapeutic targets. Identified targets and therapeutic strategies are then confirmed via our model systems and through collaborations with the extensive expertise present in the Center for Childhood Cancer and Blood Diseases, Division of Hematology/Oncology and BMT, and in the Institute for Genomic Medicine.
With guidance from Dr. Kendall, you will be responsible for independently progressing your own project, and assisting other lab personnel in a complementary manner that addresses our shared interests and aligns with your career goals. Your responsibilities will include maintaining transgenic zebrafish lines, performing experiments, and analyzing and presenting your results and conclusions. You will also be responsible for lab management and safety, ordering, and assisting Dr. Kendall with protocol preparation and submission.
A background in molecular biology is preferred. Zebrafish research experience is not required, but you must be comfortable with and excited about learning this model. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that will fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment.
Responsibilities
What Will You Be Doing?
- Designing and conducting laboratory-based experiments with transgenic zebrafish and cell culture based systems (utilizing skills/techniques such as microinjection, cloning, imaging, microdissection, flow cytometry, qPCR, immunofluorescence, immunohistochemistry, in situ hybridization, Western blots, RNAseq/ATACseq/single cell sequencing, generating new transgenic zebrafish lines, etc.)
- Collecting experimental data and maintaining a lab notebook
- Critically evaluating and interpreting data and determining next steps
- Mentoring and training staff and graduate students
- Generating figures in Adobe Illustrator
- Writing and publishing scientific material, including manuscripts
- Presenting research at regional, national, and international conferences
- Contributing to grant submissions for external funding
- Collaborating with other researchers at NCH/OSU, nationally, and internationally
- Performing miscellaneous related duties to help the team
Qualifications
What Are We Looking For?
To fulfill this role successfully, you must possess these qualifications and experience:
- Bachelor’s Degree in a relevant field of science from an accredited college
- Six months to two years of relevant laboratory experience preferred
- Strong organizational skills
- Self-motivated
- Technical skills in a sub-set of the areas of research described above and a desire to quickly learn new skills
- Ability to work independently on laboratory projects
- Proficiency in scientific writing
- Software expertise to prepare presentations, and to make figures and tables
- Excellent communication skills
- Ability to train and mentor laboratory staff, graduate students, and post-docs
Your Benefits, Your Wellness:
As an employer, Nationwide Children’s recognizes the importance of the benefits we offer. We also recognize the importance of balancing your work and personal needs. Our benefits and Employee Wellness package is designed to:
- Empower you to be a conscientious health care consumer through educational and wellness activities
- Establish a work environment that promotes health and well-being
- Support your financial protection and security in retirement
Most of our positions are benefits’ eligible from day 1.
Why Nationwide Children's Hospital?
The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose.
Here, Everyone Matters. We’re 12,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere.
Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere.
Nationwide Children’s Hospital. A Place to Be Proud.
We are seeking a Research Associate - This position is in the Center for Childhood Cancer and Blood Diseases in Dr. Genevieve Kendall’s lab. We are seeking a motivated research associate to join our lab group. Our team is focused on developing basic and translational models of pediatric sarcomas, which are devastating and aggressive solid tumors with limited therapeutic options. Specifically, we study rhabdomyosarcoma, which is thought to arise from a misregulation of skeletal muscle developmental pathways.
We use cell culture and transgenic zebrafish systems to understand the underlying biology of the disease and then apply that knowledge to identify therapeutic targets. Identified targets and therapeutic strategies are then confirmed via our model systems and through collaborations with the extensive expertise present in the Center for Childhood Cancer and Blood Diseases, Division of Hematology/Oncology and BMT, and in the Institute for Genomic Medicine.
With guidance from Dr. Kendall, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include performing experiments, determining the next steps, developing and implementing new and existing protocols, analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts.
A background in molecular biology is required. Experience with zebrafish modeling of disease or skeletal muscle development would be beneficial. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that will fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment.
Responsibilities
What Will You Be Doing?
- Designing and conducting laboratory-based experiments with transgenic zebrafish and cell culture based systems (utilizing skills/techniques such as microinjection, cloning, imaging, microdissection, flow cytometry, qPCR, immunofluorescence, immunohistochemistry, in situ hybridization, Western blots, RNAseq/ATACseq/single cell sequencing, generating new transgenic zebrafish lines, etc.)
- Collecting experimental data and maintaining a lab notebook
- Critically evaluating and interpreting data and determining next steps
- Mentoring and training staff and graduate students
- Generating figures in Adobe Illustrator
- Writing and publishing scientific material, including manuscripts
- Presenting research at regional, national, and international conferences
- Contributing to grant submissions for external funding
- Collaborating with other researchers at NCH/OSU, nationally, and internationally
- Performing miscellaneous related duties to help the team
Qualifications
What Are We Looking For?
To fulfill this role successfully, you must possess these qualifications and experience:
- Master's degree or Ph.D.
- Strong organizational skills
- Self-motivated
- Technical skills in a sub-set of the areas of research described above and a desire to quickly learn new skills
- Ability to work independently on laboratory projects
- Proficiency in scientific writing
- Software expertise to prepare presentations, and to make figures and tables
- Excellent communication skills
- Ability to train and mentor laboratory staff, graduate students, and post-docs
Your Benefits, Your Wellness:
As an employer, Nationwide Children’s recognizes the importance of the benefits we offer. We also recognize the importance of balancing your work and personal needs. Our benefits and Employee Wellness package is designed to:
- Empower you to be a conscientious health care consumer through educational and wellness activities
- Establish a work environment that promotes health and well-being
- Support your financial protection and security in retirement
Most of our positions are benefits’ eligible from day 1.
Why Nationwide Children's Hospital?
The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose.
Here, Everyone Matters. We’re 12,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere.
Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere.
Nationwide Children’s Hospital. A Place to Be Proud.
We are seeking a Postdoctoral Scholar - This position is in the Center for Childhood Cancer and Blood Diseases in Dr. Genevieve Kendall’s lab. We are seeking a motivated postdoctoral scholar to join our lab group. Our team is focused on developing basic and translational models of pediatric sarcomas, which are devastating and aggressive solid tumors with limited therapeutic options.
Specifically, we study rhabdomyosarcoma, which is thought to arise from a misregulation of skeletal muscle developmental pathways. We use cell culture and transgenic zebrafish systems to understand the underlying biology of the disease and then apply that knowledge to identify therapeutic targets. Identified targets and therapeutic strategies are then confirmed via our model systems and through collaborations with the extensive expertise present in the Center for Childhood Cancer and Blood Diseases, Division of Hematology/Oncology and BMT, and in the Institute for Genomic Medicine.
With guidance from Dr. Kendall, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include performing experiments, determining the next steps, developing and implementing new and existing protocols, analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts.
A background in zebrafish modeling of disease, skeletal muscle development, RNAseq, ATACseq and single cell sequencing is not required, but would be beneficial. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that will fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment.
Responsibilities
What Will You Be Doing?
- Designing and conducting laboratory-based experiments with transgenic zebrafish and cell culture based systems (utilizing skills/techniques such as microinjection, cloning, imaging, microdissection, flow cytometry, qPCR, immunofluorescence, immunohistochemistry, in situ hybridization, Western blots, RNAseq/ATACseq/single cell sequencing, generating new transgenic zebrafish lines, etc.)
- Collecting experimental data and maintaining an updated lab notebook
- Critically evaluating and interpreting data and determining next steps
- Mentoring and training staff and graduate students
- Generating figures in Adobe Illustrator
- Writing and publishing scientific material, including manuscripts
- Presenting research at regional, national, and international conferences
- Contributing to grant submissions for external funding
- Collaborating with other researchers at NCH/OSU, nationally, and internationally
- Performing miscellaneous related duties to help the team
Qualifications
What Are We Looking For?
To fulfill this role successfully, you must possess these qualifications and experience:
- MD, Ph.D., Pharm.D., or equivalent degree.
- Desire to pursue a career in biomedical research
- Technical skills in a sub-set of the areas of research described above and a desire to quickly learn new skills
- Ability to work independently on laboratory projects
- Proficiency in scientific writing
- Excellent communication skills
- Ability to train and mentor laboratory staff and graduate students
Your Benefits, Your Wellness:
As an employer, Nationwide Children’s recognizes the importance of the benefits we offer. We also recognize the importance of balancing your work and personal needs. Our benefits and Employee Wellness package is designed to:
- Empower you to be a conscientious health care consumer through educational and wellness activities
- Establish a work environment that promotes health and well-being
- Support your financial protection and security in retirement
Most of our positions are benefits’ eligible from day 1.
Why Nationwide Children's Hospital?
The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose.
Here, Everyone Matters. We’re 12,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere.
Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere.
Nationwide Children’s Hospital. A Place to Be Proud.
https://www.radboudumc.nl/en/vacancies/75481-phd-candidate-on-zebrafish-model-for-paragangliomas
PhD candidate on zebrafish model for paragangliomas
- Temporary
- 36 hours a week
- 3 years
- Date of publication: 19 November 2019
- Deadline: 17 December 2019
- Scale 10: min € 2826 - max € 4481 gross per month at full employment (excl. vacation bonus and end of year payments)apply to job
Job description
Paragangliomas are tumors that originate from chromaffin cells in the adrenal medulla (also called paraganglioma) or sympathetic ganglia. Chromaffin cells are neuro-endocrine cells that can procedurecatecholamines such as adrenaline, noradrenaline and dopamine. Every year, between 100 and 150 new paraganglioma cases are reported in the Netherlands. Currently, there is no effective treatment for patients with metastatic or inoperable paraganglioma. There is an urgent clinical need for development of therapeutics against this disease, which requires a better understanding of the etiology and pathophysiology of paraganglioma. About 40 percent of the paraganglioma can be explained by agermline mutation in a variety of genes. So far, 18 paraganglioma-related genes have been identified. A mutation in one of these paraganglioma-related genes, the succinate dehydrogenase B (SDHB), is the strongest indicator of malignancy. The SDHB protein is part of a four subunit (A-D) protein complex, the succinate dehydrogenase (SDH) complex. The SDH complex converts succinate to fumarate, one of the steps of the TCA cycle. When this complex is dysfunctional there is a build-up of succinate in the cell. Succinate stabilizes hypoxia-inducible transcription factors (HIFs). HIF-targets are subsequently transcribed and in turn boost proliferation and angiogenesis, two essential processes of tumor formation. To further unravel the pathogenesis and etiology of this disease and to develop and test new therapeutic strategies we use an existing zebrafish as animal model.
Tasks and responsibilities- The PhD candidate will design and perform scientific research in health and disease.
- Characterization of inter-renal tumor formation in systemic and tissue-specific sdhb mutantzebrafish.
- Identification of potentially therapeutic targets and drugs.
- Generates and critically analyses the data in order to contribute to scientific publications and presents findings at scientific meetings.
- Works in a team with other students and scientists to discuss, plans and performs research in a stimulating environment.
- Works in a highly international research group with fellows from many countries.
- Supervise MSc and/or BSc students.
- Write and defend a PhD thesis within four years of starting the project.
- Candidate will take part in the graduate school of Radboudumc.
Profile
- MSc degree in Biomedical Sciences or Molecular Life Sciences or a related field.
- Experience with molecular and cell biology is considered a strong plus.
- Article 9 of the Dutch Law on Animal Experimentation is considered a strong plus.
- Experience with in vitro and in vivo modeling using zebrafish and/or cell lines is considered a plus.
- Experience with bio-informatics is considered a plus.
- Structured working style.
- A strong motivation, flexibility, and willingness to learn.
- Critical scientific attitude and be able to work both independently as well as in a group.
- Excellent communication skills; oral and in writing.
Organization
The Laboratory of Experimental Medicine, part of the Department Internal Medicine, is heading by Prof. Mihai Netea and Prof. Leo Joosten and is a large research laboratory, in which approximately 40 PhD students work together with postdoc’s and technicians.
Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.
Read more about what it means to work at Radboudumc and how you can do your part.Employment conditions
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.Comments and contact information
Applicants should include a letter of intent outlining special interest in the position, related qualifications, experience and career goals, a curriculum vitae, including a list of grades of your BSc MSc components and names and addresses of professional references in the application.
All additional information about the vacancy can be obtained from Dr. Margo Dona, post-doc Internal Medicine and Henri Timmers, MD, PhD, associate professor Internal Medicine. Use the Apply button to submit your application.
Please apply before December 17.
The team Onset of Immunity/Immune Cell activation of the Laboratory of Pathogen-Host Interaction in Montpellier, is looking for a talented postdoctoral fellow to work on the dynamics of macrophage polarization in response to a wound. The optical transparency of the zebrafish larva provides the ability to visualise immune cells in their activated state using transgenic approaches to understand immune response in the host. The aim of the project is to use the many advantages of zebrafish to dissect molecular mechanisms involved in macrophage polarization switch during wound healing.
The postdoc position is funded for two years through a 1-year contract to be renewed.
The young scientist will be involved in the design and implementation of the experiments. This will include manipulating the immune response of the zebrafish embryo and larvae through mutants or phenocopies of, triggering the immune cells through different stimuli (wounds and infections), live imaging in the zebrafish larva, preparing samples for single cell RNA-seq, developing new transgenic reporter or mutant lines and data analysis.
The candidate should hold a Ph.D. in biological sciences with an expertise in the zebrafish model and/or in the field of immunology. Knowledge in the CrispR/Cas9 system would be appreciated or skills in computational analysis.
The candidate should harbor excellent skills in the organization of his/her work and in interacting with a team. He/She should be able to speak and write in English language.
Interested applicants should send their CV, a letter of motivation, and the names and e-mails of 2 references to Mai Nguyen-Chi (mai-eva.nguyen-chi@umontpellier.fr) and Georges Lutfalla (georges.lutfalla@umontpellier.fr) or should apply via the CNRS portal (https://emploi.cnrs.fr/Offres.aspx).
Selected publications of the hosting team:
Phan QT, Sipka T, Gonzalez C, Levraud JP, Lutfalla G, and Nguyen-Chi M (2018) Neutrophils use superoxide to control bacterial infection at a distance. Plos Pathog, 14(7): e1007157.
Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., and Djouad, F. (2017). TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death Dis. 8, e2979.
Bernut, A., Nguyen-Chi, M., Halloum, I., Herrmann, J.-L., Lutfalla, G., and Kremer, L. (2016). Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. PLOS Pathog. 12, e1005986.
Nguyen-Chi M., Laplace-Builhe B., Travnickova J., Luz-Crawford P., Tejedor G., Phan Q. T., Duroux-Richard I., Levraud J. P., Kissa K., Lutfalla G., Jorgensen C., Djouad F. (2015) Identification of polarized macrophage subsets in zebrafish. eLife 2015;4 :e07288.
Work environment
Montpellier is one of the best place in France for life science research and the best place, in France, to study host pathogen interactions in the Zebrafish model. The Laboratory of Pathogen Host Interaction (LPHI) is a very well funded department with grants from the H2020 excellence pillar (ERC and MSCA-ETN) and from many other national and international funding bodies. With more than 15 nationalities represented, the working language is English.
Research at Laboratory of Pathogen Host Interaction (LPHI) focuses on the study of host-pathogen interactions, with emphasis on infections by parasites (Plasmodium, Toxoplasma), bacteria (Mycobacterium, Staphylococcus, Salmonella) and viruses (virus particle biogenesis and antiviral defenses). Three main axes are developed: parasitology, microbiology and immunology. While some groups are using mammalian systems, the zebrafish is widely used at LPHI.
The team in which the candidate will be recruited uses the zebrafish as a model system to studying innate host defense mechanisms involved in bacterial infections and innate immune responses during wound healing. The optical transparency of the zebrafish embryo combined with innovative technics in cell labelling provides an outstanding opportunity to visualize innate immune cells including neutrophils and macrophages during an infection or a tissue injury. In this context we study how the phagocytes respond to environmental signals and change their fate. This project, funded by the French National Research Agency (ANR), will be more particularly focused on the dynamics of macrophage polarization during wound healing.
The group has acquired an international renown in the generation of transgenic lines that are instrumental for immune studies and that have been asked by laboratories all over the world.
The candidate will be supervised by Mai Nguyen-Chi in the team of Georges Lutfalla « Onset of immunity and inflammation ». He/She will have access to the zebrafish facility of the university of Montpellier and all the innovative techniques in microscopy and genomic analysis thanks to the platforms of Montpellier, MRI and MGX.
Assistant/Associate Professor - Neurobiology of Brain Organoids
The Department of Biology at Syracuse University is seeking applicants in the field of brain organoid biology. This position is part of a groundbreaking cluster hiring initiative at Syracuse University, that will include13 new hires over the next 3 years focused on bio-inspired research across the Colleges of Arts & Sciences and Engineering & Computer Science. As an integral part of this investment, Syracuse University is actively recruiting multiple candidates for tenured/tenure-track faculty positions for a cohesive research cluster in the focus area of multicellular mechanics of development and disease. Faculty hired into these positions will build on our existing strengths in the focus area and will affiliate with a newly formed multidisciplinary BioInspired Syracuse Institute for Material and Living Systems, the goal of which is to enhance collaboration and promote world-class interdisciplinary research to quantitatively understand complex biological systems. Further information on the campus-wide hiring initiative can be found at bioinspired.syr.edu.
This specific search seeks a scholar examining cutting edge questions on the mechanics of cell-cell interactions (including neurons and glia), stem cell development, and brain formation in the broad field of brain organoid biology with expertise in understanding development and/or disease. Candidates must have a Ph.D with backgrounds in Neuroscience, Biomedical or Tissue Engineering, and/or Molecular, Cellular, and Developmental Biology and a record of productive research. The successful applicant will be expected to establish a strong, externally funded research program and participate in graduate and undergraduate teaching and mentoring.
The Biology Department at Syracuse University (http://biology.syr.edu/) currently has 33 full-time faculty with broad research strengths in neurobiology, cell and developmental biology, evolutionary biology, and plant and ecosystem ecology. The selected candidate will complement existing strengths in the Biology Department which include developmental neurobiology, astrocyte biology, neuropharmacology and toxicology, cell and molecular neurobiology, neurological disease modeling and behavioral neuroscience.
Applicants should submit a cover letter, curriculum vitae, statements of research and teaching interests, and arrange for three references to send letters to , preferably by December 15th, 2019 to http://www.sujobopps.com/postings/82139. The search will remain open until the position is filled.
Syracuse University is interested in candidates who have the communication skills and cross-cultural abilities to maximize their effectiveness with diverse groups of colleagues, students and community members. Syracuse University is an equal opportunity/affirmative action employer with a strong commitment to equality of opportunity and a diverse work force.
The Centre for Developmental Neurobiology invites applications for junior tenure-track group leader positions in developmental neuroscience.
We are looking to recruit outstanding early career investigators who will make significant contributions to developmental neuroscience defined broadly, including human brain development, the emergence of brain structure and function as well as neural plasticity and neurodevelopmental disorders. We are seeking innovative scientists with promising potential for developing an internationally recognised research programme. The originality of the candidate's work will take precedence over the sub-area of specialisation. Applicants should be seeking a stimulating interdisciplinary environment in which to pursue research.
We are particularly interested in early career applicants who meet the eligibility criteria for career development fellowships (such as those offered by the Wellcome Trust and the Research Councils). Successful candidates will establish their own independent research group in the Centre supported by a fellowship and will then progress to a tenured post subject to a satisfactory progress review.
Successful candidates will have their primary appointment at the Centre for Developmental Neurobiology within the Institute of Psychiatry, Psychology and Neuroscience at King’s College London. Depending on their research programme, candidates may also have a secondary appointment with the MRC Centre for Neurodevelopmental Disorders.
These posts are an exciting opportunity for early career academics to establish their own independent research group within King’s College London’s vibrant neuroscience research community. Successful candidates will be given office and laboratory space, access to state-of-the art core facilities, a PhD studentship and additional opportunities to recruit students from various PhD programmes. Mentorship from a senior faculty member and career development opportunities will also be provided.
To apply, please submit:
- A one-page summary of research achievements;
- A one-page outline of your proposed research;
- Your academic CV; and
- The names of three potential reviewers
to Dr Tamara al Janabi, Research Strategy Manager, via e-mail: tamara.al_janabi@kcl.ac.uk.
Please write “Application for tenure-track group leader” in the subject of your e-mail.
For an informal discussion about the position, please contact Professor Oscar Marín via email:
oscar.marin@kcl.ac.uk. Please write “CDN tenure-track group leader” in the subject of your e-mail.
Closing date for receipt of applications is 23:59 GMT on 22nd November 2019.
The Centre for Developmental Neurobiology occupies the entire fourth floor of New Hunt's House, a multipurpose research and teaching building on the Guy's Campus of King's College London next to London Bridge in central London. The Centre has a team of over 150 researchers and is part of the Institute of Psychiatry, Psychology and Neuroscience, King’s College London. Our work focuses on understanding the mechanisms that control brain development and how deviations from the normal plan lead to disease. We carry out highly collaborative and multi-disciplinary studies using an array of model organisms (http://www.devneuro.org).
King’s College London values diversity and is committed to equality of opportunity. The Institute of Psychiatry, Psychology and Neuroscience has a dedicated Diversity and Inclusion team. You can read more about their work here: https://www.kcl.ac.uk/ioppn/diversity-inclusion/our-work/our-work.
QMUL20339
Department: School of Biological & Chemical Sciences
Salary: is £34,220 - £38,084 (Grade 4)
Reference: QMUL20339
Location: Mile End
Date posted: 06-Nov-2019
Closing date: 06-Dec-2019
Overview:
A Research Assistant position is available at Queen Mary University of London (QMUL) as part of a joint project between QMUL and the University of Cambridge funded by the National Institute of Health, USA. The project ‘Exploiting zebrafish genetics to identify genes affecting addiction-related phenotypes’ seeks to use studies in zebrafish to understand the genetic factors influencing vulnerability to nicotine addiction.
This particular research position will focus on the screening and subsequent developmental analysis of mutant lines generated by the Sanger Institute. You will work together with 2 PhD students and a research technician within the School of Biological and Chemical Sciences at QMUL under the direct supervision of Dr Caroline Brennan, but will also closely collaborate with the research group of Dr Elisabeth Busch-Nentwich at the University of Cambridge.
The candidate will work with other members of the group to screen mutant lines for behavioural phenotypes. Phenotypes of interest include conditioned place preference and impulse control. Mutant families of interest will be subject to further developmental and behavioural characterisation. The ideal candidate for this position should have a PhD (or equivalent experience/qualification) in Neuroscience, Genetics, Biology or related subject. Experience of behavioural analysis and cell biological characterisation of behavioural phenotypes is essential. Experience in the handling and maintenance of zebrafish and behavioural analysis in fish is desired. RNA extraction and genetic analysis is desirable. Strong organisational skills and team working are essential.
This is a full-time, fixed term post available for a period of 40 months. The start date is 1/12/2019 or as soon as possible thereafter. The starting salary is £34,220 - £38,084 per annum and is inclusive of London allowance. Benefits include 30 days annual leave, pension scheme and an interest–free season ticket loan.
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries for further information are welcomed and may be made to Dr. Caroline Brennan, email: c.h.brennan@qmul.ac.uk or Tel +44 (0)20 7882 6357
For further information about the School, please see http://www.sbcs.qmul.ac.uk.
To apply, please click the link below.
Application enquiries should be directed to recruitment@qmul.ac.uk
The closing date for applications is 6 December 2019. Interviews will be held shortly thereafter.
Valuing Diversity & Committed to Equality
The Fish Evo Devo Geno Lab at Michigan State University (PI: Ingo Braasch) is recruiting highly motivated PhD students interested in working on the genomic basis of vertebrate evolution and development to start in Summer/Fall 2020.
The Braasch Lab focuses on genomic and developmental changes that contribute to major transitions during the course of vertebrate evolution and studies evolutionary novelties at the levels of genome structure, gene family evolution, and gene regulation. We combine sequencing and comparative analyses of fish genomes with analyses of molecular evolution and functional genetic and developmental approaches (CRISPR genome editing, transgenics, gene expression analyses, epigenomic profiling) in a variety of model species (zebrafish, spotted gar, medaka, and others).
Graduate projects fall within the following broader research areas of the group:
- Evolutionary genomic analyses of zebrafish and other biomedical fish models
Combining genomic sequence comparisons, gene expression analyses and epigenomic profiling, we aim to improve connectivity of teleost biomedical fish models such as zebrafish, medaka, killifishes, etc. to human biology and disease. We use ‘bridge species’ such as spotted gar to translate biomedical research from zebrafish to human and vice versa. This work is support by the NIH.
- Genomic and morphological evolution of fishes
How do morphological differences among fish and other vertebrate lineages arise from diversification of gene repertoires? What is the role of gen(om)e duplications and gene losses in generating phenotypic diversity? How do changes in gene regulation contribute to evolutionary novelties and key innovations? We study a number of gene families that are of particular importance for the evolution of the vertebrate body plan, e. g. genes involved in development of the vertebrate-specific neural crest cells.
- Conquest of land and ‘fish-out-of-water’
We are studying genomic changes and their functional consequences leading to the evolution of tetrapods from fishes and other ‘fish-out-of-water’ scenarios, including the evolutionary loss of genes at the water-to-land transition and the gene regulatory basis of hatching.
For additional information on our research, see also Braasch et al. 2016, Nature Genetics (doi:10.1038/ng.3526) and Braasch et al. 2015, JEZB (doi:10.1002/jez.b.22589).
The Fish Evo Devo Geno Lab is part of the Department of Integrative Biology (IBIO), the Ecology, Evolutionary, and Behavior Program (EEBB), the Genetics and Genome Sciences Graduate Program at Michigan State University, and member of the NSF BEACON Center for the Study of Evolution in Action.
MSU IBIO has a strong research commitment to vertebrate biology with a highly collaborative community of groups working on vertebrate and fish evolution, genomics, development, population genetics, neuroscience, behavior, ecology, and conservation, allowing for vibrant exchange among fields, methods and model systems.
Qualifications:
Applicants should hold a bachelor’s degree in biology, genetics, genomics, molecular biology, bioinformatics, developmental biology, zoology or related fields. Suitable candidates should be enthusiastic about working in an interdisciplinary manner and have a passion for fish/vertebrate biology and evolution. Previous research experience in a relevant area is desired, but not required.
Admission:
Students will be admitted through the MSU IBIO Graduate Program (https://integrativebiology.natsci.msu.edu/graduate-program/) and the MSU Ecology, Evolutionary Biology, and Behavior Program (https://eebb.natsci.msu.edu/). Another possible route of admission is through the MSU Genetics and Genome Sciences Graduate Program within the MSU BioMolecular Science Gateway (https://biomolecular.natsci.msu.edu/applicants/how-to-apply/).
Application deadline for the MSU IBIO and Genetics Graduate Programs are December 1, 2019.
Funding:
Financial support is provided through research and teaching assistantships and the PI’s external funding. Competitive applicants will be eligible for university fellowships and supported in applying for graduate fellowships from NSF, NIH, and other agencies.
Interested candidates should email Ingo Braasch (braasch@msu.edu) in advance of the application deadlines on December 1.
Please include the following in your email:
- Brief description of your research interests and how they align with pursuing a PhD in vertebrate Evo-Devo and genomics
- Curriculum Vitae
- Names and email contacts of 2-3 references
We are looking forward to your application!
Ingo Braasch
Assistant Professor
Department of Integrative Biology
College of Natural Science
Michigan State University
braasch@msu.edu; phone: +1 (517) 432-3484
Twitter: @fishevodevogeno
Rutgers, The State University of New Jersey is seeking a Postdoctoral Fellow for the Department of Biochemistry & Molecular Biology at the Rutgers Robert Wood Johnson Medical School.
The laboratory of Paul R. Copeland seeks to determine the molecular basis for the dietary requirement for the essential trace element selenium, which is a master regulator of oxidative stress that is required for cancer prevention, immune cell function and male fertility. Selenium is incorporated into 25 proteins in humans as the “21st” amino acid, selenocysteine (Sec). The incorporation of this amino acid is unique because it requires a modification of the genetic code since the Sec tRNA recognizes the UGA stop codon. Our lab studies all aspects of Sec incorporation both at the molecular and cellular levels. Currently we are establishing transgenic zebrafish lines to address key questions in the context of developmental and organismal biology. Thus, we are bringing a broad range of techniques spanning in vitro translation to organismal biology to determine how Sec is incorporated and how Sec-containing proteins function.
This grant funded postdoctoral position will be responsible for executing all aspects of our use of zebrafish as an experimental model to investigate the mechanism of Sec incorporation and selenoprotein function.
Further Details and application information can be found at this link
Full-Time Postdoctoral Fellow in the NechiporukOregon Health & Science University, School of Medicine, Department of Cell, Developmental & Cancer Biology, Portland, OR
Start Date: Spring of 2020
Job Summary:
This full-time (1.0FTE) position for a junior level PhD post-doctoral researcher will provide a mechanism for the hired individual to develop into a successful independent researcher in the fields of developmental neurobiology. The Nechiporuk lab uses zebrafish as a model system to study the formation of the peripheral nervous system. Our broad research focus is to discover mechanisms that lead to axon growth and circuit formation in the peripheral nervous system. The hired individual will use variety of modern approaches, including transgenesis, CRISPR-based genome editing, single-cell RNA sequencing (scRNA-seq), live imaging, and biochemical approaches, to dissect cell biological processes that drive axon growth during development.
Salary and Benefits:
The hiring salary for this position is set according to NIH guidelines.
Benefits include medical and dental insurance as well as retirement benefits.
Minimum Qualifications:
• PhD in life sciences such as genetics, anatomy, biology, biochemistry, or related field
• Ability to work independently within a research lab
• Strong technical research skills and reasoning ability
• Strong planning and organizational skills
• Excellent written and verbal communication skills
• Ability to manage time effectively while concurrently working on multiple projects
Preferred Qualifications:
• Prior experience with zebrafish is desirable but not required
• Prior experience with transgenesis, CRISPR genome editing method
• Prior experience with in situ hybridizations, immunostaining or similar detection methods
· Prior experience with live imaging and microscopy
· Knowledge of R programming
Interested individuals should email their CV, short statement of research interests, and the names and contact information for three references to Alex Nechiporuk (nechipor@ohsu.edu)
Northern Arizona University invites applications for a tenure-track assistant professor position in Molecular Genetics in the Department of Biological Sciences, with an expected start date of August 2020.
The position is broadly defined and candidates may include researchers that leverage human cells/tissue or model organisms as a research focus to address developmental, physiological, genetic, epigenetic and environmental interactions in generating phenotypes, de novo pathway construction, and mechanisms of regulation across levels of biological organization. Candidates that employ wet bench, bioinformatic, and evolutionary approaches (e.g., cellular and molecular techniques, transcriptomics, genomics, metagenomics, metabolomics, comparative organismal evolution) to explore the molecular mechanisms of organism health and development are encouraged to apply. A successful candidate will: (1) contribute to the teaching mission of the Department of Biological Sciences to educate students and trainees in Biological and Biomedical Sciences, including through mentoring of undergraduate, M.S. and Ph.D. students, and postdoctoral fellows; (2) maintain an independent research program that is supported by awards from extramural agencies; and (3) perform service for the department, university, and profession.
Review of will begin November 25
Minimum Qualifications: PhD in biological sciences or a closely related field; Minimum one-year post-doctoral research experience as of August 2020; Demonstrated experience as an effective classroom teacher.
Northern Arizona University is a committed Equal Opportunity/Affirmative Action Institution.