Blog from October, 2018

Li Zhaoping's group in University of Tuebingen and the Max Planck Institute of Biological Cybernetics is setting up a zebrafish laboratory to investigate sensory and/or sensorimotor functions and mechanisms in the brain. For this purpose, Zhaoping is recruiting for students and postdocs (or staff scientists), with a starting date as soon as possible. The candidates should be a highly motivated individuals, skilled and experienced in various zebrafish neuroscience techniques such as imaging, behavioral experiments, optogenetics. The rodent research is part of an overall research program on computational and experimental neuroscience, see     

Interested individuals please contact


A Research Technician position is available in the laboratory of Dr. Jingli Cao at Weill Cornell Medical College, Cornell University in New York City from November 2018 or soon thereafter. The Cao lab is located in the newly established Cardiovascular Research Institute (CVRI) and the Department of Cell & Developmental Biology ( We aim to understand the basic mechanism of innate tissue regeneration by focusing on heart regeneration. The lab uses a combination of the zebrafish model, explant tissue culture, high-throughput sequencing, chemical screening, live imaging, and genome editing approaches (such as CRISPR/Cas9).


This position offers mentoring opportunities and opportunities for co-authorship on published manuscripts.  A bachelor’s degree and laboratory research experience are required. Prior experience in the zebrafish model or developmental biology is a plus. Candidates with interests in regenerative biology, heart disease, and zebrafish research are encouraged to send a cover letter, a CV, and a list of three references to



Postdoctoral research positions are available in the laboratory of Dr. Jingli Cao at Weill Cornell Medical College, Cornell University in New York City from December 2018 or soon thereafter. The Cao lab is located in the newly established Cardiovascular Research Institute (CVRI) and the Department of Cell & Developmental Biology. We aim to understand the basic mechanism of innate tissue regeneration by focusing on heart regeneration. The lab uses a combination of zebrafish model, explant tissue culture, high-throughput sequencing, chemical screening, live imaging, and genome editing approaches (such as CRISPR/Cas9). Please refer to our recent publications for further information (Dev. Cell, 2017. 42: 600–615; Nat. Protoc., 2016. 11(5):872-81; Development, 2016. 143(2):232-43;Nature, 2015. 522(7555): 226-30). 


Highly motivated individuals with interests in the field of tissue regeneration, heart disease and repair, and zebrafish model are encouraged to apply. The candidates with research experience in cell biology, developmental biology, and animal models are preferred, but not required. Candidates must hold a Ph.D. degree or equivalent. The successful applicants will join a dynamic team of scientists at CVRI and benefit from the unique, collaborative Tri-Institutional research environment (Weill Cornell Medical College, The Rockefeller University, and the Memorial Sloan Kettering Cancer Center). Weill Cornell Medical College offers subsidized housing and excellent benefits.


The positions will remain open until filled. Please send a cover letter describing their research background, interests, career goals, alongside a CV and names and contact information of three references in a single PDF file to Dr. Jingli Cao at

Apply now Job no: 523060
Work type: Faculty - Career
Location: Eugene, OR
Categories: Research/Scientific/Grants, Neuroscience

Department: Institute of Neuroscience
Rank: Research Assistant
Annual Basis: 12 Month

Review of Applications Begins
Application review begins immediately; to ensure consideration, complete applications must be submitted by November 5th, 2018; position open until filled

Special Instructions to Applicants 
Please submit a cover letter, resume and three professional references with your online application.

Department Summary
The Institute of Neuroscience (ION) is a group of biologists, psychologists, and human physiologists at the University of Oregon that has pooled its expertise to tackle fundamental questions in neuroscience – questions such as, "How do neural stem cells choose between self-renewal and differentiation?" "What mechanisms generate the large diversity of neurons within the brain?" "How do these neurons 'wire up' into functional circuits?" "How do neural circuits produce behavior?"

These questions are being explored at all levels of organization – from the relatively simple nervous systems of Drosophila, C. elegans, and zebrafish to the more complex networks in mice, owls, and humans.

ION boasts a highly collaborative faculty with expertise in genetics, development, electrophysiology, optogenetics, and functional MRI. As a result, students enrolled in our PhD program come away with the broad conceptual and technical skills necessary to run an independent neuroscience research lab or pursue many other related career paths. Our state-of-the-art facilities and excellent support staff allow ION members to progress rapidly by making exploratory or pilot experiments accessible.

We're passionate about creating an inclusive environment that promotes and values diversity. Research institutions that are diverse in gender, gender identity, race, sexual orientation, ethnicity, age, and perspective are proven to foster greater creativity and promote synergistic, collaborative innovation and interactions.

Position Summary
The Gnotobiology Technician will be primarily responsible for overseeing gnotobiotic zebrafish production and training. In addition, the technician will perform zebrafish husbandry tasks, including crossing, screening, and genotyping by PCR and by fluorescence microscopy. The technician will also perform routine lab tasks such as making solutions and ordering reagents, maintaining electronic records of zebrafish and microbial stocks, as well as a variety of molecular biology techniques including designing and cloning constructs for zebrafish transgenesis and creating transgenic zebrafish.

Minimum Requirements
Bachelor's degree biology or related field. Experience with molecular biology and/or microbiology techniques.

Preferred Qualifications
• Experience with zebrafish husbandry. 
• Experience with generating transgenic zebrafish. 
• Experience with electronic databases.

The University of Oregon is proud to offer a robust benefits package to eligible employees, including health insurance, retirement plans and paid time off. For more information about benefits, visit

The University of Oregon is an equal opportunity, affirmative action institution committed to cultural diversity and compliance with the ADA. The University encourages all qualified individuals to apply, and does not discriminate on the basis of any protected status, including veteran and disability status. The University is committed to providing reasonable accommodations to applicants and employees with disabilities. To request an accommodation in connection with the application process, please contact us at or 541-346-5112.

UO prohibits discrimination on the basis of race, color, sex, national or ethnic origin, age, religion, marital status, disability, veteran status, sexual orientation, gender identity, and gender expression in all programs, activities and employment practices as required by Title IX, other applicable laws, and policies. Retaliation is prohibited by UO policy. Questions may be referred to the Title IX Coordinator, Office of Civil Rights Compliance, or to the Office for Civil Rights. Contact information, related policies, and complaint procedures are listed on the statement of non-discrimination.

In compliance with federal law, the University of Oregon prepares an annual report on campus security and fire safety programs and services. The Annual Campus Security and Fire Safety Report is available online at

This is good news for international students who want to join the Master/PhD program in CYCU, TAIWAN. The research topic in Dr. Hsiao's lab will focus on 
(1) New genome editing and transgenic technique development in zebrafish
(2) New bioinformatic technology on NGS data analysis.
(3) Use zebrafish to establish human disease models (aging, cancer, obesity and behavior) and study ecotoxicity at molecular, cellular and behavioral levels     
The tuition and dormitory fee is free for all four years for those qualified candidates
Also can get financial supports from advisor for compensate for their life expense in Taiwan

The application dead line for Spring semester 2019 is 2019/2/1

Dr. Hsiao's website:   
Please contact Dr. Hsiao first at following mailbox (

On-line Application Website:
Please follow our instruction in the system.
1. Register in the system
2. Fill all the information, upload the required documents and complete the whole procedure in the system.
3. Down load the required documents, print out your application form from the system.
4. Sent the hardcopy of application form and application from to us by postal mail. Please must go through our on-line system and complete all the required procedure. Otherwise, we are not able to accept your application

Vacancy Reference Number005288Closing Date11 Nov 2018Salary£37,412 to £40,568 per annumAddressCentre for Developmental Neurobiology, King's College LondonDurationFixed term for 36 months

Applications are invited for a postdoctoral researcher position to join the lab of Professor Corinne Houart in the Centre for Developmental Neurobiology.

The Houart group works on CNS development and the successful applicant will pursue a BBSRC-funded research project which aims to understand how temporal regulation of early signalling activities controls forebrain size from fish to mammals, using zebrafish and mouse/human culture models. The successful applicant will benefit from the collaborative, friendly and interactive culture of the Centre for Developmental Neurobiology at King's College London and be able to access to state-of-the-art technology.

Candidates must be independently motivated to achieve results and be able to manage competing demands and deadlines. Microscopy/imaging skills, experience of using animals in developmental biology and training in neuroscience are essential. Basic programming skills are essential. Knowledge of neuroanatomy is desirable, as are microdissection skills.

This post will be offered on a fixed-term contract for 36 months

This is a full-time post, 35 hours per week

The selection process will include a panel interview and a presentation.

To apply, please register with the King's College London application portal and complete your application online.

For more information and to apply, click here

Contact Details

Professor Corinne Houart:

The Department of Biology at the University of Kentucky seeks two tenure-track faculty in the areas of Stem Cell Biology and in Emerging Pathogens to begin in the fall of 2019.

Assistant Professor in Stem Cell Biology

We seek candidates using innovative approaches to address fundamental questions in stem cell biology, and we encourage candidates working in any organismal or cellular system to apply. The ideal candidate will complement existing faculty strengths in regenerative biology, cell and developmental biology, genetics, genomics, and evolutionary biology. Interested applicants should apply online at:

Assistant Professor in Emerging Pathogens

We seek candidates using innovative approaches to fundamental questions in emerging pathogens and the study of infectious diseases that have newly appeared in a population, or have existed but are rapidly increasing in incidence or geographic range. We seek an innovative program employing microbial organisms to investigate fundamental questions about the ecology and evolution of pathogens, including but not limited to the evolution and function of hostmicrobiome interactions, microbiome colonization and community assembly, host-parasite interactions, and the genetics and evolution of pathogen traits. We encourage candidates interested in programs that integrate empirical approaches with theoretical, statistical, or computational methods. Interested applicants should apply online at:

With more than 500 life sciences faculty on one contiguous campus, there are excellent opportunities for scientific interaction and collaboration with programs in the Colleges of Medicine, Pharmacy, Engineering, Agriculture, and Arts & Sciences, the Markey Cancer Center, the Sanders-Brown Center on Aging, and the Center for Clinical and Translational Science, among others.

Candidates for both positions must have a Ph.D. or equivalent degree, postdoctoral experience (minimum 6 months) and previous research by the successful applicants must be published in high-quality scientific journals. We encourage applicants with evidence of an ability to obtain extramural grant support and/or some teaching experience. Responsibilities for the successful candidates include (1) establishment of an independent research program that is supported by awards from extramural agencies; (2) contribution to the teaching mission of the undergraduate program; (3) teaching and mentoring for graduate students and postdoctoral fellows; and (4) service for the department, university, and profession. Competitive start-up funds and renovated laboratory space will be provided.

As a department and university, we are strongly committed to creating an inclusive and effective teaching, learning, research, and working environment for all.

Applicants must include the following: (1) letter of application, (2) CV, (3) research plan (uploaded under Specific Request 1), (4) description of teaching interests (uploaded under Specific Request 2), and (5) a reflection on the applicant’s commitments, approaches, and insights related to inclusion, diversity, and equity (uploaded under Specific Request 3). Also provide the names and contact information for three references when prompted in the academic profile. This information will be utilized to solicit recommendation letters from your references within the employment system. 

For more details on the department and the university, visit us on the web ( or on social media (@ukybiology on Twitter, Facebook, and Instagram). Questions about the these searches should be addressed to Dr. Vincent Cassone, Chair, Department of Biology, University of Kentucky, 101D Thomas Hunt Morgan Building, Lexington, KY 40506;

Review of applications will begin October 29, 2018 and continue until the position is filled.

The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus. As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.

Two postdoctoral fellow positions are available in the laboratory of Dr. Gaurav Varshney. We are looking for highly motivated, passionate, and independent individuals with excellent interpersonal skills to play a key role in advancing the mission of the lab.


We are focused on tackling the huge challenge of systematically validating the flood of human candidate disease genes identified in various genome- wide association (GWAS) and whole-exome sequencing studies by developing disease models in zebrafish.


The successful applicants will use zebrafish, and the emerging genomic technologies such as CRISPR/Cas9, single-cell genomics to understand the disease pathology of hearing, and vision disorders.  Our research interests span multiple disciplines: genetics, genomics, molecular biology, and developmental biology.


A recent doctorate in Biological Sciences or related field with experience in Molecular Biology, Cell & Developmental Biology, and Genetics is required. Experience with zebrafish is desirable, but not essential. 


Please send your application to with the following items:

1) CV

2) A list of three references with their contact information


The Varshney lab ( is located in the Functional and Chemical Genomics Program at the Oklahoma Medical Research Foundation (OMRF) (, Oklahoma City, Oklahoma. OMRF is an independent, not-for-profit, biomedical research institute adjacent to the campus of the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. OMRF investigators enjoy close scientific interactions with OUHSC faculty and participate in OUHSC graduate programs. Additional information about the OMRF Postdoctoral program can be found at


ERA Chairs Group Leader position

at the International Institute of Molecular and Cell Biology in Warsaw, Poland

The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) invites applications for the position of a Group Leader with a planned starting date in November 2019.

IIMCB provides stimulating and interdisciplinary research environment and opportunities of the large biomedical campus with the possibilities of selecting PhD students and postdoctoral scientists from leading Polish academic institutions. The Institute is equipped with state-of-the-art technology, has excellent core facilities and supportive administration, including a grant office. IIMCB benefits from numerous generous funding schemes for basic research through grants from international and national sources (

We are searching for a Group Leader, an excellent mid-career investigator with a PhD degree, outstanding and transformative research accomplishments and demonstrated leadership experience. The successful candidate should be conducting high-level research that would expand and build on the existing strengths of the Institute in the fields of intracellular trafficking, mTOR pathways, calcium and iron homeostasis, DNA repair and modification, RNA structure-function relationships, and gene regulation during embryonic development. Moreover, he/she is also expected to develop new research ideas and provide intellectual leadership in building the IIMCB renown on the international scene.

The position is funded through the H2020 ERA Chairs project recently obtained by IIMCB.


IIMCB offers:

  • Group Leader position (professorial level) on an initially 5-year appointment with the possibility of extension, subject to external merit-based evaluation
  • Research independence
  • Highly competitive salaries for the PI and his/her team members
  • Start-up funds
  • Laboratory space and unlimited access to cutting-edge equipment
  • Support in applications for additional grant funding
  • Full technical, administrative and organizational support from professional English-speaking personnel


Applications should include:

  • a cover letter explaining reasons for the application
  • a Curriculum Vitae including a list of publications and grants
  • a statement of scientific achievements (up to 1 page)
  • a summary of the applicant’s future research plans (2 pages)
  • contact details of two academic reference persons
  • copies of three most important papers


Please include the following statement in your application: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Str., 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link


Deadline for applications is October 31st, 2018. Applications should be submitted by e-mail to Specific inquiries can be addressed directly to Marcin Nowotny, PhD, Head of Laboratory of Protein Structure,

This competition is supported by the project entitled: MOlecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence, acronim: MOSaIC under the H2020 ERA Chairs program.



The Braasch Lab (aka Fish EvoDevoGeno Lab) in the Integrative Biology Department at Michigan State University (MSU IBIO) is looking to fill an immediate opening for a lab manager/research lab technician position. We are looking for an enthusiastic, highly motivated, and responsible individual to join our research team that use different fish species as model organisms to study the genomic basis of vertebrate development, evolution, and disease.


The Braasch Lab focuses on genomic and developmental changes that contribute to major transitions during the course of vertebrate evolution and studies evolutionary novelties at the levels of genome structure, gene family evolution, and gene regulation. We combine comparative genomics with analyses of molecular evolution and functional genetic and developmental approaches using a variety of fishes as our model systems (zebrafish, medaka, spotted gar, killifishes, and others)


The ideal candidate will be expected to work as both lab manager (~50% time commitment) and research technician (~50%) and perform and document a variety of tasks in a timely, accurate and detailed manner, meet with the PI Ingo Braasch on a weekly basis and provide support to graduate students and postdocs in the lab. Primary duties may include, but are not limited to: perform experiments under supervision of laboratory head; provide support with molecular biology, next-generation sequencing, and developmental biology projects; ordering supplies and equipment; lab supply and equipment maintenance and organization; maintaining and documenting lab cleanliness and safety standards; managing lab databases (such as plasmid database, antibody database); equipment maintenance; supervising and training undergraduate students, staff and volunteers.


This is a full-time appointment and offers excellent benefits (healthcare, dental, etc.). The initial appointment will be for a 6-month probationary period, after which yearly reappointments will be made for successful and productive candidates. Salary commensurate with experience. 



MSU IBIO has a strong research commitment to vertebrate biology with a highly collaborative community of groups working on fish evolution, genomics, development, population genetics, neuroscience, behavior, ecology, and conservation, allowing for vibrant exchange among fields, methods and model systems.


For details and to apply, please go to The posting number is 538133.


Closing date for applying to this position is October 16, 2018.


For questions related to this job posting, please email Ingo Braasch (


Follow us on twitter: @fishevodevogeno


A glioblastoma zebrafish model to understand the molecular mechanisms underpinning the growth and invasiveness of brain cancers


Glioblastoma multiforme is the most common and deadliest form of brain cancer and is highly resistant to therapeutic strategies. Glioblastomas are known to contain a high number of microglia/macrophages. This microglial/macrophage invasion supports tumour growth and the infiltration of surrounding brain tissue by glioma cells. Importantly, the presence of macrophages/microglia positively correlates with glioma grade and prognosis. However, the exact nature of microglia/macrophage-glioma interactions is not well understood but our experimental design provides a unique opportunity to study the cellular and molecular mechanisms that promote malignant glioma growth.

In this project we will establish the first zebrafish model in Australia to study glioblastoma growth and invasiveness in real-time in the living brain. Our team has established a collaboration with the University of Edinburgh to study microglia-brain tumour cell interactions in vivo in the larval zebrafish brain. We will be using state-of-the-art fluorescent labelling and visualisation techniques that allow us to track tumour progression and the impact of microglia to regulate that process. Targeting these microglia interactions may provide future therapeutic interventions to delay or even halt the progression of the tumour. In addition, our experimental system will provide unique insights into how microglia precursors may be used as a non-invasive route of access to the brain.


Microglia and macrophages that have colonised the glioblastoma display pro-tumoral characteristics and interfering with the activation profile of these cells may delay tumour progression.


We will establish the first glioblastoma model in zebrafish in Australia to test how microglia interact with human brain cancer cell lines. We hypothesize that manipulating microglia-tumour interactions will affect tumour progression. Understanding microglia-glioblastoma interactions will provide important insights into glioblastoma pathogenesis.


We are seeking a highly motivated PhD candidate with either experience in zebrafish or cancer research. 

The project is established in collaboration with Prof Helen Rizos, Macquarie University and may involve a lab visit in Edinburgh, Scotland.


Information about yourself should include your CV and a description of scientific interests and your motivation.

Please send your details to 

Marco Morsch <> or Manuel Graeber <>

A fully-funded postdoctoral position is available in the laboratory of Fumi Kubo ( at National Institute of Genetics in Mishima, Japan. Our newly established group is interested in neural circuit that transforms visual motion information into goal-directed behavior. We aim to understand the underlying mechanisms at cellular and network levels using zebrafish as a model organism. Our lab takes multi-disciplinary approaches that combine behavioral, genetic and optic techniques (please see Kubo et al., Neuron, 2014, Förster et al., Sci Rep., 2017, Förster et al., Methods., 2018).

Successful candidate will investigate the role of visual motion in generating behavior. Applicants should have a PhD in Neuroscience or related field, be highly motivated, and have strong analytical and communication skills. Candidates with backgrounds in in vivo calcium imaging and/or programming skills are particularly encouraged to apply. Previous experiences working with the zebrafish model are preferred, but not required.

Salaries are determined according to the institute’s guideline. The contract is annually renewed based on evaluations (until November 2022). The National Institute of Genetics also hosts the lab of Koichi Kawakami and offers collabortaive research environment.

To apply, please email a PDF file containing the following materials to Fumi Kubo (
1) CV, including a list of publications and contact information for 2‐3 references
2) Cover letter describing previous research, research interests and career goals

For more information, please contact at

Fumi Kubo, Ph.D.
Associate Professor
Systems Neuroscience lab
National Institute of Genetics

The Department of Genetics at the Institute of Physiology and Pathology of Hearing in Warsaw is seeking a candidate for a post-doctoral research assistant position in the framework of SONATA BIS6 project „Integrating whole genome sequencing and zebrafish functional studies to uncover new molecular basis of autosomal dominant hearing loss” funded by the National Science Center, Poland.

Research objectives:

Autosomal dominant hearing loss (ADHL) is the second most common form of hereditary hearing loss (HL) and detection rate of causative mutation reaches approximately 65%. This suggests that performing extensive genetic testing, based on high-throughput DNA sequencing on families with ADHL may lead to a discovery of novel disease genes. To determine the function of the newly identified genes/alleles in the development of the auditory organ we will use a zebrafish model system, which is a valuable animal model for studying development and function of the vertebrate inner ear. We will analyze hearing defects by investigating the morphology of the auditory system and use a range of behavioral studies testing the hearing responses and balance dependent on function of the hearing apparatus. The main purpose of the project is to detect novel molecular basis of ADHL and to implement the zebrafish animal model to dissect the underlying mechanism of action of the newly discovered genes and alleles. 


  1. PhD degree in biological, medical or other related fields obtained no longer than 7 years prior to employment in the project 
  2. experience in laboratory work in the field of genetics and molecular biology; experience in animal studies, in particular on the zebrafish model is highly desirable
  3. scientific achievements documented by publications in international journals from the JRC list
  4. high motivation for scientific work documented by scientific activities, e.g. participation in conferences, courses, obtained scholarships, grants, patents, awards, distinctions, participation in scientific exchange with other institutions
  5. proficiency in English (spoken and written)
  6. ability to present research results
  7. conscientiousness, accuracy and good organizational skills
  8. communicativeness and ability to work in a team


Candidate responsibilities:

Person employed at this position will conduct research tasks of the SONATA BIS6 project No. 2016/22/E/NZ5/00470 entitled "Integrating whole genome sequencing and zebrafish functional studies to uncover new molecular basis of autosomal dominant hearing loss". As part of the project, the post-doc will be required to thoroughly analyze the literature and data available in different databases, carry out next-generation sequencing (NGS) and functional experiments on a zebrafish model. The post-doc will be also obliged to analyze and present the results and prepare scientific papers.


Appointment terms:

• Full-time; time-definite employment (38 months)

• Gross salary 5900 PLN/month;

• Application deadline is November 5th, 2018.


Application should contain:

  1. motivation letter with description of scientific interests
  2. CV with a list of scientific, didactic and organizational achievements (publications, conferences, workshops, etc.)
  3. copies of a PhD degree diploma and higher education diploma
  4. at least one recommendation letter 
  5. statement of consent to the processing of personal data: “I hereby agree to the processing of my personal data, included in the application documents by the Institute of Physiology and Pathology of Hearing in Warsaw, 10 M. Mochnackiego Str., 02-042 Warsaw, for the purpose of carrying out the current recruitment process”

Modes of submitting applications:

Application documents should be sent by regular mail to the Institute of Physiology and Pathology of Hearing 10 M. Mochnackiego Street; 02-042 Warsaw, Poland. Please label your application with the following headword: “Competition for a post-doc position at the Department of Genetics IFPS". Documents should include the applicant’s name, mailing address and telephone number. Applications received after the deadline will not be considered.

Applications will be evaluated by the recruitment committee headed by the project principal investigator – Monika Ołdak MD, PhD. Only selected candidates will be invited for an interview.

Questions regarding the recruitment process should be directed to:

The team "GEnetics of NeuroDEVelopment" (GENDEV) at the Lyon
Neuroscience Research Centre (CRNL) is seeking a highly motivated
post-doctoral fellow for a fully funded 3-years position to work on a
project aiming to unravel the role played by minor splicing in embryonic
development through the study of zebrafish models of a family of
neurodevelopment disorders.
The 36 months postdoctoral position (ANR funding) is available from
October 2018.


Candidates must hold a PhD degree in Genetics, Neurosciences,
Biochemistry, Cell Biology or other related fields, and a postdoctoral
experience of less than 3 years. Excellent skills in molecular and cell
biology techniques and in zebrafish model are required; experience in
neuroscience would be a bonus.
Fluency in oral and written French and/or English is required.

Project description

Biallelic mutations in the non-coding gene RNU4ATAC were identified by
our group in the Taybi-Linder syndrome (TALS, OMIM 210710, Edery P et
al. 2011 Science). TALS is a rare autosomal recessive syndrome
characterized by severe brain malformations. RNU4ATAC, the non-coding
human gene responsible for TALS is transcribed into U4atac snRNA, a
component of the minor (also called U12) spliceosome, a
ribonucleoproteic complex that removes a restricted subset (<1%) of
introns during the mRNA maturation process. Recently, two other very
rare congenital disorders have also been attributed to biallelic
RNU4ATAC mutations. We combine multiple approaches including genetic
epidemiology, clinical genetics, genomics, transcriptomics,
bioinformatics, molecular biology, cell biology and zebrafish models to
decipher the molecular causes and physiopathology of RNU4ATAC-associated
syndromes to improve knowledge on the role of minor (U12) intron
splicing in brain development and to allow accurate information, genetic
counselling and medical care of patients with a disorder of brain
The candidate will perform in zebrafish morpholino-driven and CRISPR
gene editing, development and morphology analyses, transcriptional
profiling via RNA-seq, and general molecular biology techniques to
generate and characterize phenotypes and molecular and cellular defects
associated with RNU4ATAC mutations.

Scientific environment

The GENDEV research team was created in 2016 at the Lyon Neuroscience
Research Centre (CRNL) and is composed of clinical and molecular
geneticists. The CRNL is a neuroscience research centre located within
new buildings next to four large hospitals that integrates the
multidisciplinary expertise of 380 members (14 teams) with a synergistic
approach of brain organization and development, cognitive functions and
mental states in physiological and pathological conditions, using
various a broad spectrum of research tools ranging from cognition to
genetics. The position will provide opportunities for a young researcher
to benefit from the GENDEV collective first-rate expertise on human
syndromes, genomics, transcriptomics, bioinformatics, biochemistry and
zebrafish model to perform a multidisciplinary research study.

Contact information

To apply, please send a cover letter and a CV including contacts for
references to and before 30 November 2018.

The University of Miami is considered among the top tier institutions of higher education in the U.S. for its academic excellence, superior medical care, and cutting-edge research. At the U, we are committed to attracting a talented workforce to support our common purpose of transforming lives through teaching, research, and service. Through our values of Diversity, Integrity, Responsibility, Excellence, Compassion, Creativity and Teamwork (DIRECCT) we strive to create an environment where everyone contributes in making UM a great place to work. We are one of the largest private employers in Miami-Dade County; home to more than 13,400 faculty and staff from all over the world.

The Postdoctoral Associate supports research activities at the University, under the supervision of a faculty member, in order to advance their knowledge and/or be documented by scientific publications. 

Primary Duties and Responsibilities: 
•Works and collaborates on studies related to field of study. 
•Ensures the design, development, execution and implementation of scientific research and/or development in collaboration with a research team. 
•Investigates the feasibility of applying a wide variety of scientific principles and theories to potential inventions and products. 
•Maintains substantial knowledge of state-of-the-art principles and theories. 
•Contributes to scientific literature and conferences, when appropriate. 

Knowledge, Skills, and Abilities: 
• Must have excellent communication skills, oral and written. 
• Must be detail oriented. 

Duties specific to College of Arts & Sciences: 

The Rieger lab is searching for a postdoctoral scholar in the Biology Department at the University of Miami. 

The postdoctoral scholar will be working on mechanisms of chemotherapy-induced peripheral neuropathy using primarily zebrafish as a model system. Chemotherapy-induced peripheral neuropathy is a side effect of chemotherapy that affects 60-70% of patients for which currently no cures exist. The Rieger lab has developed a zebrafish model with which to study the mechanisms underlying sensory axon degeneration due to one particular chemotherapeutic agent, paclitaxel. Studies in this model identified a target, MMP-13, which when inhibited alleviates neuropathy. The goal is to analyze the role of paclitaxel in MMP-13 dysregulation and axon degeneration. This project involves in vivo imaging of zebrafish. A second goal is to collaborate with medicinal chemists to develop new inhibitors and test them in zebrafish and rodents in preparation for clinical studies in collaboration with the University of Miami Medical School. 


Candidates must have a Ph.D. in Biology, Neurobiology, or a related discipline, and experience in conducting research with zebrafish, molecular biology and confocal imaging. Other important qualifications are a background in statistical methods, strong work ethic and strong organizational and time management skills. Other qualifications include problem-solving skills, experience in manuscript writing, a track record of publications, and independent research experience. Knowledge of medicinal chemistry or drug development are preferred. 

Apply online at 
Position # P100041395