The Department of Biological Sciences, University of Toronto Scarborough (UTSC) invites applications for a tenure-stream appointment in the area of Zebrafish Biology. The appointment is at the rank of Assistant Professor and will commence on July 1, 2020, or shortly thereafter.
Candidates must have a PhD in the Biological Sciences or a related field, at least one year of postdoctoral experience, an outstanding research record and a strong commitment to excellence in teaching at the undergraduate and graduate levels. The successful candidate must use zebrafish to study fundamental biological questions using the latest technological approaches. We are particularly interested in candidates who will create synergies with existing zebrafish research within the department and will complement and deepen our existing departmental strengths. Research areas and technological approaches of the successful candidate may include, but are not limited to:
- Developmental Neurobiology
- Behavioral Neuroscience
- CRISPR/Cas9 disease modeling
- Use of genomic and transcriptomic approaches
The successful candidate will be expected to conduct innovative and independent research at the highest international level and to establish an outstanding, competitive, and externally funded research program. Applicants must have a record of excellence in research, as demonstrated by publications in top ranked and field-relevant academic journals, presentations at significant conference, awards and accolades for work in the field, an innovative research statement and strong endorsements by referees of high international standing. The successful candidate will also have a strong commitment to excellence in teaching at both the undergraduate and graduate level. A commitment to excellence in teaching will be demonstrated through the statement of teaching philosophy, teaching accomplishments, and evidence of superior performance in teaching-related activities documented in the submitted teaching materials. Documented teaching excellence may include performance as a teaching assistant or course instructor, experience leading successful workshops or seminars, student mentorship, or conference posters or presentations, as well as strong letters of reference. The successful candidate is also expected to show evidence of a commitment to equity, diversity, inclusion, and the promotion of a respectful and collegial learning and working environment, demonstrated through the application materials. Salary will be commensurate with qualifications and experience.
Further information on the research and teaching activities of the department can be found at https://urldefense.com/v3/__http://www.utsc.utoronto.ca/*biosci/__;fg!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2mZJfs2N$ .
The University of Toronto is an international leader in biological research and education and the Department of Biological Sciences enjoys strong ties to other units within the University. The successful candidate will cross appointed to the Graduate Department of Systems and Cell Biology at the University of Toronto (https://urldefense.com/v3/__http://csb.utoronto.ca/__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2j43ksy8$ ), and expected to maintain an active research program centered at the University of Toronto Scarborough, and to foster and facilitate inclusivity while working in one of Canada's most diverse institutions. At UTSC, the new faculty member will have access to several research facilities including state of the art molecular, cellular, neuroscience, and imaging tools in the Centre for the Neurobiology of Stress (https://urldefense.com/v3/__https://www.utsc.utoronto.ca/cns/__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2ri2q7t5$ ) and the outstanding chemistry analytical capacity offered by the TRACES Lab (Teaching and Research in Analytical Chemical and Environmental Science -https://urldefense.com/v3/__http://www.utsc.utoronto.ca/*traceslab/__;fg!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2o89mD_P$ ).
All qualified candidates are invited to apply at this link . Applications must include a current CV, a cover letter, a statement of research, three representative publications, a statement of teaching philosophy, and other teaching materials showing evidence of excellent performance in teaching related activities as listed above. Submission guidelines can be found at: https://urldefense.com/v3/__http://uoft.me/how-to-apply__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2mJzFBPZ$ . We recommend combining attached documents into one or two files in PDF/MS Word format. Applicants must also arrange that letters of reference (on letterhead, signed and scanned) from at least three referees familiar with the candidate’s research and teaching be emailed directly by the referee to: biologygeneral@utsc.utoronto.ca by the closing date. Applications lacking reference letters will not be considered. If you have questions about this position, please email biologygeneral@utsc.utoronto.ca. All application materials, including reference letters, must be received by December 2, 2019.
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see https://urldefense.com/v3/__http://uoft.me/UP__;!5W9E9PnL_ac!SMPD0FZskTOkuvGGm9y8o4pi9X4UzB1qgU6N-yObZuZULSov8p8yAiaS2rZPVte_$ . All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.
Full Time, 2 years.
Salary: According to experience
Closing Date: 30th of October 2019
Starting Date: 1st February 2020
A postdoctoral position is open in the “Development of Mucosal Immunity and Tissue Integrity Lab” headed by Pedro Hernandez at the Genetics and Developmental Biology Department of Institut Curie in Paris, France.
Our team focuses on identifying and characterizing immune signaling mechanisms regulating intestinal epithelial development and function. The zebrafish offers significant experimental advantages including high fecundity, external development, easy genetic manipulation, small size and transparency. We are combining these advantages with flow cytometry, bulk and single-cell transcriptomic profiling, live microscopy and immune challenges.
We are looking for a highly motivated candidate with a strong interest in interdisciplinary research combining developmental biology and immunobiology. The candidate will manage a research project with focus on understanding the role of cytokine signaling in mucosal tissues such as the intestinal epithelium upon various types of stress.
The candidate will benefit from the top-level scientific environment of Institut Curie, and of state-of-the-art technological platforms. The lab is located in the Curie campus in the heart of Paris providing interdisciplinary expertise and a very friendly and international environment.
Specific requirements
PhD in biological sciences
Experience working in immunology or developmental biology
Highly talented and motivated researcher
Know-how with zebrafish will be an advantage but is not mandatory
Proficiency in bioinformatics and transcriptomics would be a plus
Expertise in molecular and cell biology
Initiative in planning, organizing and designing innovative experiments
Fluency in both spoken and written English
Application
Please send: CV including publications, a statement of interest, and the names and email addresses of 2-3 potential referees to pedrohernandezlab@gmail.com indicating “LASTNAME_Postdoc application” in the subject. For further queries: pedro.hernandez-cerda@curie.fr and visit our website
Department: Biochemistry and Biophysics, Dr. Colin Johnson
Position percentage: 100%
Appointment Basis: 12 Months
Location: Corvallis, Oregon
Anticipated Appointment Begin Date: 1/1/2020
Anticipated Appointment End Date: 2021, possibility of yearly renewal
Posting Date: 9/11/19
Full Consideration Date: 12/1/2019 or until position filled
Contact: colin.johnson@oregonstate.edu
Posting Date
POSITION DESCRIPTION
Department of Biochemistry and Biophysics, Oregon State University
Job title: Postdoctoral Researcher.
Position title: Postdoctoral scholar (postdoc)
A postdoctoral position is open to work on the molecular and cellular biology of zebrafish neuromasts. The appointee will work with Dr. Colin Johnson (Department
of Biochemistry and Biophysics). The position will be renewed on a yearly basis. The successful candidate will be appointed as a postdoctoral scholar.
Responsibilities:
- Zebrafish husbandry
- Characterize zebrafish mutants using confocal microscopy
- Characterize gene expression in zebrafish and zebrafish mutants using PCR methods
- Publish the research results in peer-reviewed high-impact scientific journals.
- OSU at scientific meetings by presenting original research.
- Take the initiative in finding solutions to scientific problems that arise in day-to-day
research.
- Collegially engage in collaborative work with peers with the aim to achieve the above
objectives.
Minimum Qualifications for a Postdoctoral Scholar include:
- PhD in Biochemistry, Cell Biology or related field.
- Demonstrated creativity, independence, high motivation, and good communication skills,
both orally and written.
- Strong work habits and the ability to work independently as well as with research group.
Preferences:
- Experience in CRISPR methodology
- Experience in immunofluorescence
- Experience in western blot analysis
- Experience in qPCR methodology
- Experience in zebrafish husbandry
- Experience in developing publications based on individual research.
The Department of Molecular, Cellular, and Developmental Biology (MCDB) in the College of Literature, Science, and the Arts at the University of Michigan solicits applications for faculty positions at the assistant professor level, but appointment at a more senior level is possible for applicants with suitable experience. The faculty position will be tenured or tenure track with a university year appointment starting September 1, 2020 or January 1, 2021. Successful candidates will be expected to establish a vigorous, extramurally funded research program and to be involved in instruction of both undergraduate and graduate students.
We welcome applications from outstanding biologists in the areas of biochemistry, developmental biology, and neuroscience. Researchers working on either plants, microbial, or animal systems are encouraged to apply. Experimental approaches that are desired include (but are not limited to) genetics, genomics, structural biology, enzymology, physiology, in vivo imaging, and single cell technologies. For further information about MCDB research areas and the goals of this faculty search, please visit lsa.umich.edu/mcdb.
All applications must be submitted on-line.
https://apps-prod.mcdb.lsa.umich.edu/search19/howtoapply.php
You will be asked to upload the following materials: A cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, a statement of teaching interests and philosophy, and evidence of teaching excellence for those who have teaching experience. Candidates for appointment as an assistant professor should provide names and contact information for at least three references, as instructed in the on-line application form. To ensure full consideration, all materials should be received by October 19, 2019.
Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.
A postdoctoral position is available in the Sam Sidi laboratory, Mount Sinai Medical Center, Manhattan, New York. Mutational damage to genomic DNA both drives the progression of cancer and remains the main mechanism by which we treat the disease (i.e., via radiotherapy or chemotherapy). p53 signaling, which controls DNA repair vs. apoptosis decisions in damaged cells, has long dominated research into how cells respond to DNA injury. However, p53 signaling is almost universally lost during oncogenesis via mutational inactivation of p53 itself or that of its activators or effectors.
To both discover new biology in the DNA damage response and define viable therapeutic strategies in cancer, we have conducted large-scale screens for genetic and chemical suppressors of mutant p53 in zebrafish. These efforts have led to the discovery of novel targets for inhibition in p53mutant cancers (e.g., Chk1 and IRAK1 kinases) and to the identification of an alternative apoptotic axis anchored by the PIDDosome complex (PIDD-RAIDD-caspase-2) which retains full functionality in p53-deficient vertebrate cells (see references 1-5 below).
The successful applicant, an experienced zebrafish researcher with a minimum of basic training in human cell culture biochemistry (e.g., co-IP), will focus on one of several areas currently under investigation:
1. Genetic dissection of the novel, IRAK1-mediated anti-apoptotic response to radiation therapy (ref. 1). Focus on the molecular events upstream, at the level, and downstream of radiation-induced IRAK1 activation. This research is poised to unveil novel drug targets for overcoming resistance to radiotherapy in the million+ patients who fail to respond due to p53 mutation. Such “radiosensitizing” drugs are essentially unavailable and are direly needed in the clinic.
2. Biochemical analysis of a novel, p53-independent molecular switch that decides cell survival or death in response to DNA interstrand crosslinks (ICL). We have recently identified a DNA repair molecule with the ability to sense ICL repair failure and trigger apoptosis as a result (Shah and Sidi, unpublished). This is to our knowledge the first described example of a repair/apoptosis switch, with the potential to define a new paradigm in tumor suppression.
3. Functional analysis of novel regulators of PIDDosome signaling, as recently identified in the lab via RNAi screens and mass spectrometry. Three validated, potentially direct regulators of the complex are available for immediate analysis using combinations of genetics, biochemistry and imaging in zebrafish embryos and cultured human cancer cells (as in refs. 1-4). These projects will both extend our understanding of a novel apoptotic axis in vertebrates, clarify its significance and evolutionary origin, and identify new means to unleash its activity in p53 mutant tumors.
The applicant will take advantage of the vibrant and cutting-edge environment at Mount Sinai and work with our collaborators in world-class bioinformatics, genomics, microscopy, medicinal chemistry and pharmacology departments. The applicant will also participate in new screening efforts in zebrafish for novel drivers and druggable targets in radioresistant and chemoresistant cancer (as in refs. 1 and 5).
Please send cover letter and CV (including a minimum of two reference contacts) tosamuel.sidi@mssm.edu
For more information, please check out our lab websites/media and relevant publications.
http://labs.icahn.mssm.edu/sidilab/ http://psscra.org/winners/samuel-sidi-phd/
http://www.searlescholars.net/person/575 https://www.youtube.com/watch?v=LnyxoxvtcPo
1. Liu PH, et al. An IRAK1-PIN1 signaling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol 21:203-213, 2019.
2. Ando K, et al. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. J Cell Biol 216:1795-1810, 2017.
3. Thompson R, et al. An inhibitor of PIDDosome formation. Mol Cell 58:767-779, 2015.
4. Ando K, et al. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 47:681-693, 2012.
5. Sidi S, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2 and caspase-3. Cell 133:864-877, 2008.
Description of the project
The research conducted by our group focuses on the study of neuropeptides in the urotensin II (UII) family. They aim to better understand the functions exerted by these peptides and to characterize more finely the neurons that produce them, especially those located in the spinal cord. For this, we use zebrafish as a study model.
In recent months, we have generated a series of transgenic fish reporter lines labeling the neurons that produce peptides of the UII family. These lines will be used to develop two projects:
1) to determine the origin of the UII-ergic neurons and to characterize the networks in which they take place in the embryo and then the zebrafish larva
2) to isolate these neurons by FACS in order to establish their transcriptome.
The candidate to be recruited will participate in each of these two projects.
Location
National Museum of Natural History, Paris France
Development and Evolution of Neurosecretory Systems (team leader: Hervé Tostivint)
Lab website: https://umr7221.mnhn.fr/?lang=en
Candidate profile
The candidates should be highly motivated and able to work both independently and in a collaborative environment, with a strong commitment to achieving assigned objectives. The successful candidate will have a good background in neuroscience and / or developmental biology. An experience in imaging and FACS will be appreciated, as well as a familiarity with the zebrafish model.
Appointment
The position is temporary for 1 year but may be extended pending on grant applications.
Net salary
2360 euros/month
Starting date
January 2020
Applications
To apply, please send your CV, motivation letter stating your research interests/plans and the names/contact information of 2/3 referees to htostivi@mnhn.fr
The Section of Ecology, Behavior and Evolution in the Division of Biological Sciences (www.biology.ucsd.edu) invites applications for a faculty position at the tenure-track Assistant Professor or tenured Associate or Full Professor level. Competitive candidates will investigate evolutionary questions through mechanistic studies of the developmental or physiological processes that produce phenotypic variation. Research topics could include, but are not limited to: evolutionary innovation; developmental constraints; phenotypic plasticity and genetic accommodation; and the evolution of genotype-phenotype maps. We welcome applicants incorporating laboratory, field, and/or theoretical components in their research.
The Division of Biological Sciences at UCSD is a vibrant center of scientific discovery, innovation, and collaboration. Our large research base spans many areas of biology and has one of the most celebrated graduate programs in the country. We are committed to academic excellence and diversity within the faculty, staff, and student body.
All candidates must have earned a Ph.D. or equivalent degree, and be committed to teaching at the undergraduate and graduate levels. Associate and Full Professor candidates must possess strong leadership skills. In addition to excellence and creativity in research and scholarship, successful candidates must also demonstrate a commitment to equity and inclusion in higher education. We are especially interested in candidates who have created or contributed to programs that aim to increase access and success of underrepresented students and/or faculty in the sciences, and/or have detailed plans to accomplish such goals.
Salary is commensurate with qualifications and based on University of California pay scales.
Initial review of applications will commence on October 28, 2019 and will continue until position is filled.
Interested applicants must submit a cover letter, curriculum vitae, statement of research, statement of teaching, a statement describing their past experience and leadership in fostering equity and diversity and/or their potential to make future contributions, and 3-5 publications. For information on preparing diversity statements and divisional initiatives to promote diversity, see: http://facultyequity.ucsd.edu/Faculty-Applicant-C2D-Info.asp and http://biology.ucsd.edu/diversity/index.html. Applicants at the Assistant Professor level need to submit 3-5 references, and applicants at the Associate or Full Professor level need to provide contact information for 3-5 references.
Applications must be submitted through the University of California San Diego’s Academic Personnel RECRUIT System:
Assistant Rank: https://apol-recruit.ucsd.edu/JPF02235
Associate or Full Rank: https://apol-recruit.ucsd.edu/JPF02236
Further details about the required application material can be found at: http://biology.ucsd.edu/jobs/apply-lrf-lsoe.html
UCSD is an Affirmative Action/Equal Opportunity Employer with a strong institutional commitment to excellence through diversity (http://diversity.ucsd.edu/). All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, sexual orientation, national origin, disability, age or protected veteran status.
The Department of Developmental Biology at Washington University in School of Medicine invites applications at the level of assistant professor on the tenure track. We are seeking outstanding colleagues with an interest in any area of developmental biology, including the genetic and epigenetic mechanisms of embryogenesis, cell fate specification and reprogramming, regeneration, aging, tissue engineering and quantitative approaches to developmental biology. Faculty in the Department of Developmental Biology employ a broad range of cell culture systems and model organisms including human embryonic stem cells, C. elegans, D. melanogaster, zebrafish and mouse. For more information, please visit our website at http://devbio.wustl.edu/.
Review of applications will start October 15, 2019. Interested applicants are required to submit their cover letter, curriculum vitae, and summary of their research accomplishments and plans through the online application website found at https://facultyopportunities.wustl.edu/apply/Posting/Detail/1010397.
Applicants should also be prepared to provide the names and email contact information for three referees to provide letters of recommendation during the application process.
Washington University seeks an exceptionally qualified and diverse faculty; women, minorities, protected veterans and candidates with disabilities are strongly encouraged to apply.
Reference Code
EPA-SSP-0008-20-9-9-2019
How to Apply
Ready to send share your interest with EPA scientists?
Submit application and supporting documents by clicking on Apply Now button. https://zintellect.com/Opportunity/Details/EPA-SSP-0008-20-9-9-2019
Questions:
For more information, contact EPAjobs@orau.org. Check our website at https://www.orau.org/epa/
Description
The EPA Environmental Research and Business Support Program has an immediate opening for a full-time doctorate level Microbial Zebrafish Research Scientist with the EPA facility in Cincinnati, OH.
What the EPA project is about
The Office of Research and Development (ORD) functions as the principal scientific component of the U.S. Environmental Protection Agency (EPA).
The National Exposure Research Laboratory (NERL), Office of Research and Development (ORD), Systems Exposure Division (SED), located in Cincinnati, Ohio, is a scientific organization responsible for carrying out EPA’s mission to protect human health and the environment by developing and applying innovations in exposure science. Currently a research effort for ORD is developing methods for microbial contaminants of emerging concern (CECs) for whom we lack data. Species of Legionella and Mycobacterium are drinking water microbial CECs and are on the US EPA’s Office of Water’s Contaminant Candidate List 4 (https://www.epa.gov/ccl/contaminant-candidate-list-4-ccl-4-0). Several studies have described the occurrence of Legionella and mycobacteria in drinking water, but the lack of genetic virulence determinants and absence of in vivo animal models limit our understanding of the infectivity of environmental isolates and their subsequent risk towards humans. Zebrafish embryos possess innate immunity, which is the same component of the immune system that Legionella and mycobacteria disable in humans. In addition, fluorescent-transgenic zebrafish lines are commercially available that provide the ability to follow the infectious process in real-time. Zebrafish embryos have successfully been used to characterize the role of the innate immune system in dissemination of M. tuberculosis infection (doi: 10.1016/j.cell.2008.11.014) and to establish the virulence of M. abscessus isolates from cystic fibrosis patients (doi/10.1073/pnas.1321390111). While these limited studies have characterized the virulence of human isolates, it is not known if environmental isolates exhibit virulence in vivo. Key objectives for this research effort are:
- Establish the zebrafish embryo as a model for measuring virulence of relevant species of Legionella and mycobacteria and
- Estimate in vivo virulence of drinking water isolates of mycobacteria and Legionella to better understand their risk to human health.
Legionella have been identified as a high priority research area in Office of Water’s Research Priorities Document (2018). In addition, this research will provide critical data in support of EPA’s Strategic Plan, Objective 3.3, to “support safe drinking water by focusing research on assessing the distribution, composition, remediation, and health impacts of known and emerging chemical and biological contaminants.”
What you will be doing
As a team member, you will assist the ORD NERL Methods for Microbial CECs research team with the research and administrative duties required to fulfill its commitments to methods development for environmental microbial CECs in support of Office of Water’s Contaminant Candidate List 5 (CCL5) and Unregulated Contaminant Monitoring Rule (UCMR).
Required skills
- Demonstrated laboratory experience in growth of bacteria and preparation of inocula for microinjection.
- Demonstrated laboratory experience maintaining fish cultures using Standard Operating Procedures. Experience with breeding, collection of embryos, and preparation of embryos for microinjection.
- Advanced proficiency with Microsoft Office applications (i.e., Excel, PowerPoint, Word, Outlook, Access).
- Highly organized; experienced in administration support functions (i.e., recordkeeping, meeting organization) and managing records (electronic and paper).
- Strong communication skills (written and oral).
Desired skills
- Experience in fluorescent microscopy.
How you will apply your skills
Research responsibilities include:
- Performing general assistance in the laboratory, including the preparation of microbiological media, maintenance of cultures, processing water samples for DNA extraction and qPCR analysis;
- Growing and preparing bacterial suspensions for microinjection into zebrafish embryos;
- Using standard protocols to produce zebrafish embryos from established fish stocks;
- Preparing zebrafish embryos for microinjection with bacterial suspensions;
- Using stereomicroscopy for visualizing the infection process in zebrafish embryos;
- Performing data management activities;
- Documenting methods and quality assurance/quality control procedures employed in a laboratory notebook; and
- Drafting written material (including text, tables and figures) to describe the methods and results of the scientific process undertaken to address key research questions related to virulence of environmental bacteria.
Management and Administrative responsibilities include:
- Gathering information and developing tables, spreadsheets, presentations, and graphics in response to needs of the research team;
- Assisting the mentor in addressing a variety of research team needs using expertise and ability to collaborate with colleagues and other researchers in a professional environment;
- Establishing and maintaining a variety of electronic files and laboratory notebooks; and
- Taking and documenting all required training courses, including laboratory safety, Quality Assurance/Quality Control, and EPA mandatory training courses.
Communication related responsibilities include:
- Assisting in responding to requests of various nature that require short turn-around times and attention to detail;
- Working with the research team to gather information when required, perform a variety of analyses using computer programs, and communicate results clearly to staff; and
- Attending meetings, providing requested feedback on data calls, and communicating with ORD NERL management and the research team.
Location: This job will be located EPA’s Cincinnati, OH facility.
Salary: Selected applicant will become a temporary employee of ORAU and will receive an hourly wage of $41.95 for hours worked.
Hours: Full-time
Travel: Occasional overnight travel may be required.
Expected start date: The position is full time and expected to begin October 2019. The initial project is through May 14, 2020, with potential optional periods.
Qualifications
- Be at least 18 years of age and
- Have earned a PhD in biology, microbiology, environmental sciences, or a closely related field of study from an accredited university or college within the last 24 months and
- Be a citizen of the United States of America or a Legal Permanent Resident.
EPA ORD employees, their spouses, and children are not eligible to participate in this program.
Eligibility Requirements
- Citizenship: LPR or U.S. Citizen
- Degree:Doctoral Degree received within the last 24 month(s).
The Department of Biology with Eberly College of Arts and Sciences at West Virginia University is seeking applicants for a Research Assistant I. The position will support research in the Department of Biology (Horstick lab 75%, Bergeron lab 25%), with a focus on developmental and sensorimotor neurobiology using zebrafish. The incumbent will spend approximately 66% of their time performing support and maintenance to the Horstick and Bergeron labs' zebrafish colonies and systems, approximately 600 tanks, requiring some care over weekends and university holidays. In addition, the incumbent will spend approximately 33% of their time performing behavior assays, molecular biology techniques and imaging. The incumbent serves as a project coordinator. Intermediate technical and conceptual knowledge, as well as analytical skills, are required to successfully perform duties. The incumbent must independently use field-specific concepts and follow organizational procedures to solve moderate to complex problems. Work effort often addresses optimizing established protocols and potentially establishing new protocols, as well as supervising personnel assisting in the overall project. Finally, regular communication with the principal investigator should provide detail as to the progress of the project and next steps. Immediate start date preferred.
In order to be successful in this role, the ideal candidate will:
- Provide daily care and maintenance of zebrafish colony and aquatics facilities (requires maintaining detailed records, inspection of animals and equipment, equipment calibration, daily cleaning, preparation of stock solutions, maintenance of rotifer colony, daily feeding and life support, regular water quality testing, and fin biopsies)
- Respond to fish facility emergencies
- Carry out behavioral experiments in compliance with all safety protocols. This also may include troubleshooting and optimizing assays based on literature
- Attend weekly meetings discussing progress with supervisor and biweekly lab meetings to discuss ongoing projects in the lab.
- Perform laboratory experiment and animal/equipment care activities according to protocol. This includes independent experimental data analysis, maintaining detailed logs of work-related activities, including accurate laboratory records, and data on research methods, procedures, and results. Summaries of experimental outcomes and recommended future steps are also expected.
- Coordinate and train undergraduate students and new trainees performing related or contributing research and animal care.
- Stay current on best practices for experiments and zebrafish care as outlined by federal and university animal husbandry rules and guidelines
Pay Grade: 15
Qualifications
- Bachelor’s in Biology, Neuroscience or a related field is required.
- Six (6) months experience with:
- Working in a biology laboratory
- Analyzing data preferred
- Working in the area of molecular biology and neuroscience preferred
Requirements
- Resume
- Cover letter
Please go to the following link to apply:
About WVU
At West Virginia University, we pride ourselves on a tireless endeavor for achievement. We are home to some of the most passionate, innovative minds in the country who push their limits for the sake of progress, constantly moving the world forward. Our students, faculty and staff make this institution one of the best out there, and we are proud to stand as one voice, one university, one WVU. Find out more about your opportunities as a Mountaineer at https://talentandculture.wvu.edu/.
West Virginia University is an Equal Opportunity/Affirmative Action Employer and the recipient of an NSF ADVANCE award for gender equity. The University values diversity among its faculty, staff and students, and invites applications from all qualified individuals, including minorities, females, individuals with disabilities and veterans.
Neuroscience laboratory at the University of California, San Francisco (UCSF) seeks a qualified, experienced and dynamic Postdoctoral Fellow. The successful candidate will advance our program to use zebrafish in epilepsy research. Our laboratory developed and characterized the first acute (Baraban et al. Neuroscience 2005; Hunt et al. Exp. Neurol. 2012) and genetic (Hortopan et al. J. Neurosci. 2010; Baraban et al. Nat. Comm. 2013; Grone et al. PloS One 2016) models of epilepsy in zebrafish. We are currently using these models in high-throughput drug screening, neurodevelopmental, and calcium imaging projects. We are also using CRISPR/Cas9 gene editing technology to generate new zebrafish mutant lines for all known human epilepsy genes. Both projects are supported by grants from the National Institutes of Health.
Using larval zebrafish, we plan to establish new pipelines for the analysis and monitoring of seizures, as well as discover and develop new therapies for these genetic forms of epilepsy. Studies using larval zebrafish incorporate a variety of approaches already established in the lab: electrophysiology recording in vivo, locomotion tracking, pharmacology, CRISPR/Cas9 editing, qPCR, microfluidics, computational (MATLAB) analysis, light sheet microscopy, and fast confocal imaging of brain networks in fluorescent reporter fish. We are currently seeking a highly motivated individual to participate in these projects.
If you are interested in a postdoc position in our lab, send an email to scott.baraban@ucsf.edu that includes your CV and contact information for at least two references. Please also send a brief 1-page description of your research interests describing your past research experience, future goals, and how you envision your contribution to the overall research direction of the Baraban Lab. Competitive applicants will have:
- at least one first-author publication in a high-quality journal
- a sincere interest in epilepsy research
- zebrafish experience
Lab website: https://barabanlab.ucsf.edu/
Lab Twitter: https://twitter.com/barabanlab?lang=en
UCSF offers an outstanding neuroscience community and desirable San Francisco location.
Graduate student positions available to investigate the mechanisms underlying cardiac development and disease.
Our research investigates the fundamental question of how cardiac cells sense and respond to their environment. We seek to understand the mechanisms underlying the regulation of morphogenetic and identity transformations that occur during development and disease. We use the assembly of the heart tube in zebrafish as our model with which to elucidate these mechanisms. Some of the specific research questions we are interested in include: How do multiple tissues interact to regulate large movements and biomechanical force? How do dynamic changes in the extracellular matrix regulate cardiac morphogenesis? How is lumen formation intrinsically and extrinsically encoded? and How is the plasticity of cardiovascular identity regulated? To answer these questions, we take an interdisciplinary approach, combining the genetic and live-imaging strengths of zebrafish with both biomechanics and systems-level methodologies.
-More information about the laboratory can be found at thebloomekatzlaboratory.org.
If you are interested in joining our lab as a PhD student, please contact us directly at josh@olemiss.edu.
-Additional positions, including a rotation program, are also available in our interdisciplinary graduate program in the department of Biology at the University of Mississippi. For more information about our graduate program including rotations please see biology.olemiss.edu
Postdoctoral Position in zebrafish as a model of human diseases
A two year (extendable) fully funded (minimum NIH scale) postdoctoral position (junior or senior) is available in the Gibert Lab in the Department of Cell and Molecular Biology and Cancer Center and Research Institute at the University of Mississippi Medical Center (UMMC) in Jackson Mississippi (https://www.umc.edu/som/Departments%20and%20Offices/SOM%20Departments/Cell%20and%20Molecular%20Biology/For%20Faculty/Yann%20Gibert.html). The Gibert Lab takes advantage of the zebrafish to model multiple human genetic diseases (CRISPR/cas9).
Current areas of interests include: obesity, diabetes, metabolic disorders, endocrine disrupters and cancer
Our efforts are supported by a recently awarded discovery project (RO1 equivalent) from the National Health and Medical Research council (NHMRC Australia, NIH equivalent) and a generous start up package form UMMC
REQUIRED QUALIFICATIONS:
PhD degree required. Applicants must be highly motivated and technically accomplished as documented by exceptional publication record. Candidates must have demonstrated experience in molecular biology and CRISPR/cas9 technology. Experience with zebrafish embryogenesis in mandatory.
UMMC has a large campus with multiple schools (graduate, medical, dental, allied-health, nursing, etc.). Our lab is well-equipped, with strong core facilities available. We have a state-of-the art Techniplast aquatic with dedicated personals to look after the fish and embryos so you can focus on experiments.
Jackson is located in the heart of the south with the most welcoming people in the country and plenty of outdoor activities available and low cost of living
TO APPLY:
Please email CV and reprints of relevant publications to the contact information below. Applicants accepted for initial consideration will be subsequently contacted for letters of reference.
Expected starting date: fall/winter 2019
Yann Gibert, PhD
Associate Professor
Department of Cell and Molecular Biology and Cancer Institute
University of Mississippi Medical Center
Jackson, MS
e-mail: ygibert@umc.edu