A postdoctoral position is available at the University of California, San Francisco to study the role of neuromodulatory transmitter dopamine in regulating brain-wide plasticity and motor behaviour in the context of parkinson’s disease. The lab, https://pharm.ucsf.edu/guo, composed of four postdoctoral fellows, three graduate students, and two technical staffs, is a productive and nurturing environment for training and career development. This project employs molecular genetic models in the transparent larval zebrafish and utilizes brain-wide calcium imaging and large-scale data analysis. The applicant should have a recent PhD or PhD/MD degree, be familiar with 2-photon/confocal/light-sheet microscopy and computational coding, and has high quality publication(s) in peer-reviewed journals. To apply, please send your CV, a brief research statement, together with the contact info of three referees, to: su.guo@ucsf.edu.
The Fishman Laboratory in the Department of Stem Cell and Regenerative Biology at Harvard University is looking for an enthusiastic and highly experienced Research Assistant IV with an interest in developmental biology, genetics, and social behaviors. The Fishman Lab is interested in dissecting complex social behavior by using zebrafish as a model system.
The candidate will work closely with scientists in the lab reporting results to supervisor or other lab personnel. The candidate will assume a high level of responsibility for independent judgment concerning future experiments depending upon results.
Full details and an online application portal are at: http://bit.ly/2YmbH6y
The Juntti Lab at the University of Maryland is seeking a postdoctoral fellow to work in an HFSP-funded position to understand the neural circuitry of visual perception in cichlid fish. We work in a multi-lab collaborative team to understand the differences in visual circuits in comparison with zebrafish. This project will determine the stimuli that evoke behavior, and will use genetically-encoded calcium indicators to identify the responsive neurons.
Our lab focuses on the control of social behavior, and we ultimately seek to link perception to behavior. We are a well-funded young lab using cutting-edge technologies in molecular genetics, neuroanatomy, pharmacology to make these links. We use the family of cichlid fish as our model system, as they exhibit complex social behaviors and are genetically tractable. We’re looking for a motivated candidate who will pursue independent research, working within a dynamic team of scientists.
Lab website: biology.umd.edu/scott-juntti
Desired qualifications
- Experience working with animal models, bonus for prior fish work
- Interest in mentoring undergraduate students
- Able to manage overlapping projects effectively
- Ability to work with general guidance
- Excellent organizational skills and demonstrated ability to accurately complete detailed work
About the environment
The University of Maryland is located in College Park, 6 miles from Washington, DC. It is easily accessible by Metro or car. We are housed in the Department of Biology, a stimulating group of scientists studying everything from ecology to evolution to neural circuits. UMD is a center of excellence for cichlid genetics as well, with the Carleton & Kocher labs located in the same building.
Compensation
Salary is commensurate with experience. UMD offers excellent benefits: https://uhr.umd.edu/benefits/
To apply: Please send a C.V. with names of three references and a cover letter to sjuntti@umd.edu briefly addressing the following questions: How do see your skills, training, and previous experience fitting with the lab? How would this work fit with your future career goals?
We seek a manager for a multi-user zebrafish facility at the University of Colorado Anschutz Medical Campus. Applicants should have a minimum of three years-experience working in aquaculture, although relevant education can be substituted for experience on a year-to-year basis. Primary responsibilities include training of facility users, equipment maintenance, husbandry tasks such as in vitro fertilization and cryopreservation, and management of care staff. Full details and an online application portal are at https://cu.taleo.net/careersection/jobdetail.ftl?job=16193
Questions can be directed to Dr. Bruce Appel, bruce.appel@ucdenver.edu
| ECOLE NORMALE SUPERIEURE Laboratoire de Physique et Institut de Biologie associé au CNRS et aux Universités Paris VI et VII 46 rue d’Ulm, Paris 75005 |
Post-doctoral position available at ENS
A 2-3 years post-doctoral position is available at the ENS, Paris, to study the initiation and growth of cancer from a single cell in zebrafish. The idea is to use the optogenetic tools developed in the host lab to turn on one (or a few) oncogenes (or off some tumor suppressor genes) in single cells of a zebrafish larvea. The probability of tumorigenesis will be measured and the genetic analysis of cancer developing cells vs non-cancer developing ones will be conducted.
For this project we are looking for a smart, independent and driven person with demonstrated experience in zebrafish: micro-injection, transgenesis, microscopic observations, ISH and genetic analyses.
Knowledge of image analysis (ImageJ) and computer programming (R, Matlab, LabView) favored.
The person will be paid a net post-doctoral salary of about 2800€ (depending on experience).
Appropriate candidates should send their CV and three letters of recommendation to David Bensimon (david@lps.ens.fr) .
References:
- “Optical control of tumor induction in the zebrafish”, Z.Feng, S.Nam, F.Hamouri, I. Aujard, B.Ducos, S.Vriz, M.Volovitch, L.Jullien, S.Lin, S. Weiss and D.Bensimon, Sci.Rep. 7, 9195 (2017)
- “Control of protein activity and gene expression by cyclofen-OH uncaging”, W.Zhang, F.Hamouri, Z.Feng, I. Aujard, B. Ducos, S. Ye, S.Weiss, M.Volovitch, S.Vriz, L.Jullien and D.Bensimon, ChemBioChem 19,1-8 (2018)
Join the HJF Team!
The Center for the Study of Traumatic Stress at the Department of Psychiatry, Uniformed Services University (USU), is seeking a Postdoctoral Fellow. HJF provides scientific, technical and programmatic support services to USU in Bethesda, Maryland. The laboratory is interested in using and developing zebrafish behavioral screening assays to investigate candidate therapeutic agents for the treatment of PTSD. The Postdoctoral Fellow will be responsible for initiating and conducting experiments with zebrafish in collaboration with a multidisciplinary project team. This position requires US Citizenship.
The initial appointment for this position is for one year, with the possibility of renewal for a second year.
Responsibilities:
- Assists in designing, developing, executing, and implementing scientific research and/or development.
- Investigates the feasibility of applying a wide variety of scientific principles and theories to potential inventions and products.
- Performs specialized laboratory research utilizing experimental protocols which will involve specialized procedures such as exposure of zebrafish larvae to a stimulus, measurement of response using behavioral recording equipment and software, testing of medicinal compounds for ability to modify response to stimuli..
- Collects and handles samples and keeps detailed records of experiments.
- Participates in planning and conducting analyses of data from zebrafish experiments.
- Assists with the preparation of data for presentations at scientific meetings and for publication in journals.
- Assists with training laboratory staff as needed.
- Maintains cleanliness of laboratory areas.
- Performs other duties as assigned.
Required Knowledge, Skills, and Abilities: Knowledge of appropriate scientific area (pharmacology, neuroscience, physiology, molecular biology, etc.); ability to analyze and interpret data. Prior experience in zebrafish biology and/or behavioral studies in animal models is preferred.
Minimum Education/Training Requirements: PhD in a related scientific discipline
Minimum Experience: 0-2 years
Physical Capabilities: Long periods of standing and sitting; intricate work with hands; carrying of light and moderately heavy laboratory equipment
Supervisory Responsibilities/Controls: May provide guidance to laboratory staff
Work Environment: Laboratory environment; may involve working with biohazardous materials; may require working evenings and weekends
Background: US Citizenship required. Candidates must be able to obtain a Common Access Card (CAC) clearance.
HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.
Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Director of Human Resources.
To apply to this position, please click here.
PhD Project - Nanomedicine & Molecular Biology Lab, Univesity of Pisa
Project Title: Nanotransducers in gene therapy
Supervisor: Vittoria Raffa
Application deadline: 29th May 2019
Project description: The most significant genetic tool of the 21st century concerns targeted genome editing using engineered nucleases. Among these, the most commonly used is CRISPR/Cas9 technology that, by means of an RNA guide (g-RNA), recognizes specific genomic sequences and induces double strand breaks (DSBs). Despite its therapeutic potential, CRISPR/Cas9 system is considered not yet mature for clinical applications, because of potential off-target activity, e.g. unspecific cuts of the genomes. In this scenario, nanomedicine will be used to give both temporal and spatial control over gene editing to switch off gene expression at specific times in specific tissues. This technology would bring: i) improvement of safety; ii) treatment of multi-genic diseases; iii) non-viral delivery of editing components. From a scientific and technological point of view, accomplishment of these objectives will pave the way for new horizons and opportunities in the treatment of solid cancer tumors through the achievement of unmatched safety level for the development of effective genome therapeutics.
Keywords: gene editing, nanoparticles, zebrafish model
NOTE: grant reserved to students who have graduated from foreign (non-Italian) universities
Call available on https://lnkd.in/dWuFx_i
http://dottorato.unipi.it/images/stories/competition2019_2020/concorsi_eng/bio05_engl.pdf
Research Positions, Mokalled Lab, Washington University School of Medicine in St. Louis.
The Mokalled lab in the Department of Developmental Biology at Washington University School of Medicine is seeking highly motivated scientists to join our vibrant and collaborative research team (http://www.mokalledlab.com/). We use zebrafish spinal cord regeneration as a discovery platform to study spinal cord regeneration across species. Candidates with expertise in zebrafish regeneration models or cell reprogramming models are encouraged to forward a cover letter, CV, and list of 2-3 references to mmokalled@wustl.edu.
An individual with expertise in zebrafish husbandry and development, and in maintaining the smooth running of a large Zebrafish Facility, will is needed to support NIH funded research. The successful candidate will be responsible for maintaining the health and vitality of the Tufts Zebrafish Facility, including Millipore and charcoal/particle filter changes, water quality monitoring, and maintaining all of the functions of the automated system including daily water changes, pH and salinity dosers and probes. He/she will conduct daily feeds and will maintain a variety of zebrafish lines relevant for study of human mineralized tissue diseases.
The Yelick Laboratory is located on the Tufts Medical Campus in Boston, and includes a 2,000 tank Tufts Zebrafish Facility located within the Yelick Lab. The successful candidate will have a recent B.A. and expertise in the zebrafish model. Expertise with single cell microinjections is also preferred. The successful candidate will be highly self-motivated, reliable, dependable and productive, have excellent communication and organizational skills, and work well and effectively with others. The selected individual will work with Postdoctoral Fellows, graduate and undergraduate students, and technicians on relevant projects.
Applicants should email CVs and full contact information for 3 references to:
Pamela C. Yelick, PhD
Tufts University, Boston MA
ERC-funded Postdoctoral Scientist fellowship
SIGNALING IN ANGIOGENESIS
Laboratory of Angiogenesis and Redox Metabolism
Dept. of Biology, University of Padua, Italy
The laboratory of Prof. Massimo Santoro, Department of Biology at the University of Padua,
Italy, is offering an ERC-funded post-doctoral position to study blood flow signaling during
angiogenesis. Blood flow and mechanical stress have not been fully decoded within
aspects of cellular signaling during blood vessel development. As such, our goal is to
understand how blood flow regulates vascular development and homeostasis using genetic
approaches along with advanced molecular and proteomic techniques. This project focuses
on using genetically encoded metabolic sensor, DNA editing knock-out/in techniques, and
in vivo angiogenesis models. The Santoro lab currently holds extensive experience in
biochemistry as well as the genetic, molecular, and cellular biology of endothelial and mural
cells in different vertebrate animal models and in human primary cells (1). The laboratory
contains zebrafish and mouse animal facility, advanced stereo/confocal/light sheet
microscopy equipment, advanced gene-editing techniques, and metabolic core facilities.
The candidate must be highly motivated, enthusiastic, and an efficient researcher with a
PhD in a relevant discipline. The applicant must be capable of working in a team as well as
independently. Excellent communication skills both spoken and written English are required.
We offer a dynamic work environment in a stimulating scientific surrounding with a young,
enthusiastic, motivated team along the opportunity to contribute to high-impact projects. We
offer a strong competitive salary as well as contributions to health and retirement funds.
Contact
Please send your CV, letter of motivation, and the contact information of at least two referees
to Prof. Santoro at massimo.santoro@unipd.it or visit https://massimosantorolab.com
(1) Chen et al., 2017, Cell Rep; Ramasamy et al., 2016, Nat. Commun.; Santoro, 2017, Semin
Cell Dev Biol.; Sinha and Santoro, 2018 Cardiovascular Research; Norris and Santoro,
ATVB, 2018.
A postdoctoral position to study molecular mechanisms of vascular development is available in the laboratory of Dr. Saulius Sumanas in the Division of Developmental Biology, at the Cincinnati Children's Hospital Medical Center.
The laboratory uses the zebrafish model to study molecular mechanisms of vascular development. We also use zebrafish to model human vascular diseases, including intracranial aneurysms and vascular malformations. Candidates with a strong background in developmental and molecular biology are invited to apply. Prior experience in zebrafish is helpful but not a requirement.
To apply, please send a CV and contact details of three referees to saulius.sumanas@cchmc.org
Website: http://www.cincinnatichildrens.org/research/divisions/d/dev-biology/labs/sumanas/default/