Blog from August, 2019

Supplemental Questions

Required fields are indicated with an asterisk (*).

Applicant Documents

Required Documents

1. Cover Letter/Letter of Application
2. Transcripts
3. Curriculum Vitae
4. References
5. Teaching Philosophy
6. Statement of Research Interest
7. Diversity Statement

Optional Documents

1. Other

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Department of Immunology, Genetics and Pathology at Uppsala University (www.igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 400 million, out of which more than half is made up of external funding. The staff amounts to approximately 340 employees, out of which 100 are PhD-students, and there are in total more than 600 affiliated people.

Project description:
Genome-wide association studies (GWAS) have identified 100s of genetic loci that are robustly associated with the risk of diabetes. With few exceptions, the causal genes in these loci are currently uncharacterised.
Before results from GWAS can be translated into the clinic - for example as novel biomarkers or drug targets - we need to identify and characterise the causal genes in these loci. Recent developments in CRISPR-Cas9-based mutagenesis, high-throughput imaging, and image-based analyses have highlighted the zebrafish as a promising model system for systematic, large-scale genetic screens.
The overall aim of the proposed project is to identify and characterise causal genes in GWAS-identified loci for diabetes using zebrafish model systems.

Work description:
The position is funded by an international collaborative grant that aims to characterise diabetes candidate genes using human beta-cells (Oxford), drosophila (Stanford) and zebrafish (Uppsala). The zebrafish arm of the project includes: 1) generating and maintaining mutant lines using a multiplexed approach, i.e. studying the effect of multiple genes simultaneously; 2) imaging diabetes-related traits using an automated positioning system and fluorescence microscope; 3) preparing samples for downstream analyses and paired-end sequencing; 4) objectively quantifying image-based data; 5) quality control and analysis of sequencing results; 6) integrating multidisciplinary data and statistical analysis; 7) writing reports and presenting results to the consortium and at international meetings;  and 8) disseminating results in manuscripts for publication in peer-reviewed journals.

Qualifications:
Applications are accepted from highly motivated candidates with a PhD in Molecular Biology, Molecular Medicine, Molecular Epidemiology, or similar.
Applicants must have a documented and broad competence in basic molecular biology methodology and biostatistics. A successful candidate should be a highly motivated, organised, reliable team player that can also work independently and is proficient in communicating in English, both orally and in writing. Prior knowledge and experience in fluorescence microscopy, epidemiology, programming and/or image- based analyses are a bonus.

The application should include a cover letter describing yourself, your research interests and your experience relevant to this position; a CV/resume; a PhD certificate; a verified list of MSc course grades; a list of publications in peer-reviewed journals; and contact details for at least two reference persons. If available, letters of recommendation can also be included.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: Individual salary.

Starting date: As soon as possible.

Type of employment: Temporary employment of two years.

Scope of employment: 100 %

For more information contact:
Marcel den Hoed: marcel.den_hoed@igp.uu.se, +46(0)70-425 0752

Please submit your application by 15 September 2019, UFV-PA 2019/2692 using the following link:

https://www.uu.se/en/about-uu/join-us/details/?positionId=282728

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.

Placement: Department of Public Health and Caring Sciences

Type of employment: Full time , Temporary position longer than 6 months

Pay: Individual salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben seko@uadm.uu.se 
ST/TCO tco@fackorg.uu.se 
Saco-rådet saco@uadm.uu.se 

Number of reference: UFV-PA 2019/2692

Last application date: 2019-09-16

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Department of Immunology, Genetics and Pathology at Uppsala University (www.igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 400 million, out of which more than half is made up of external funding. The staff amounts to approximately 340 employees, out of which 100 are PhD-students, and there are in total more than 600 affiliated people.

Project description:
Genome-wide association studies (GWAS) have identified 100s of genetic loci that are robustly associated with the risk of diabetes. With few exceptions, the causal genes in these loci are currently uncharacterised.
Before results from GWAS can be translated into the clinic - for example as novel biomarkers or drug targets - we need to identify and characterise the causal genes in these loci. Recent developments in CRISPR-Cas9-based mutagenesis, high-throughput imaging, and image-based analyses have highlighted the zebrafish as a promising model system for systematic, large-scale genetic screens.
The overall aim of the proposed project is to identify and characterise causal genes in GWAS-identified loci for diabetes using zebrafish model systems.

Work description:
The position is funded by an international collaborative grant that aims to characterise diabetes candidate genes using human beta-cells (Oxford), drosophila (Stanford) and zebrafish (Uppsala). The zebrafish arm of the project includes: 1) generating and maintaining mutant lines using a multiplexed approach, i.e. studying the effect of multiple genes simultaneously; 2) imaging diabetes-related traits using an automated positioning system and fluorescence microscope; 3) preparing samples for downstream analyses and paired-end sequencing; 4) objectively quantifying image-based data; 5) quality control and analysis of sequencing results; 6) integrating multidisciplinary data and statistical analysis; 7) writing reports and presenting results to the consortium and at international meetings;  and 8) disseminating results in manuscripts for publication in peer-reviewed journals.

Qualifications:
Applications are accepted from highly motivated candidates with a PhD in Molecular Biology, Molecular Epidemiology, or similar. It must have been completed within three years of the application deadline. If you received your PhD earlier but special circumstances apply (i.e. prolonged periods of illness, parental leave, military service, union duties and others of similar character) then you may also be eligible to apply.
Applicants must have a documented and broad competence in basic molecular biology methodology and biostatistics. A successful candidate should be a highly motivated, organised, reliable team player that can also work independently and is proficient in communicating in English, both orally and in writing. Prior knowledge and experience in fluorescence microscopy, epidemiology, programming and/or image- based analyses are a bonus.

The application should include a cover letter describing yourself, your research interests and your experience relevant to this position; a CV/resume; a PhD certificate; a verified list of MSc course grades; a list of publications in peer-reviewed journals; and contact details for at least two reference persons. If available, letters of recommendation can also be included.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: Individual salary.

Starting date: as soon as possible

Type of employment: general temporary employment of two years

Scope of employment: 100 %

For more information Contact:
Marcel den Hoed: marcel.den_hoed@igp.uu.se, 070-425 0752

Please submit your application by 16 september 2019, UFV-PA 2019/2687 using the following link:

https://www.uu.se/en/about-uu/join-us/details/?positionId=282729

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.

Placement: Department of Immunology, Genetics and Pathology

Type of employment: Full time , Temporary position longer than 6 months

Pay: Individual salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: Seko Universitetsklubben seko@uadm.uu.se 
ST/TCO tco@fackorg.uu.se 
Saco-rådet saco@uadm.uu.se 

Number of reference: UFV-PA 2019/2687

Last application date: 2019-09-16

Contact: marie-catherine.vozenin@chuv.ch

Job Summary

Responsible for day-to-day operations of a multiuser, Zebrafish facility, as well as long-term maintenance and management in cooperation with the principal users (50%)

and

Responsible of research experiments on zebrafish embryo for the radio-oncology laboratory (50%).

Context:

The zebrafish facility consists of around 200 tanks and a doubling of the capacity for the zebrafish facility is planned within the next 18 months. The primary tasks in the position are animal care and husbandry, equipment and water testing and technical support. Monitoring the health of the animals and record-keeping are important duties of this position. Animals are checked daily for findings of behavior, illness or injury and the information is recorded and reported as necessary. The ability to perform accurate identification and census counts of animals is another important aspect of this position. In addition to zebra fish experience, the incumbent should have laboratory animal experience and all the required regulatory certificates. Some holiday and weekend coverage will be required.

Animal care and husbandry:

• Feeding (regime according to size and age)
• Animal health monitoring
• Breeding and stock maintenance

• Track and compile nursery viability rates
• Document and Log new stocks from the nursery

Equipment and water testing:

• Daily and weekly checks of water parameters
• Maintenance tasks of the water treatment system
• Cleaning and washing tanks and other equipment
• Collaborating and coordinating water treatment system preventative maintenance with building & engineering.

• Prepares laboratory reagents, chemicals, instruments, and equipment
• Perform routine and non-routine facility maintenance

Responsibilities in support and communication:

• Coordination of regulatory and compliance activities
• Assist Facility users with routine Facility operations and occasional experiments
• Assisting the researchers on request with different tasks (setting up breeding, isolating and incubating embryos, fin clipping etc.)
• Creation and maintenance of SOPs, manuals, and novel techniques.
• Direct work of students and temporary staff
• Emergency availability: Occasional after-hours emergency availability to respond to health and environmental situations as they arise
• Record data, summarizes, and analyzes results using basic statistics
• Oversite to facility access, training of facility users
• Timely communication (facility orientations/training, meetings, e-mails) with researchers about their animals and experiments
• Maintains supplies inventory in accordance with facility procedures. Ordering of supplies and other administrative tasks

Contribution to Research experiments:

• Production of embryo (wt and Tg)
• Genotyping
• Irradiation
• Microscopy
• Culture of zebrafish cells
• Development of tumor models in zebrafish

Required Qualifications

• CFC animal care or bachelor degree or equivalent level of related research animal experience
• Able to function independently and show initiative in keeping up-to-date on the latest developments in Zebrafish husbandry.
• Strong skills in data management and organization
• Two years of experience in providing direct care to aquatic species in a laboratory or equivalent environment.

Desired Qualifications

• Experience in direct management of an aquatics facility in a laboratory setting
• Specialized training in aquaculture
• Able to work well with multiple Facility users with varying levels of expertise, including students, fellows, faculty, and staff.
• Experience with software used for data management, such as Microsoft Excel or other database software
• Minimum two years of experience as an animal technician; to include experience in a zebrafish core facility, and supporting a variety of research interests: feeding hatchlings, juvenile and adult fish, setting-up matings, collecting eggs, baby nursery and cleaning of aquaria as well as other equipment used for the housing of laboratory animals
• Expertise with genome editing using CRISPR/Cas9, and in single cell microinjections to create transgenic zebrafish lines is preferred
• Certification by the Lemanic Animal Facility Network level I and II (RESAL). Working knowledge of the Animal Welfare Act and Regulations, the Guide for the Care and Use of Laboratory Animals, and the RESAL Policy.

Work Schedule

Monday – Friday 40hrs/ some weekends/holidays

Our laboratory studies the relationship between chromatin regulation, transcriptional changes and phenotypic outcomes using the zebrafish. We have shown that loss of the chromatin modifier kdm2aa causes multiple defects, including progressively impaired oogenesis and cancer. We are now seeking to understand the mechanistic basis of these phenotypes in kdm2aa and other chromatin regulator mutants.

We hope to recruit an enthusiastic and creative colleague who is interested in combining high-throughput sequencing approaches with mechanistic in vivo work exploiting our extensive zebrafish mutant collection. Experience in cloning, molecular biology, Illumina sequencing and zebrafish model systems would be ideal.

Our lab (www.buschlab.org) is in the Department of Medicine (https://www.citiid.cam.ac.uk/) and located on the Cambridge Biomedical Campus (https://cambridge-biomedical.com/).

For informal inquiries please contact Dr Elisabeth Busch-Nentwich (emb81@cam.ac.uk).

Fixed-term: The funds for this post are available for 1 year in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

http://www.jobs.cam.ac.uk/job/22839/

Closing date: 15th September 2019

A postdoctoral fellowship/senior research associate position is currently available in the Mchaourab lab at Vanderbilt University in Nashville, TN. The project entails the use of zebrafish as an experimental model to understand the proteostasis network in the lens and heart. We apply advanced genetic approaches, including transgenesis and genome editing (such as CRISPR/Cas9), and microscopic imaging techniques to decipher the functional roles of small heat shock proteins for the maintenance of transparency during lens aging as well as stress resistance of the heart. Our recent discovery revealed a direct coupling between proteostasis and cortisol stress signaling and future directions will seek to investigate the mechanistic bases of this coupling.

We are a highly interdisciplinary group with interest ranging from chaperones to multidrug transporters. The laboratory is located in the department of Molecular Physiology and Biophysics with access to state of the art cores in fluorescence microscopy, mass spectrometry and various biophysical instrumentation. The position will provide opportunities for applying mechanistic biochemistry in vitro to complement the in vivo genetic analysis as well as learning advanced biophysical techniques. 

Candidates should have a Ph.D. in biochemistry, cell biology, genetics, or related fields. The ideal candidate will have expertise in microscopy, image analysis, and modern molecular biology techniques along with experience in zebrafish rearing and husbandry.

If you are interested send CV to : Hassane S. Mchaourab, Ph. D., hassane.mchaourab@vanderbilt.edu

Postdoctoral Research Associate Position - Interneuron specification in the zebrafish spinal cord

Department of Biology, Syracuse University, New York.

Applications are invited for a postdoctoral research fellowship to work in the Lewis Lab

(http://lewislab.syr.edu/) examining how transcription factors specify the unique characteristics of

spinal cord interneurons.

The ideal candidate will be an experienced Developmental Biologist or Biochemist, preferably with

experience of working with zebrafish.

Experience in any of the following techniques would be an advantage: zebrafish embryology, in situ

hybridization, immunohistochemistry, Biochemistry, live cell imaging using multiphoton/confocal

microscopy, molecular biology, Co-IPs, constructing and analysing transgenic lines, FAC sorting and

microarray analysis and/or bioinformatic analyses of RNA-Seq or Chip-Seq data.

All candidates should have, or be about to obtain, a PhD in a relevant field.

Applicants should fill in the job application at http://www.sujobopps.com/postings/81071

job id 074691 and include a cover letter stating why they are interested in the position, a full CV with

bibliography and the names, addresses and email addresses of at least three referees.

Informal enquiries can be addressed to kelewi02@syr.edu.

Applications may be read as they are received. Closing date: 30th August 2019.

Only short-listed applicants will be contacted.

The SU Biology department (biology.syr.edu) is a vibrant department with strengths in Developmental

Biology, Genetics, Epigenetics, Neuroscience, Ecology and Evolution. Additional Neuroscience

faculty are also located in other SU dpts (neuroscience.syr.edu/Faculty.html).

Syracuse is an inexpensive and very pleasant and vibrant city to live in. It offers the amenities of a city

without lots of the hastles. It has its own airport (15 minute drive from downtown) and is close to

Toronto, New York City, Philadelphia, Montreal as well as the natural beauty of Upstate New York

(Niagara Falls, The Finger Lakes, Adirondack lakes and mountains etc).

Syracuse University also shares a campus with SUNY Upstate Medical University that has active

research programs in Cell Biology, Developmental Biology and Neuroscience and the Lewis Lab

regularly participates in seminar series and other programs with SUNY UMU researchers.

http://www.upstate.edu/research/research-departments.php

Postdoctoral Training Program in Developmental Biology and Regenerative Medicine - University of Colorado Anschutz Medical Campus

The Section of Developmental Biology at the University of Colorado School of Medicine, with support from the Gates Frontiers Fund, is inviting applications for our Postdoctoral Training Program. Member labs in the program use diverse model systems to address a broad range of questions in the areas of Developmental Biology, Disease Modeling and Regenerative Medicine:

Bruce Appel, PhD, Professor and Diane G. Wallach Chair of Pediatric Stem Cell Biology; website: https://www.appellab.com

We investigate genetic, cellular and molecular mechanisms of neural development using zebrafish as a model system. In particular, we investigate how neural progenitor cells are specified for neuronal and glial cell fates and mechanisms that regulate myelin plasticity in response to brain activity. 

• Ravanelli AM, and Appel, B. Genes & Development 29:2504-2515. PMCID: PMC4691953.
• Hughes, A. N. and Appel, B. bioRxiv 410969; doi: https://doi.org/10.1101/410969. Nature Communications (in press)

Emily Bates, PhD, Assistant Professor

The Bates lab uses human, mouse, and fly genetics to understand how cells coordinate to develop into complex structures like the human brain and face or a fly wing. Specifically, we are trying to understand how ion channels contribute to developmental signaling and how the cytoskeleton is regulated to build a brain.

• Dahal, GR, S. Pradhan, EA Bates. Development 2017 144:2771-2783. Doi:10.1242/dev146647. PMID: 28684627
• Belus, Matthew, Madison Rogers, Alladdin Elzubier, Josey, Megan, Rose, Steven, Bates, EA. Developmental BiologyDOI:10.1016/j.ydbio. PMID: 29571612
• Aiken, Jayne, Moore, J, Bates, EA. Human Molecular Genetics2018 doi:10.1093/hmg/ddy416. PMID: 30517687

Alexa Burger, PhD, Research Associate Professor

We use the zebrafish as our main model to understand the causes of congenital diseases affecting mesodermal organs. Our work combines gene-regulatory element discovery, genotype-phenotype association studies, and novel zebrafish-based models for pediatric diseases. We further develop new approaches for genome editing in zebrafish and beyond.

• D'Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A; Dis Model Mech. 2019 Jul 16;12(7). PMID: 31221659
• Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C. Development. 2016 Jun 1;143(11):2025-37. PMID: 27130213
• Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD. Nat Biotechnol. 2016 Jul 12;34(7):701-2. PMID: 27404876

Peter Dempsey, PhD, Associate Professor

The Dempsey lab studies the development and function of epithelial cells in gastrointestinal tract during normal physiology and disease. In particular, we are interested in how extracellular signals regulate intestinal homeostasis and the role of cellular plasticity during intestinal regeneration and in colitis-associated cancer. We use genetically engineered mouse models and both adult and iPS-derived intestinal stem cell enteroid cultures to study these events.

• Jones JC, Brindley CD, Elder NH, Myers MG Jr, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ. Cell Mol Gastroenterol Hepatol. 2019;7(3):533-554
• Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Mol Cell Biol. 2015 Nov;35(21):3604-21.
• Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC,Dempsey PJ. Gastroenterology. 2014 Oct;147(4):822-834.

Caleb Doll, PhD, Research Assistant Professor

We study developmental myelination in zebrafish larvae, with focus on the mechanisms underlying local production of proteins in nascent myelin sheaths. We use cell type specific methods to visualize and manipulate RNA binding proteins and associated mRNA targets during oligodendrocyte development.

• Doll, C, Yergert, K, Appel, B. bioRxiv; doi: 10.1101/669895
• Doll, C, Vita, D, Broadie, K. Current Biology 27, 1–13; 2017 Aug 7; https://doi.org/10.1016/j.cub.2017.06.046

Santos Franco, PhD, Assistant Professor and Boettcher Investigator; website: www.francolabcu.org

The Franco Lab uses mouse models to study several aspects of brain development. We are particularly interested in understanding early brain patterning, cell fate specification of neural stem cells, neuronal migration, dendrite formation and synaptogenesis. 

• Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ. (2018) J Neurosci. Jun 6;38(23):5237-5250. PMID: 29739868     
  • Fregoso SP, Dwyer BE, Franco SJ. (2019) Development. Mar 7;146(5). PMID: 30770393
  • Gutierrez MA, Dwyer BE, Franco SJ. (2019) eNeuro. May 7;6(2). PMID: 31073541

Christian Mosimann, PhD, Associate Professor and Johnson Endowed Chair in Heart Development Research

Our lab studies the mechanisms of cell fate determination during development and congenital disease, with particular focus on the origins of mesodermal cell types and of the cardiovascular system. We combine transgenic, genome editing, single-cell, and live-imaging approaches using the zebrafish as our principal model and engage in several cross-species collaborations.

• Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Panáková D, Mosimann C.; Nat Commun. 2018 May 21;9(1):2001. PMID: 29784942
• Cantù C, Felker A, Zimmerli D, et al.; Genes Dev. 2018 Nov 1;32(21-22):1443-1458. PMID: 30366904
• Prummel KD, Hess C, et al.; bioRxiv261115; doi: https://doi.org/10.1101/261115 (accepted/in print)

Charles Sagerström, PhD, Professor

Our group uses zebrafish to study transcriptional and epigenetic control of key transitions during embryogenesis. We are particularly interested in understanding the onset of zygotic gene expression at the maternal-to-zygotic transition and in the initiation of neural gene expression in the embryonic ectoderm.

• S.-K. Choe, F. Ladam and C. G. Sagerström. Developmental Cell 28:203-211. PMID:24480644
• F. Ladam, W. Stanney III, I. J. Donaldson, N. Bobola and C. G. Sagerström. eLife 2018;7:e36144. PMID: 29911973

Julie Siegenthaler, PhD, Associate Professor; website: www.siegenthalerlabcu.org

The Siegenthaler lab is focused on identifying cellular and molecular mechanisms regulating development and adult function of the CNS vasculature and the meninges. In pursuit of this goal, we utilize mouse genetics to specifically target meningeal and vascular cell populations and perturb signaling pathways of interest (retinoic acid, Wnt-beta-catenin), advanced imaging modalities, cell culture and transcriptional profiling. We have recently completed a first ever single cell transcriptome analysis of the developing meninges; this valuable tool will aid in studying the development of meningeal fibroblast populations and exploring interactions of fibroblasts with meninges-located vasculature and immune populations as well as the developing and adult CNS.   

• Bonney, S, Dennison, BJC, Wendlandt, M, Siegenthaler, JA. Frontiers in Cellular Neuroscience,
• Mishra, S, Kelly, KK, Rumian NL, Siegenthaler, JA. Stem Cell Reports.
• DeSisto, J, O’Rourke, R, Bonney, S, Jones, HE, Guimiot, F, Jones, KL, Siegenthaler, JA. bioRxiv. 

Kelly Sullivan, PhD, Assistant Professor and Boettcher Investigator

Our lab is interested in how an extra copy of chromosome 21 gives rise to the condition known as Down syndrome. We use a combination of primary samples, cell culture, and mouse models, to understand how aberrant interferon signaling affects development and contributes to pathophysiology in Down syndrome. 

• Sullivan KD*, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM*. Elife. PMID:27472900, PMCID: PMC5012864 *Co-corresponding Author   
• Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle, KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleo A, Blesa R, Fortea J, D’Alessandro A, Costello JC, Sullivan KD*, Espinosa JM*. Biorxiv 403642 *Co-corresponding Author   

The Training Program provides a mechanism for postdoctoral trainees to mature into successful independent researchers in Developmental Biology and Regenerative Medicine. Trainees are provided salary support in accordance with the NIH pay scale and the University of Colorado offers a full benefits package. Initial appointments will be made for one year with a second year of support contingent on satisfactory progress. The Program also provides each trainee with a mentoring committee, funds to attend conferences/courses and networking opportunities in the form of interactions with visiting scientists, national/international collaborations, journal clubs, research interest groups and annual retreats. Interested trainees will also be given opportunities to teach and mentor students as well as to improve writing skills.

Applicants must have a PhD degree and less than two years of postdoctoral experience as of September 1, 2019. Interested candidates should submit 1) a statement explaining their interest in the Program and indicating their preferred host lab (2-page maximum), 2) a CV and 3) arrange to have three reference letters sent. Review of applications will begin immediately and finalists will be invited for on-campus interviews. We anticipate filling four positions and interviews will continue until the positions are filled.

Questions and applications should be submitted by email to Dr. Charles Sagerström, Director of the Postdoctoral Training Program, at charles.sagerstrom@ucdenver.edu. This announcement can be accessed at: https://documentcloud.adobe.com/link/track?uri=urn%3Aaaid%3Ascds%3AUS%3Aa4fa1184-7562-49f0-a6f5-2a78592e0a1d