The division of Basic Sciences at the Fred Hutchinson Cancer Research Center invites applications for an open faculty position at the Assistant Professor level in the Division of Basic Sciences. We seek an exceptional laboratory scientist conducting fundamental research into mechanisms that regulate the basic biology of normal or cancer cells. Current faculty members investigate diverse areas of molecular, computational, cellular, developmental, evolutionary and structural biology, metabolism, virology and immunity. We utilize a broad range of experimental and computational approaches and model systems. Fred Hutch provides outstanding colleagues, a collegial atmosphere, and a wealth of resources to support junior faculty success. Graduate students are drawn from the outstanding Molecular and Cellular Biology graduate program at the University of Washington. Fred Hutch is located in a modern campus by Lake Union in Seattle, Washington, and is close to other non-profit research institutes and the University of Washington.
For information on the application process see our ad: https://apply.interfolio.com/67776
Deadline: Oct. 31, 2019
A full time Post-Doctoral research position is available in the laboratory of Dr. Charles Hong at the University of Maryland-Baltimore immediately. MD, PhD or MD/PhD scientist is sought to join the emerging field of chemical genetics. The Hong lab has identified a number of small molecules that specifically perturb embryonic patterning and well as genetic mutations that cause cardiovascular defects. We have number of projects to determine how these small molecules function by identifying their cellular targets using cell biological, biochemical and computational approaches. In addition, since aberrant activities of many of developmental pathways are thought to play a major role in pathogenesis of variety of human diseases, such as cancer, metabolic and cardiovascular diseases, an important goal is to explore therapeutic potential these small molecules in various zebrafish and murine disease models. Applicants are required to have a Ph.D. or M.D. and expertise in techniques of cell and molecular biology, and zebrafish experience is preferred. Depending on background and interest, the post-doc will perform experiments involving zebrafish development, drug target identification, proteomics, biochemistry, computational biology and/or murine or zebrafish disease models. Prior experience in these methodologies and willingness to learn new techniques are highly valued.
If interested, please email a CV, a short statement of research interests, and the names and contact information for three references to Charles Hong, MD, PhD at
Email: charles.hong@som.umaryland.edu.
University of Maryland is an Equal Opportunity Employer encouraging excellence through diversity. Qualified woman and minority candidates are encouraged to apply.
Our Company
NemaMetrix Inc. is a fast-paced, biotechnology company whose mission is to enable scientists and researchers around the world to better understand human health by offering a more affordable and accessible platform. We develop solutions for the genetic modification of C. elegans and D. rerio (Zebrafish) to act as human proxies for disease research and drug discovery and help our customers reveal new insights into the true nature of genetic mutations.
NemaMetrix is headquartered in Eugene, Oregon with a satellite office located in Salt Lake City, Utah.
Role: Molecular Biology Scientist
Location: Eugene, OR
Overview:
Working as part of our Research & Development team, this role’s principal focus is to deliver the necessary biological constructs, such as plasmids, to downstream teams for the creation and ultimate analysis of transgenic C elegans and Zebrafish. The incumbent will oversee most of the day to day lab activities including scheduling, daily/weekly prioritization, data collection, reprocessing, training, development of and adherence to SOPs, maintenance requests, and related activities.
What You’ll be Doing:
Designing and generating constructs for CRISPR mediated insertion of disease relevant genetic mutations, transgenic reporters and protein tags into model organisms, primarily Zebrafish.
Applying standard and advanced molecular biology techniques for detecting precise edits in vivo (insertion & integration).
Generation and propagation of de novo genome edited animals.
Identifying and troubleshooting innovative technologies to validate design and capture integration events.
Working independently and within a team to meet commercial project schedules, to optimize timelines and increase workflow of the engineering pipeline.
What You Bring to the Table: NemaMetrix is looking for individuals that possess a positive can-do attitude, are motivated by doing a job well, are adaptable and flexible, have a continuous improvement mindset and will thrive in a fast-paced collaborative and diverse environment. In addition, successful candidates will have the following:
Required Qualifications
PhD in Molecular Biology or a related field; Or BS or MS with 8+ years of experience.
Hands on experience with CRISPR genome editing methodologies, specifically with zebrafish.
Demonstrated success with site directed mutagenesis and homology driven repair.
Functional knowledge of advanced homology based cloning methods such as Gibson Assembly, Golden Gate or Infusion.
Proficient in standard molecular and biochemistry analysis.
Ability to design and build plasmids and transgenic constructs.
In-vitro transcription and RNA purification.
DNA and RNA Sequence Analysis.
Zebrafish Husbandry and Genotyping experience.
Preferred Qualifications
Proficiency with Morpholino design and microinjection
Familiarity with the tol2 transposon system
Molecular Phenotyping using qPCR analysis
Experience with Western Blotting, specifically in Zebrafish
Ability to design and interpret High Resolution Melting (HRM) analyses
Clinical Genetics experience
Perks of Working with Us
In addition to our friendly and collegial staff, NemaMetrix offers a benefits package that includes:
Medical, Dental, Vision and Life/AD&D insurance
401k plan
Paid Time Off
Flexible work schedules
Employee Events – including Summer BBQs, community service and holiday related events.
Dog friendly work environment in our Eugene, OR office
Our Commitment to You
NemaMetrix is an equal opportunity employer. NemaMetrix recruits, employs, trains, compensates and promotes individuals regardless of race, religion, color, national origin, sex, disability, age, sexual orientation, gender identity, veteran status, and any other protected category as required by applicable law.
Our dedication to promoting diversity, multiculturalism, and inclusion is clearly reflected in our content and across all our efforts. Diversity is more than a commitment at NemaMetrix—it is the foundation of what we do. We are fully focused on equality and believe deeply in diversity of all the fascinating characteristics that make us different.
We are looking for a qualified and experienced research technician with expertise in zebrafish husbandry, breeding, egg injection, morpholino oligonucleotides, genotyping, histology, and behaviors. A recently graduated MSc or PhD student who studied zebrafish and neuroscience is preferred.
We are looking for a Canadian or a permanent resident living in Ontario. Applications from non-Canadians or non-permanent residents will not be considered.
If selected, you will be part of the Brain & Breathing Science lab at the Keenan Research Centre for Biomedical Sciences at St. Michael's Hospital and University of Toronto. Information can be found here: www.gasplab.com
The position comes with health, dental benefits and may be long-term position depending on the fit.
If you are motivated, fun and independent, do not hesitate to send us a cover letter and resume at gasp.lab@gmail.com
Thanks for your interest.
Gaspard Montandon
Post-Doctoral Fellow position - University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City
The Frazer lab at the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City seeks a post-doctoral fellow. We study lymphoblastic leukemias & lymphomas using zebrafish models and in vitro tissue culture, with emphasis on the genetic events underlying oncogenesis and therapy resistance. My lab belongs to the Depts. of Pediatrics, Cell Biology, and Microbiology & Immunology, and the OUHSC Stephenson Cancer Center, and we have 7 full-time members.
A fun, motivated, independent, and creative person is a perfect fit for our group. I am committed to mentoring you to achieve your career goals. Projects you develop as a post-doc can be taken upon leaving the lab. Applicants need a PhD and/or MD, and experience with zebrafish, genetics, and/or molecular biology are plusses.
OUHSC has a large campus with multiple schools (graduate, medical, dental, allied-health, nursing, etc.). Our lab is well-equipped, with strong core facilities available. We have an aquatic facility manager who coordinates fish care, breeding, IVF, etc., so you can focus on experiments.
Oklahoma City is the 27th largest US city (~1.3 million people) and Oklahoma’s capital. It has diverse cultures & ethnicities, as does our lab. OKC’s cost of living is very low, so post-docs can live well here. Please contact me by email & attach your CV if you’d like to discuss the position further.
We are looking for a highly motivated and dynamic researcher for a one year position, to commence Jan. 1st, 2020.
Our research
Our main research interest is molecular and genetic mechanisms of cardiac development and congenital heart disease. We are using a multidisciplinary approach, where we combine genetic and genomic investigations of patients, with functional investigations based on embryonic tissues, cell models and zebrafish. Our ambition is to perform research on the highest level and publish in high-quality international journals. We have a very inclusive working environment and a large network of national and international collaborators. More information about our research can be found at:
https://icmm.ku.dk/english/research-groups/la-larsen-group/
Information on Department of Cellular and Molecular medicine can be found at: https://icmm.ku.dk/english/
Your job
Your project will focus on functional characterization of candidate disease genes identified in patients with congenital heart defects. Preferably, the functional characterization of cardiac developmental genes should be performed using zebrafish and cell models. Consequently, the project will include standard methods for gene targeting in zebrafish (i.e. morpholino and CRISPR-cas9 based gene targeting) and phenotypic characterization of heart defects. Thus, documented expertise in zebrafish developmental biology will be an advantage.
Detailed information about the position, including how to apply, can be found at: https://employment.ku.dk/all-vacancies/?show=150510
For further information please contact Prof. Lars Allan Larsen (larsal@sund.ku.dk).
A postdoctoral position at the University of Pittsburgh to study the expression regulation of polarity genes in zebrafish
We are looking for a self-motivated postdoc to study the expression regulation of polarity genes by using recombinant DNA technologies, RNA and DNA FISH, immunohistochemistry, confocal microscopy, and transgenic zebrafish etc. Candidates should have a PhD in developmental biology, genetics, molecular biology, or cell biology. Applicants shall send a cover letter and a CV to Dr. Xiangyun Wei atweix@upmc.edu (Xiangyun Wei, Ph.D., Associate Professor, University of Pittsburgh School of Medicine, Pennsylvania, United States)
It is highly recommended that the applicants discuss his or her research interests on Wei lab’s publications by email. Five representative papers are listed as follows:
X. Wei, J. Samarabandu, R.S. Devdhar, A. Siegel. R. Acharya, R. Berezney. (1998) Segregation of transcription and replication sites into higher order domains. Science. 281:1502-1505.
The Buckley lab at the department of Physiology, Development and Neuroscience (PDN), University of Cambridge is recruiting a Research Assistant or Research Associate to help further develop their optogenetic technology. The lab uses optogenetic and live confocal imaging approaches within the whole zebrafish neural tube and mammalian embryo stem cell (mESC) culture to manipulate the polarity of single cells. In combination with CRISPR-mediated functional knock down experiments, we are directly testing the role of cell polarity in building epithelial integrity during organ development and breaking in it during normal developmental processes such as EMT and during abnormal disease states.
The post is for 1 year in the first instance from early 2020 and funding is available for potential contract extension.
For full details see: https://urldefense.com/v3/__http://www.jobs.cam.ac.uk/job/23220/__;!5W9E9PnL_ac!UCzkYjy_WRtKNktAf9V1IVKWiZBnx8kwF7Mum7_CakV9Q5TJ9Ey9tkZJ9VW9iy8J$
Informal enquiries can be addressed to Dr Clare Buckley at ceb85@cam.ac.uk.
Leukodystrophy Disease Pathology and Therapeutics
A position for a postdoctoral fellow is available for studies on leukodystrophy disease gene pathophysiology and therapeutics discovery in the Bonkowsky lab (http://medicine.utah.edu/pediatrics/labs/bonkowsky/). The experimental model systems include mouse, zebrafish, and human (see paper by Strachan et al., 2017, Human Molecular Genetics). Projects in gene therapy and small molecule development are part of the project.
Qualifications: PhD or MD/PhD. Strong background and experience in experimental sciences (such as molecular biology and/or biochemistry) is necessary. Prior experience in genetics, developmental biology, neuroscience, sequencing, programming, and imaging would be advantageous. Experience in animal models of disease strongly recommended.
Candidates should be ambitious and independent with good communication skills and team mentality; and at least one first-author publication in a well-respected journal.
The lab and setting are an innovative, well- equipped and scientifically stimulating surrounding. Initial employment and funding contract is for one year (renewable) with standard NIH pay scale. Applicants should be able to apply for external (NIH or private foundation) funding.
Women and under-represented minorities are especially encouraged to apply. The University of Utah is an Equal Opportunity Employer.
Applications should include a ½ page letter of description of their research interests and career goals, a CV, and the names and contact information of three academic references, and be sent to:
Dr. Josh Bonkowsky
E-Mail: joshua.bonkowsky@hsc.utah.edu
The Francis Crick Institute
Early Career Group Leader programme
The Francis Crick Institute is a new biomedical discovery research institute in central London dedicated to understanding the biology underlying health and disease.
We are core-funded by Cancer Research UK, the Medical Research Council, and the Wellcome Trust.
Explore the Crick's research interests at https://www.crick.ac.uk/research
We seek creative and innovative individuals to establish new research programmes in:
All areas of biology and biomedicine (of particular interest are cancer and immunity and infection)
We are also looking for people interested in cardiac and vascular biology (special initiative, supported by the British Heart Foundation)
The Crick research environment
- 120 research laboratories
- Comprehensive Science Technology Platforms (STPs)
- Animal husbandry and imaging
- 250 graduate students, 400 postdocs
Our Package
- Initial 6-year contract, renewable, to total 12 years
- Salaries and consumables for up to five researchers, including graduate students
- Opportunity to expand through external grant funding
- Ready access to Crick STPs
- Full lab setup in state-of-the-art laboratory space
- Package applies to duration of contract
Further information on Early Career Group Leaders can be found at:
https://www.crick.ac.uk/careers-and-study/faculty
Apply online at: https://academicrecruitment.crick.ac.uk
Informal enquiries about The Francis Crick Institute or the application procedure can be made at: Group-leader-recruitment@crick.ac.uk
Applications by midnight (GMT), 10th October 2019
(Recruitment symposia in December and January 2020)