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Our laboratory studies the relationship between chromatin regulation, transcriptional changes and phenotypic outcomes using the zebrafish. We have shown that loss of the chromatin modifier kdm2aa causes multiple defects, including progressively impaired oogenesis and cancer. We are now seeking to understand the mechanistic basis of these phenotypes in kdm2aa and other chromatin regulator mutants.

We hope to recruit an enthusiastic and creative colleague who is interested in combining high-throughput sequencing approaches with mechanistic in vivo work exploiting our extensive zebrafish mutant collection. Experience in cloning, molecular biology, Illumina sequencing and zebrafish model systems would be ideal.

Our lab (www.buschlab.org) is in the Department of Medicine (https://www.citiid.cam.ac.uk/) and located on the Cambridge Biomedical Campus (https://cambridge-biomedical.com/).

For informal inquiries please contact Dr Elisabeth Busch-Nentwich (emb81@cam.ac.uk).

Fixed-term: The funds for this post are available for 1 year in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

http://www.jobs.cam.ac.uk/job/22839/

Closing date: 15th September 2019

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