New Principal Investigator position in adult neurological diseases using zebra fish approaches at the CHUM Research Center – Department of Neuroscience, Faculty of Medicine, Université de Montréal
The Research Centre of CHUM (CRCHUM) in partnership with the Department of Neurosciences of the Université de Montréal (UdeM) is seeking applicants for a principal investigator position at the rank of assistant or associate research professor in the field of neuroscience and the specific use of zebrafish for the study of adult neurological disorders. The ideal candidate will be zebrafish neurobiologist with a strong expertise in transgenic, genetic and genetic regulation.
The new principal investigator will play a key role in complementing the research strengths of the CRCHUM especially in neurosciences. The mission of the CRCHUM-Neuroscience research axis is to elucidate the biological, environmental and social mechanisms of adult neurological diseases and to develop novel and innovative therapies to prevent, treat or cure them. The research activities incorporate clinical, basic and translational research and focus on neurodegeneration/neurorepair, neuroimmunology, neurovascular/stroke and epilepsy. The CRCHUM neuroscience research activities build on complementary and well-integrated teams and a vast array of cutting-edge approaches. Moreover, multiple research groups within the Faculty of Medicine and the larger Montreal research community offer numerous opportunities for collaboration. Montreal hosts one of the biggest neuroscience communities in North America. UdeM offers excellent training in neurosciences with undergraduate and graduate programs in neuroscience. This cosmopolitan city favors lively and culturally rich lifestyle.
Requirements
The applicant’s research program should address fundamental biological questions relevant to the physiopathology and treatment of adult neurological diseases, from the cellular/molecular to network levels, using zebrafish approaches. The candidate will have access to a large fish facility.
Applicants must hold a Ph.D. degree, with postdoctoral experience and a strong publication record in zebrafish neurosciences. Candidates will be expected to develop an innovative, internationally recognized, externally funded research program and contribute to teaching as well as to some administrative and academic activities at CRCHUM and UdeM.
Applications must be submitted electronically to
christine.bellefeuille.chum@ssss.gouv.qc.ca
Those received by October 1st 2019 will be given priority consideration, but the position will remain open until filled. A complete application will consist of a cover letter, a complete CV, a detailed research plan (3 pages limit) as well as three letters of support to be submitted separately by the referees, preferably in electronic format to:
Nathalie Arbour Ph.D.
Head Neuroscience Research Theme CRCHUM
Full Professor, Department of Neurosciences, Université de Montréal
Attention: Director of Human Resources, Mrs Christine Bellefeuille
About the CHUM Research Center
CHUM and its research center (CRCHUM) is one of the largest hospital-based research centres in North America. The CHUM Research Centre is a place of excellence where knowledge, expertise and innovation coexist, bringing tangible benefits to patients. More than 1800 employees including over 500 researchers and 400 students integrate the entire research continuum, including basic, clinical and population health research. For more information, please visit us at https://rachum.ca/crchum2018/en/
About Université de Montréal
The Université de Montréal is one of the leading research universities in Canada. Together, with its two affiliated schools, HEC Montréal and École Polytechnique, it constitutes one of the largest centres of higher education in North America. For more information, please visit the following link: www.umontreal.ca.
About Faculty of Medicine
An internationally renowned institution, the Faculty of Medicine has the threefold mission of education, research and the improvement of health in the areas of clinical sciences, basic sciences and health sciences. It has 16 departments, two schools and more than 700 professors (excluding clinical professors), serving more than 6000 students. A third of the physicians in Quebec and a large number of health professionals in the province have been trained at the Université de Montréal’s Faculty of Medicine.
* Language Policy
Université de Montréal is a Quebec university with an international reputation. French is the language of instruction. To renew its teaching faculty, the University is intensively recruiting the world’s best specialists. In accordance with the institution’s language policy, Université de Montréal provides support for newly-recruited faculty to attain proficiency in French.
Confidentiality
The Université de Montréal application process allows all regular professors in the Department to have access to all documents unless the applicant explicitly states in her or his cover letter that access to the application should be limited to the selection committee. This restriction on accessibility will be lifted if the applicant is invited for an interview.
Equal Access Employment Program
Through its Equal Access Employment Program, Université de Montréal invites women, aboriginal people, visible and ethnical minorities, as well as persons with disabilities to apply. During the recruitment process, our selection tools will be adapted to meet the needs of people with disabilities who request it. Be assured of the confidentiality of this information. The Université de Montréal is committed to the inclusion and the diversity of its staff and also encourages people of all sexual and gender identities to apply.
Immigration Requirements
We invite all qualified candidates to apply at UdeM. However, in accordance with immigration requirements in Canada, please note that priority will be given to Canadian citizens and permanent residents.
Die Eawag ist das international vernetzte Wasserforschungsinstitut des ETH-Bereichs (Eidgenössische Technische Hochschulen Schweiz). Sie betreibt Forschung, engagiert sich in der Ausbildung und ist im Bereich der fachspezifischen Beratung tätig. Damit verfolgt sie zwei parallele Ziele: den unmittelbaren menschlichen Bedarf an Wasser zu decken sowie die Funktionsfähigkeit und den Fortbestand aquatischer Ökosysteme zu erhalten.
Die Forschungsabteilungen Umwelttoxikologie und Aquatische Ökologie suchen eine/n
Technische/n MitarbeiterIn für die Hälterung und Zucht von aquatischen Organismen (100%)
Der Aufgabenbereich umfasst folgende Tätigkeiten:
- Selbstständige Durchführung, Planung und Überwachung der übertragenen Tierpflege (Hälterung und Zucht von Stammpopulationen von Fischen und aquatischen Invertebraten)
- Organisation und Management von Material und Anlagen zur Tierhaltung
- Überwachung und Weiterentwicklung unserer Experimentier-Anlage Aquatikum
- Unterstützung von im Aquatikum laufenden Forschungsprojekten
Für diese anspruchsvolle und interessante Aufgabe benötigen Sie eine abgeschlossene Ausbildung als Biologie-Laborant/in, Tierpfleger/in, oder eine vergleichbare Ausbildung und idealerweise Erfahrung in der Arbeit mit Wasserorganismen und entsprechenden Anlagen. Falls noch nicht vorhanden, haben Sie die Bereitschaft zur Ausbildung für versuchsdurchführende Personen entsprechend der Tierschutzausbildungs-verordnung (TSchAV 455.109.1) sowie zur Betreuung von Lernenden.
Im Rahmen dieser unbefristeten Vollzeitstelle erwartet Sie eine vielseitige und spannende Tätigkeit in nationalen und internationalen Forschungsprojekten, die Einsatzfreude, ein hohes Mass an Eigenverantwortung und Initiative, Flexibilität und Teamfähigkeit voraussetzt. Gute mündliche und schriftliche Deutsch- und Englischkenntnisse sind weitere wichtige Voraussetzungen für diese Tätigkeit.
Wir bieten einen modernen Arbeitsplatz in Dübendorf, fortschrittliche Anstellungsbedingungen, Weiterbildungsmöglichkeiten und ein vielfältiges Arbeitsspektrum. Die Eawag ist eine moderne Arbeitgeberin bei der die Mitarbeiterinnen und Mitarbeiter im Zentrum stehen. Wir fördern die Gleichstellung von Frauen und Männern und unterstützen arbeitende Familien. Mehr Informationen über die Eawag und ihre Anstellungsbedingungen finden Sie unter www.eawag.ch sowie http://www.eawag.ch/de/ueberuns/arbeiten/anstellung/.
Nähere Informationen über die Forschungsabteilungen Umwelttoxikologie und Aquatische Ökologie finden Sie unter https://www.eawag.ch/de/abteilung/utox/ und https://www.eawag.ch/de/abteilung/eco/.
Für Auskünfte zur Stelle steht Ihnen Frau Dr. Kirsten Klappert, E-Mail kirsten.klappert@eawag.ch gerne zur Verfügung.
Deadline für Bewerbungen ist der 16. August 2019 oder bis die Stelle besetzt werden konnte.
Wir freuen uns auf Ihre Bewerbung (mit Lebenslauf und Motivationsschreiben mit der detaillierten Beschreibung der relevanten Qualifikationen und Erfahrungen), welche wir ausschliesslich über unser Online-Bewerbungsportal erwarten.
Mit einem Klick auf den nachfolgenden Link gelangen Sie direkt zum Bewerbungsformular.
To view the job posting and/or apply for the job, click here:
Job Summary:
Supervisor, Animal Care & Health for Center for Comparative Medicine (CCM) aquatics and provides direction and guidance to husbandry staff and research support and performs all tasks necessary for the care and management of the on-site Zebrafish and Xenopus colonies. Assists Facility Manager/Director of Facility Operations in interviewing process, performance reviews, disciplinary actions, etc. Reviews & recommends changes to policy & procedures to ensure that CCM & investigator's staff adhere to all NU, local, state, &/or federal rules & regulations & that all actions are completed by strictly & consistently following applicable CCM SOPs including safety procedures & guidelines. Ensures accurate & timely creation & maintenance of all associated documents & records regarding training, environmental parameters, animal health monitoring, animal medical records, equipment maintenance, quality control, etc. Oversees & manages procurement & proper storage of husbandry supplies.
Working Conditions: Weekend, holiday and off hour monitoring of building management alarms is required. The ability to respond to and coordinate off hour emergencies and repairs may be necessary. Work stations are close to each other and work space is limited. Work may require extended hours sitting at a computer terminal. Regular travel between the Chicago and Evanston campus may be required. Must be enrolled in the university’s occupational health program which entails filling out a health questionnaire. The health questionnaire is submitted to the university’s occupational health provider for review. Must be willing to undergo job-related background check.
Specific Responsibilities:
Manages & oversees daily operations of aquatics equipment and tank washer facilities:
- Ensures on-going compliance with all NU, local, state, & federal rules & regulations.
- Ensures SOP compliance by all CCM employees & investigator staff & immediately reports deviations to management.
- Ensures that all equipment is operational & schedules on-going maintenance & repairs. Provides maintenance on rack pumps, filter systems, dispenser systems, washers, RO water operations, etc. Performs troubleshooting as needed.
- Ensures that necessary supplies are purchased as efficiently as possible & available as appropriate in a timely fashion.
Manages & oversees daily operations of aquatics husbandry activities:
- Ensures on-going compliance with all NU, local, state, & federal rules & regulations.
- Ensures SOP compliance by all CCM employees & investigator staff & immediately reports deviations to management.
- Ensures animal health checks are conducted in a timely & accurate manner and that housing densities are appropriate.
- Ensures that all husbandry records & documents are accurately updated & maintained in a timely manner.
- Schedules husbandry staff including rotating shifts, vacations & holidays ensuring that all activities & facilities are staffed adequately & appropriately.
- Manage monthly census and weekly space availability.
- Ensure water quality monitored and tested at appropriate frequencies (temperature, pH, conductivity, dissolved oxygen, etc.).
- Oversees inventory control process & storage of husbandry supplies, restocks supplies as needed, apply knowledge regarding methods of food preservation, rotation & or conservation.
- Directs sanitation of primary (tanks and accessories) & secondary housing (rooms) of animals, as well as support areas as required.
- Manages feeding and preparation of artemia.
- Prepares for departmental, IACUC, AAALAC & USDA facility inspections ensuring that facilities, processes, procedures, documentation, etc. are in order.
Manages animal health care, research support and incoming animal activities:
- Ensures on-going compliance with all NU, local, state, & Federal rules & regulations.
- Ensures SOP compliance by all CCM employees & investigator staff & immediately reports deviations to management.
- Ensures that all animal medical records & documents are accurately updated & maintained in a timely manner.
- Ensures daily animal health observations are performed under direction of Veterinarian. Perform minor animal treatments as prescribed by the Veterinarian and maintain appropriate record keeping. Perform euthanasia as needed.
- Ensure “sentinel” testing performed at appropriate intervals to manage colony health.
- Provide timed and regular egg collections to support research and ensure future mating generations. Follow egg washing procedures.
- Performs animal handling, sexing, genotyping, measurements and other research activities as needed.
- Ensure staff document and complete tasks related to incoming animals. Staff prepares and schedules for incoming animals and interacts with procurement, receiving & census as appropriate.
Assist Facility/Husbandry Managers:
- Interviews & recommends new hires.
- Manages annual performance evaluation process ensuring that all husbandry staff receives reviews & that documentation regarding performance is properly maintained in a timely manner.
- Manages staff & ensures overall supervision; ensures that inappropriate & problem behavior is identified in a timely manner & that corrective actions are implemented as needed.
- Ensures that all physical plant buildings, areas, equipment, etc. are maintained in accordance with all pertinent regulations, policies, codes, etc.; coordinates repairs, upgrades, regular & special maintenance, etc.
- Supports the collection of physical plant data required for the AAALAC Program Description.
- Develops & implements CCM OJT programs and SOPs that ensure proper animal care & welfare. Participates in CCM, NU, local & or national meetings, management classes, OJTs, etc.
- Performs other duties as assigned
Minimum Qualifications:
- A high school diploma or its equivalent is required along with a minimum of 5 years animal husbandry or equivalent experience (with AALAS certified LATg) or 4 years' experience with AA AS BS. One year of supervisory experience is required.
- A minimum of 5 years’ experience with aquatics systems and working with zebra fish.
- AALAS certified LATg
- Valid state driver's license if driving animal transport van.
Preferred Qualifications:
- Greater than 5 years of working with aquatics systems, zebra fish and supporting zebrafish research.
- College education
- Experience managing multiple persons of diverse backgrounds
- CMAR certification (preferred)
Duties/ Responsibilities:
Under direction of Aquatic Facility Manager, this position is responsible for the daily care and husbandry of zebrafish in a research environment in accordance with all applicable laws and regulatory guidelines. Technician will maintain health and well-being of laboratory zebrafish by providing a stable, sanitized environment with quality food and water and husbandry practices. Specific responsibilities include; perform and record daily animal health observations, communicate any adverse findings to the manager, and complete required documentation. Technician will maintain clean, orderly and sanitized work areas - identifying any problems and notifying aquatics facility manager, perform daily room checks for environmental conditions (temperature, salinity, lighting, pH), perform and record all water chemistry testing, and complete required area documentation. This position will operate equipment including glass washer, pure water salt dosatron, and integrated electronic water quality monitoring systems; observing standard operating procedures and safety guidelines. Technician will monitor equipment for proper operation and complete appropriate documentation. Additionally, technician will oversee invertebrate cultures for feeding larval fish, monitor supplies and communicate supply needs to manager in timely manner. Under supervision, technician may assist in fish facility/room training. Some holiday and weekend coverage will be required. This is a grant funded position, and ongoing support for it is contingent on funding.
Basic Qualifications:
AALAS Assistant Laboratory Animal Technician (ALAT) certification within six months of hire AND at least six months experience in animal care or equivalent.
Additional Qualifications:
BA/BS or College background in Biology is strongly preferred as is one year of animal (ideally zebrafish) care/husbandry work experience. The job responsibilities require the analytical skills to gather and interpret data in situations in which the information or problems are relatively routine. The successful candidate must be a highly motivated, responsible individual with strong organizational skills.
Additional Information:
This is a two year position with the possibility of extension based on satisfactory performance and the availability of continued funding.
A two year (extendable) fully funded (minimum NIH scale) postdoctoral position (junior or senior) is available in the Gibert Lab in the Department of Cell and Molecular Biology and Cancer Center and Research Institute at the University of Mississippi Medical Center (UMMC) in Jackson Mississippi (https://www.umc.edu/som/Departments%20and%20Offices/SOM%20Departments/Cell%20and%20Molecular%20Biology/For%20Faculty/Yann%20Gibert.html). The Gibert Lab takes advantage of the zebrafish to model multiple human genetic diseases (CRISPR/cas9).
Current areas of interests include: obesity, diabetes, metabolic disorders, endocrine disrupters and cancer
Our efforts are supported by a recently awarded discovery project (RO1 equivalent) from the National Health and Medical Research council (NHMRC Australia, NIH equivalent) and a generous start up package form UMMC
REQUIRED QUALIFICATIONS:
PhD degree required. Applicants must be highly motivated and technically accomplished as documented by exceptional publication record. Candidates must have demonstrated experience in molecular biology and CRISPR/cas9 technology. Experience with zebrafish embryogenesis in mandatory.
UMMC has a large campus with multiple schools (graduate, medical, dental, allied-health, nursing, etc.). Our lab is well-equipped, with strong core facilities available. We have a state-of-the art Techniplast aquatic with dedicated personals to look after the fish and embryos so you can focus on experiments.
Jackson is located in the heart of the south with the most welcoming people in the country and plenty of outdoor activities available and low cost of living
TO APPLY:
Please email CV and reprints of relevant publications to the contact information below. Applicants accepted for initial consideration will be subsequently contacted for letters of reference.
Expected starting date: fall 219
Yann Gibert, PhD
Associate Professor
Department of Cell and Molecular Biology and Cancer Institute
University of Mississippi Medical Center
Jackson, MS
e-mail: ygibert@umc.edu
“Single-Cell RNA-seq Analysis and Data Visualization”
Full Time, 1 year, renewable to 2 years
Salary: According to experience
Closing Date: 31st of July 2019
Starting Date: November 2019
A postdoctoral position is open in the “Development of Mucosal Immunity and Tissue Integrity Lab” headed by Pedro Hernandez, which will be opening on September 2019 at the Genetics and Developmental Biology Department of Institut Curie in Paris, France.
Transciptomic analysis at the single-cell level has revolutionized our understanding of the existence and behavior of cell type diversity during development as well as of the different states of the immune system, enabling the discovery of novel potential therapeutic targets for several pathological disorders. Our team focuses on identifying and studying mechanisms regulating mucosal innate immune responses and epithelial integrity making use of the zebrafish model. The zebrafish offers significant experimental advantages including high fecundity, external development, easy genetic manipulation, small size and transparency. We are combining these advantages with single-cell transcriptomic profiling to study mechanisms regulating the diversity, plasticity and function of different cell lineages during innate immune responses.
We are looking for a candidate with proficiency and documented laboratory research experience, particularly in bioinformatics analysis. The candidate will lead single cell genomics pipelines and will be responsible for the development, enhancement and maintenance of the scRNAseq program of the lab.
Specific requirements
Solid skills and experience in bioinformatics with proven track record in handling NGS datasets and developing analysis pipelines for single cell analysis
Good knowledge in biostatistics and experience in programming (R, perl, C or python)
Highly motivated researcher with interest in developmental biology and/or immunology
Ability to work independently
Fluency in both spoken and written English
Wet lab experience on library preparation will be an advantage but is not mandatory
Experience or motivation to learn biological experimentation utilizing the zebrafish would be a plus
The candidate will benefit from the top-level scientific environment of Institut Curie, and of state-of-the-art technological platforms, including a Bioinformatics Department. The lab is located in the Curie campus in the heart of Paris providing interdisciplinary expertise and a very friendly and international environment.
Application
Please send: CV including publications, a statement of interest, and the names and email addresses of 2-3 potential referees to pedrohernandezlab@gmail.com indicating “LASTNAME_Postdoc application” in the subject. For further queries: phernand@pasteur.fr