The Stowers Institute for Medical Research has an opening for a full-time Laboratory Technician in the Aquatics Facility. Primary duties include: providing routine care and husbandry of multiple aquatic species including feeding, water exchanges, tank cleaning, and health monitoring; developing and modifying animal care policies, standard operating procedures (SOPs), and practices which promote high quality, cost effective operation of the facility; interacting with faculty, staff, and other teams to provide high quality, responsive animal care services; monitoring supply and equipment inventory to sustain day-to-day operations; maintaining accurate records including: room logs, health reports, animal census, and other records as required; and preparing for all regulatory inspections.
The successful candidate will be self-motivated, have excellent communication and organizational skills, and the ability to work closely with other team members. Prior experience with aquatic animals and a basic understanding of system maintenance relating to recirculating aquaculture systems is preferred.
Minimum requirements include a Bachelor’s degree in any of the life sciences (e.g., animal science, biology, microbiology, aquaculture). Basic computer skills and a working knowledge of computer programs such as Microsoft Outlook, Excel, and Word are required. In addition, the candidate will be required to become ALAT certified through AALAS. Weekend and Holiday work will be required.
Application Instructions: To apply, please submit a current resume and cover letter to careers@stowers.orgor to Administration Department, Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110.
Several Summer Undergraduate Student Fellowships for zebrafish research are available from Zscientific. See www.zebrafishfilm.org for application information.
A Postdoctoral Research Associate position is available in the Department of Neuroscience of the Albert Einstein College of Medicine (Bronx, New York). As in chemical synapses, electrical synapses represent true synaptic structures that undergo modifications of their synaptic strength. Plastic changes of electrical synapses play important functional roles by reconfiguring neural networks. We investigate these properties at identifiable mixed synapses on the larval zebrafish Mauthner cell, at which detailed molecular mechanisms are been investigated by combining powerful genetic manipulations with in-vivo imaging, electrophysiology and time-resolved ultrastructural analysis. The laboratory is focused on understanding 1) the molecular complexity of the structures underlying electrical synaptic communication (neuronal gap junctions) at these synapses, and 2) the ultimate molecular mechanisms that are responsible for changes of their synaptic strength. We are seeking for highly motivated individuals with strong background in cellular neurophysiology, imaging and/or the zebrafish model who are interested in joining our efforts.
The Department of Neuroscience (http://www.einstein.yu.edu/departments/neuroscience/) provides an excellent environment for scientific research, including exceptional core facilities in optical imaging, genomics, proteomics, optogenetics and behavior.
Applications, including a detailed CV, should be submitted to Dr. Alberto Pereda at alberto.pereda@einstein.yu.edu.
Relevant publications:
Cachope R., Mackie K., Triller A., O’Brien J. and Pereda A. Potentiation of electrical and glutamatergic synaptic transmission mediated by endocannabinoids. Neuron, 56, pp. 1034-1047, 2007.
Rash J.E., Curti S., Davidson K.G.V., Nannapaneni S., Palacios-Prado N., Flores C., Yasumura T., O'Brien J.,Bukauskas F., Nagy J.I. and Pereda A. Molecular and functional asymmetry at a vertebrate electrical synapse. Neuron, 79, pp. 957-969, 2013.
Pereda A. Electrical synapses and their interactions with chemical synapses. Nature Reviews Neuroscience,15, pp. 250-263, 2014.
Yao C., Davidson K., Delfiner M., Eddy V., Lucaci A., Soto-Riveros C., Yasumura T., Rash J.E. and Pereda A. Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse. Journal of Neurophysiology, 112, pp. 2102-2113, 2014.
Miller A. and Pereda A. The electrical synapse: Molecular complexities at the gap and beyond. Developmental Neurobiology, 77, pp. 562-574, 2017.
Alcamí P. and Pereda A. Beyond plasticity: the dynamic impact of electrical synapses on neural circuits. Nature Reviews Neuroscience, in press.
A postdoctoral opening is available immediately in the Yin laboratory at the Cincinnati Children’s Hospital Medical Center, Division of Gastroenterology, Hepatology and Nutrition. Our group collaborates with physicians in the Pediatric Liver Center and geneticists in the Division of Human Genetics to conduct translational research on childhood inherited cholestatic liver diseases. We use zebrafish and mouse models to study disease pathogenesis, discover causative variants, and develop novel therapeutic strategies. Projects utilize multidisciplinary approaches: genetics (next generation sequencing, transgenesis, and application of CRISPR/Cas9 genome editing to generate mutants), confocal imaging, chemical screen, bioinformatics, and liver pathophysiology. We also have the unique opportunity to validate experimental findings in patient liver samples.
Details about project areas can be found at:
http://www.cincinnatichildrens.org/research/divisions/g/gastroenterology/labs/yin/default/
Our recent publication:
Ellis JL, Bove KE, Schuetz EG, Leino D, Valencia CA, Schuetz JD, Miethke A, Yin C. Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology. 2018 Apr;67(4):1531-1545. doi: 10.1002/hep.29632. PubMed PMID: 29091294. (https://www.ncbi.nlm.nih.gov/pubmed/29091294)
We seek a highly motivated scientist who is independent, focused, productive, and possesses exceptional skills in cellular/molecular biology and an enthusiasm for learning and developing new techniques. Candidate must hold a recent doctorate in Cell/Developmental Biology, Genetics, or related field, and proficient in spoken and written English. Experiences with zebrafish and rodent models and background in hepatology are desirable, not essential.
Interested applicants should submit a cover letter detailing research experience and future interests, a Curriculum Vitae, and arrange for three letters of recommendation to be sent to:
Chunyue Yin, PhD
Cincinnati Children's Hospital Medical Center is an Affirmative Action/Equal Opportunity Institution. Women and Minorities are encouraged to apply.
A postdoctoral position is available IMMEDIATELY in the Laboratory of fish protistology at
the Institute of Parasitology, Biology Center of Czech Academy of Sciences for a duration
of 2.5 years and potential for prolongation thereafter.
The fellow will join an international research team studying host-pathogen interaction
resulting from the arms race between the myxozoans and the immune system of fish. The
principal aims of the project are the elucidation of mechanisms underlying the development
of specific immunity and the analysis of the evasion strategies employed by the parasite. Our
model is common carp and myxozoan parasite Sphaerospora molnari.
Candidates with a Ph.D. or equivalent, with previous experience with animal experimentation,
flow cytometry, immunological assays or cell biology techniques are encouraged to apply.
Preference will be given to candidates who attained their postgraduate degree within
the last 3 years.
The Institute of Parasitology is one of the largest European centers of parasitological research,
located in České Budějovice, the capital city of South Bohemia known for its original Budweiser
beer. The city is surrounded by the UNESCO heritage sites of Hluboká nad Vltavou and
Český Krumlov, and the pristine nature of Bohemian Forest National Park.
For more info send CV and cover letter to Dr. Tomáš Korytář tkorytar@paru.cas.cz
Postdoctoral position available in the Nicolson Lab, at Stanford University School of Medicine (OHNS Department).
We study the molecular basis of hearing and balance in zebrafish with a focus on the development and function of mechanosensory hair cells. We use both forward and reverse genetic approaches to isolate mutants with auditory/vestibular behavioral deficits; to date, the majority of the genes we’ve identified via forward screens are implicated in human deafness. We use a wide range of methods for our projects including molecular, behavioral, and imaging analyses. In addition, co-mentoring by Dr. Tony Ricci is possible to broaden the training experience with electrophysiological recording and imaging techniques.
Desired training/skills for the successful candidate:
Proficiency with the usual skills of working with zebrafish or a similar animal model (husbandry, transgenesis, CRISPR, in situ hybridization, immunohistochemistry, EM, etc.). Some experience with imaging and/or electrophysiology is a plus!
Please send a letter of interest, curriculum vitae, and the names of three references to tnicolso@stanford.edu.
Recent papers of interest:
Maeda, R., Pacentine, I., Erickson, T., and Nicolson, T. (2017) Functional analysis of the transmembrane and cytoplasmic domains of Pcdh15a in zebrafish hair cells. Journal of Neuroscience, 37: 3231-3245.
Erickson, T., Morgan, C., Olt, J., Hardy, K., Busch-Nentwich, E., Maeda, R., Clemens- Grisham, R.,
Krey, J., Nechiporuk, A., Barr-Gillespie, P., Marcotti, W., and Nicolson, T. (2017) Integration of Tmc1/2
into the mechanotransduction complex is regulated by Transmembrane O-methyltransferase in hair
cells. eLife 6:e28474.
Pacentine, I., and Nicolson, T. (2019) Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells. PLOS Genetics, in press.
Several post-doctoral fellow positions are available in the laboratory of Dr. Xiaolei Xu, Professor of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine. The successful applicants will join a team that is leveraging powerful zebrafish genetics to model human cardiovascular diseases, to decipher underlying mechanisms, and to develop new therapies. Applications are invited from candidates who have a strong background in molecular biology, genetics and/or cardiovascular diseases. Previous experience in cell culture, animal models of human diseases, and/or myofibril mechanics are favored, but not required. Qualified candidates must be self-motivated and have a strong commitment to basic research. Further enquires (enclosing a CV) regarding the scope and detail of the project should be addressed to: xu.xiaolei@mayo.edu or visit http://mayoresearch.mayo.edu/mayo/research/zebrafish/
Mayo Clinic College of Medicine is a not-for-profit organization that integrates research with clinical practices and education in multi-campus environment. Mayo offers an attractive benefit package. Salary will be determined by the successful candidate's experience.
Applications, including curriculum vitae and bibliography, summary of past accomplishments, and the names of three references, should be sent to:
Xiaolei Xu, PhD.
Mayo Clinic
Stabile 4-10
200 First Street SW
Rochester, MN USA 55905
Email: xu.xiaolei@mayo.edu
Phone number: 507-284-0685