School of Biology and Ecology (SBE) University of Maine, Orono, ME
Position: 9-month tenure-track academic appointment as Assistant Professor of Developmental Biology in the School of Biology and Ecology, with a 50% research and 50% teaching split
Duties and Responsibilities:
Teaching - Teaching responsibilities will include an intermediate-level undergraduate course in developmental biology of animals (BIO 336) taught every spring semester as a 4 credit lecture and lab, and an upper-level undergraduate histology course (BIO 450) or another upper-level undergraduate biomedical capstone course in an area of expertise taught every fall semester as a 4 credit lecture and lab. The successful candidate will also be expected to advise undergraduate majors, to guide undergraduate research and honors thesis investigations, and to recruit and to mentor graduate students.
Research – The successful candidate is expected to develop an innovative, nationally competitive research program that is funded by external grants. Areas of research interest and expertise may include, but are not limited to, development, regeneration, or aging of any tissue or organ system. Opportunities are available for collaboration with faculty in the School of Biology and Ecology, the Graduate School for Biomedical Sciences and Engineering, the Center on Aging, the Center for One Health and the Environment, Jackson Laboratory, and Mt. Desert Island Biological Lab. Maine is an IDEA-AREA state with NIH, an NSF-EPSCoR state, and UMaine is part of a state- wide INBRE award.
Qualifications – Applicants should possess a Ph.D. in a relevant area of biological sciences, with specific training in developmental biology. Additional postdoctoral training is highly desirable, and candidates should possess excellent oral and written communication skills. The ability to conduct high-caliber scientific research and to publish in respected peer-reviewed journals is an essential requirement for this position.
To apply - Applicants should submit a cover letter, a C.V., a statement of research interest (2 pages maximum), a statement of teaching philosophy and experience (2 pages maximum), a 1- page statement on the applicant’s approach to diversity, equity, and inclusion in Academia, and the names and contact information for three referees. All materials must be submitted in PDF format through the online application system at https://umaine.hiretouch.com. Review of applications will begin on September 10, 2018 and will continue until the position is filled. Applicants should note that incomplete applications cannot be considered. Appropriate background checks will be required.
Inquiries or questions about this job announcement can be forwarded to Dr. Clarissa Henry, chair of the search committee (clarissa.henry@maine.edu).
The University of Maine is the flagship campus of the University of Maine System and is the principal graduate institution in the state. It is the state's Land Grant and Sea Grant University, with an enrollment of 12,000 students. Located in the Town of Orono near the greater Bangor area, the University provides easy access to diverse cultural activities, excellent public schools, friendly neighborhoods where children can walk to school, high quality medical care, modest traffic, trails and paddling opportunities, and a reasonable cost of living. The University of Maine is located just 60 miles from the beautiful Bar Harbor area and Acadia National Park, and is two hours north of Portland, which offers a host of cultural activities and a thriving restaurant scene.
The University of Maine is an EEO/AA employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, age, disability, protected veteran status, or any other characteristic protected by law.
Smith College Geneticist, Genomicist
Smith College is seeking a biologist with expertise in genetics and
genomics to fill a tenure-track position as Assistant Professor of
Biology beginning July 1, 2019.
A strong background in the generation and/or analysis of genetic
and genomic data, a PhD by the time of appointment, and a
commitment to undergraduate education are essential; postdoctoral
experience is desirable. Teaching responsibilities will include a
200-level course with laboratory in genetics and molecular biology,
and a 300-level course with laboratory in genomics. Participation in
the introductory sequences is also expected, though on a rotational
schedule. The candidate must demonstrate a commitment to
developing an active research program, including supervision of
undergraduate research. We are hoping to attract applicants
whose research interests further broaden the organismal expertise
of our department.
State-of-the-art resources at Smith include the Centers for Microscopy
& Imaging, Molecular Biology, and Proteomics, the Botanic Garden,
an accredited animal care facility, and a high performance computing
center. The new faculty member might also contribute to Smith's
programs in Biochemistry, Computer Science, Environmental Science,
Neuroscience, and/or Statistics & Data Sciences. The Five College
Consortium, comprised of Smith, Amherst, Mount Holyoke, and
Hampshire Colleges and the University of Massachusetts - Amherst,
provides a rich intellectual and cultural life for faculty and students,
as well as opportunities for collaborative research and mentoring of
doctoral students.
Submit application at https://apply.interfolio.com/53351 with a cover
letter, curriculum vitae, a teaching statement, a research statement, a
diversity statement addressing commitment to enhancing access and
inclusion, and three confidential letters of recommendation. Review
of applications will begin on October 1, 2018.
Diversity and a culture of inclusion among students, faculty,
administration, staff, and curriculum are crucial to the
mission and values of Smith College. Smith welcomes applicants
from a range of backgrounds including, but not limited to, those based
on ability, age, ethnicity, gender, gender identity, national origin,
race, religion, sexual orientation and veteran status.
Smith is committed to providing an accessible application process
for individuals with disabilities and encourages applicants to request
any needed accommodation(s).
Smith College is an EO/AA/Vet/Disability Employer. Women,
underrepresented racial groups, veterans and individuals with disabilities
are encouraged to apply.
Pediatric Neurodevelopmental and Disease
A position for a staff scientist or research assistant or associate professor is available for studies in neurodevelopment and neurodisease gene pathophysiology and therapeutics discovery in the Bonkowsky lab (http://medicine.utah.edu/pediatrics/labs/bonkowsky/). The primary experimental model system is the zebrafish with potential applications to mouse, iPSCs, and human.
The projects include the use of zebrafish as an experimental model to study and develop human leukodystrophies and other conditions, with extension to drug discovery and testing in other systems. We apply advanced genetic approaches, including transgenesis, genome editing (CRISPR/Cas9), optogenetics, behavior screening, and confocal microscopic imaging techniques (e.g. Gao et al., eNeuro, 2018; Strachan et al., Human Molecular Genetics, 2017; Son et al., Nature Scientific Reports, 2016).
Our research group is an interdisciplinary, collaborative group. The Bonkowsky laboratory is located in the Department of Neurobiology with access to a large modern zebrafish facility, imaging core facilities, and a vibrant scientific community including more than ten zebrafish labs.
Qualifications: PhD or MD/PhD or similar experience. Strong background and experience in experimental sciences (such as molecular biology and/or biochemistry) is necessary. Prior experience in genetics, developmental biology, neuroscience, sequencing, programming, and imaging would be advantageous. Primary responsibilities will include day-to-day oversight of lab members and experiments; performing experiments; preparing figures and publications; and applying for funding. Candidates should be aware of opportunities for advancing compounds to therapies including collaborations with drug companies; and collaborations with bioengineering for novel device development. The lab also has a clinical research component, and familiarity with IRB applications and maintenance; human patient consent process; blood/DNA draws; next-generation sequencing; and large database analysis; would be of additional benefit.
Candidates should be collegial and independent with good communication skills, team mentality, and a demonstrated track record. Applicants should have U.S. citizenship or a green card. Funding for salary is guaranteed for five years, with expectations of long-term success.
The lab and setting are an innovative, well- equipped and scientifically stimulating surrounding.
Women and under-represented minorities are especially encouraged to apply. The University of Utah is an Equal Opportunity Employer.
Applications should include a ½ page letter of description of their career and research, a CV, and the names and contact information of three academic references, and be sent to:
Dr. Josh Bonkowsky
E-Mail: joshua.bonkowsky@hsc.utah.edu
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=99907
Project Description
Project aim:
Our aim is to use genetic and developmental analysis of zebrafish to identify novel alleles and molecular mechanisms contributing to core behaviors predictive of vulnerability to drug addiction: drug seeking and impulse control, with a focus on nicotine addiction.
Significance:
Addiction is one of the major mental health disorders in the world. In the US the cost of addiction in health care and associated costs is estimated at over $700 billion each year with tobacco being responsible for over half of these costs ($425 billion) [1, 2].
Tobacco use was declared a world-wide epidemic by the World Health Organization (WHO, 2008) due to its dramatic impact on a diverse set of disease-related mortalities including cardiovascular disease and cancer. In 2014 cigarette use cost the US $170 billion in excess health care expense and another $156 billion in productivity loss per year [1, 3]. Despite the overall encouraging reduction of smoking rates, approximately one in five adults in America continues to smoke, a rate largely unchanged in the last five years[1, 3].
Despite the many novel insights from psychosocial, genetic, neurocognitive, neuroimaging, and pharmacological addiction research, currently available treatments are still not very effective and addiction, including smoking, remains a chronic-intermittent disorder for the vast majority of patients seeking treatment: Relapse rates of 50-70% within a year are common [4]. Thus there is a vital need for increased understanding of the factors influencing vulnerability to addiction to help identify vulnerable individuals and to inform treatment strategies and uncover novel druggable targets.
Although estimates vary, there is clear evidence for a genetic link between vulnerability to addiction, as well as quit rates and likelihood to relapse[5,6]. For example, results from twin studies suggest that 33–71% of the variation in liability to nicotine dependence and 48–66% of the variation in alcohol dependence can be attributed to heritable influences. A similar range for genetic heritability of illicit drug addiction and gambling has been reported ([9] and refs therein). Furthermore, genetic factors are partly responsible for, not only the comorbidity across addictions, but also between addictions and other mental illness (for example, autism and bipolar disorder). Increased understanding of the genetic factors that influence vulnerability to addiction and the cell biological mechanisms by which they act will, ultimately, lead to the development of novel therapeutics and a consequent impact on public health: ‘Each discovery of a biologically relevant locus is a potential first step in a translational journey’ [10]
Research Design:
Our group aims to use screens of ENU-mutagenized zebrafish lines and analysis of empirically derived candidate mutants to identify genes affecting two addiction phenotypes: nicotine reward and impulsivity. There is strong evidence that the neural circuits that underlie reward and addiction are evolutionarily conserved between humans and zebrafish [11-16]. Zebrafish show a robust conditioned place preference (CPP) reward response to nicotine that is ameliorated by drugs used in human cessation therapy demonstrating conserved neural pathways. Further our pilot data indicates that genes found to influence zebrafish CPP or impulse control also influence human behavior. These findings support the argument that zebrafish screens can be used to identify genes and pathways for reward and addiction as well as potential therapeutics as for other human disorders [17, 18].
This PhD is part of a collaboration with Elisabeth Busch-Nentwich at the Sanger Institute and Cambridge University. The successful candidate will work with bioinformaticians at Cambridge to identify changes in gene expression following chronic and/or developmental exposure to nicotine that correlate with changes in behaviour predictive of vulnerability to drug addiction. We shall then generate and characterise lines of fish carrying mutations in these candidate genes. The student will be trained in RNAseq analysis, developmental neurobiology and behavioural techniques.
Funding Notes
The studentship, expected to start January 2019, is funded by NIH and is open to applicants worldwide. It will cover tuition fees and provide an annual tax-free maintenance allowance for 3 years at Research Councils UK rates (£16,777 in 2018/19).
Applications are invited from outstanding candidates with or expecting to receive a first or upper-second class honours degree in an area relevant to the project. A masters degree is desirable, but not essential.
Informal enquiries can be sent to Dr Caroline Brennan (c.h.brennan@qmul.ac.uk). For formal applications, please submit an online application before the stated deadline.
References
1. Services., U.S.D.o.H.a.H., The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, 2014.
2. Center, N.D.I., National Drug Threat Assessment. Washington, DC: United States Department of Justice, 2011.
3. Xu, X., et al., Am J Prev Med, 2015. 48(3): p. 326-33.
4. Brandon, T.H., J.I. Vidrine, and E.B. Litvin, Annual review of clinical psychology, 2007. 3:257-84.
5. Munafo, M., et al., Nicotine Tob Res, 2004. 6(4):583-97.
6. Ducci, F. and D. Goldman,. Psychiatr Clin North Am, 2012. 35(2):495-519.
7. Goldman, D., G. Oroszi, and F. Ducci, Nat Rev Genet, 2005. 6(7):521-32.
8. Li, M.D. and M. Burmeister, Nat Rev Genet, 2009. 10(4):225-31.
9. Agrawal, A., et al., Transl Psychiatry, 2012. 2:e140.
10. Hirschhorn, J.N., N Engl J Med, 2009. 360(17):1699-701.
11. Darland, T. and J.E. Dowling, Proc Natl Acad Sci U S A, 2001. 98(20):11691-6.
12. Kily, L.J., et al., J Exp Biol, 2008. 211(Pt 10):1623-34.
13. Ninkovic, J., et al., J Neurobiol, 2006. 66(5):463-75.
14. Bretaud, S., et al., Neuroscience, 2007. 146(3):1109-16.
15. Bosse, G.D. and R.T. Peterson, Behav Brain Res, 2017. 335:158-166.
16. Klee, E.W., et al., Nicotine Tob Res, 2011. 13(5):301-12.
17. Rennekamp, A.J. and R.T. Peterson, Curr Opin Chem Biol, 2015. 24:58-70.
18. Zon, L., Cell Stem Cell, 2014. 14(2):146-8.
A grant-supported postdoctoral position aimed at defining pathogenic mechanisms of pediatric disease is available immediately in the Steet lab within the Research Division of the Greenwood Genetic Center (GGC). The GGC is a non-profit clinical, diagnostic and research center whose mission is to advance diagnoses and treatment for children with rare genetic diseases. The Research Division is equipped with state-of-the-art technology and equipment, including a new aquaculture facility. This position offers a unique opportunity to engage directly with clinical and molecular geneticists to better understand the genetic basis and molecular pathogenesis of inherited disorders.
We are seeking a highly motivated individual with experience in animal systems and genome editing who will work to address complex questions regarding disease pathogenesis. Zebrafish experience and expertise with microscopy is preferred. The successful candidate will use a combination of cell and animal systems in a highly collaborative environment to investigate disease mechanisms at a molecular and cellular level. Applicants are expected to have a strong record of first author publications from their Ph.D. work, experience with molecular and cell biological techniques and skill in both written and verbal communication. Interested applicants should submit a CV and the names of three references to Dr. Richard Steet (GGC Director of Research) and Dr. Heather Flanagan-Steet (Director of Functional Studies) at careers@ggc.org. The Greenwood Genetic Center is an Equal Opportunity Employer.
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A funded PhD position (3 years) is available in the Neural Circuits and Behavior lab, headed by Johann Bollmann, to study visual information processing and motor control in the zebrafish model system.
Our research aims at acquiring a mechanistic understanding of how neural circuits in the vertebrate CNS control visually guided behaviors at the level of synapses, cells and circuits. The PhD candidate will pursue his/her project as a member of an interdisciplinary team. Specifically, the PhD project involves the application of multiphoton microscopy and visual stimulation techniques to functional circuit analysis in the zebrafish visual system. In the course of the project, the PhD candidate has the opportunity to learn state-of-the-art functional imaging methods, targeted single cell electrophysiology and quantitative analysis of visually guided behaviors (e.g. Gabriel et al, Neuron 2012, Preuss et al, Curr. Biol. 2014).
The successful candidate will be part of an interdisciplinary team in an international research environment. The Institute of Biology I also hosts the labs of W. Driever, A. Straw, D. Reiff, M. Wittlinger. The dynamic neuroscience community at the University of Freiburg (www.neuro.uni-freiburg.de) provides ample opportunity for interaction and collaboration, e.g. Freiburg Neuroscience, Bernstein Center Freiburg, Neurex Neuroscience Network (Freiburg, Basel, Strasbourg).
Requirements: Diploma or Master degree in a relevant field, e.g. neuroscience, biology, physics, biomedical engineering. Genuine interest in quantitative cellular and systems neuroscience. Practical experience related to the topic (e.g. biomedical optics, electro/-optophysiology) advantageous. Fluent in English. Practical knowledge in programming (e.g. LabView, Python, Matlab) desirable.
To apply, please send CV, a brief statement (< 1 page) of research experience and motivation, and names of 1-2 references via e-mail.
Job Information:
Closing date: 2018-09-30
Starting date: 2018-10-01
Institution: University of Freiburg
Department: Institute of Biology I
Contact information:
Prof. Dr. Johann Bollmann
University of Freiburg
Institute for Biology I
Hauptstrasse 1
D-79104 Freiburg, Germany
A funded postdoctoral position is available in the Neural Circuits and Behavior lab, headed by Johann Bollmann, to study visual information processing and motor control in the intact vertebrate nervous system.
Our resesarch aims at identifying fundamental mechanisms of how visual information is encoded and processed in the intact brain. In an interdisciplinary team, we investigate pathways and neuronal coding schemes in sensory circuits and motor command centers underlying complex visually guided behaviors in zebrafish.
The project involves state-of-the-art in vivo functional imaging to measure neural network dynamics. Targeted patch-clamp recordings will be used to determine single cell function and synaptic connectivity. Optogenetic manipulation will be used to test candidate mechanisms of visual circuit function. We have long-standing and unique experience in analyzing structure and function of neural circuits in zebrafish using multiphoton imaging, targeted patch-clamp recordings and quantitative behavioral analysis (e.g. Gabriel et al, Neuron 2012; Preuss et al, Current Biology 2014). The position is part of an interdisciplinary team in an international research environment. The Institute of Biology I also hosts the labs of W. Driever, A. Straw, D. Reiff, M. Wittlinger. The dynamic neuroscience community at the University of Freiburg (www.neuro.uni-freiburg.de) provides ample opportunity for interaction and collaboration, e.g. Freiburg Neuroscience, Bernstein Center Freiburg, Neurex Neuroscience Network (Freiburg, Basel, Strasbourg).
Requirements: Excellent PhD thesis, e.g. in neuroscience, neurobiology or biophysics, and a high quality first author paper. Research experience in single cell electrophysiology or functional Ca2+ imaging/laser scanning microscopy in genetic model organisms. Fluent in English. Practical knowledge in programming (e.g. Python, Matlab, LabView) is desirable.
To apply, please send CV, a brief statement of research experience and motivation, and names of two references via e-mail.
Job Information:
Closing date: 2018-09-30
Starting date: 2018-10-01
Institution: University of Freiburg
Department: Institute of Biology I
Contact information:
Prof. Dr. Johann Bollmann
University of Freiburg
Institute for Biology I
Hauptstrasse 1
D-79104 Freiburg, Germany
johann.bollmann@bio.uni-freiburg.de
www.bollmannlab.org
A fully funded postdoctoral position is available to study vascular development, angiogenesis, and lymphangiogenesis in the zebrafish in the laboratory of Dr. Brant Weinstein in the NICHD Division of Developmental Biology (DDB) in Bethesda, Maryland. The Weinstein laboratory uses a variety of molecular, cellular, genetic, transgenic, microscopic imaging, and next-gen sequencing approaches to study the specification, patterning, and differentiation of developing blood and lymphatic vessels. Some of our current areas of research interest include endothelial specification and differentiation, assembly of vascular networks and the cues that guide their patterning; morphogenesis of vascular tubes, regulation of vascular integrity, and isolation and molecular characterization of novel vascular-specific mutants. The scientific environment, resources, and stipend support for this position are superb. For more information on our research, see https://science.nichd.nih.gov/confluence/display/svo/Home
Interested applicants should have a Ph.D. or M.D. and less than 3 years' postdoctoral experience. To apply, send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to weinsteb@mail.nih.gov and to amy.parkhurst@nih.gov.
NIH is an equal opportunity employer.
A fully funded postdoctoral position is available to study epigenetics of development in the zebrafish and in complementary cavefish, mouse, and cell culture models in the laboratory of Dr. Brant Weinstein in the NICHD Division of Developmental Biology (DDB) in Bethesda, Maryland. The Weinstein laboratory uses a variety of molecular, cellular, genetic, transgenic, microscopic imaging, and next-gen sequencing approaches to study the role of epigenetics during development. For examples of some of our recent work in this area please see:
Epigenetic regulation of hematopoiesis by DNA methylation: https://www.ncbi.nlm.nih.gov/pubmed/26814702
An epigenetic mechanism for cavefish eye degeneration: https://www.ncbi.nlm.nih.gov/pubmed/29807993
Current projects include the first-ever large-scale forward-genetic screen in a vertebrate for genetic mutants causing defects in tissue-specific epigenetic regulators. This highly successful ongoing screen uses novel transgenic epigenetic reporter lines and next-gen sequence technologies to identify novel vertebrate epigenetic regulatory factors.
The scientific environment, resources, and stipend support for this position are superb. For additional information on the Division of Developmental Biology and the Weinstein Lab, see https://science.nichd.nih.gov/confluence/display/svo/Home
Interested applicants should have a Ph.D. or M.D. and less than 3 years' postdoctoral experience. Applicants possessing both a strong biological research background and some experience with NGS data analysis (e.g., RNA-seq, ChIP-seq, Bisulfite-seq, etc.) are encouraged to apply. To apply, send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to weinsteb@mail.nih.gov and to amy.parkhurst@nih.gov
The NIH is dedicated to building a diverse community in its training and employment programs.
Fully Funded Postdoctoral Position – Computational Analysis of Development, National Institute of Child Health and Human Development (NICHD), Bethesda, MD
A fully funded postdoctoral position is available to use computational methods to study development in the zebrafish and in complementary mouse, cell culture, and cavefish models in the NICHD Division of Developmental Biology (DDB) in Bethesda, Maryland. The successful applicant will work closely with DDB investigators, primarily those within the Aquatic Models of Human Development Affinity Group including Drs. Brant Weinstein, Harold Burgess, Ajay Chitnis, Katie Drerup, and Ben Feldman, to develop and apply bioinformatic approaches to study developmental biology research topics including vascular development, developmental epigenetics, behavioral neurogenetics, collective cell migration, and neural patterning and development.
We seek either a trained biologist with strong computational/bioinformatics skills or a trained computer scientist with a strong biological interest, knowledge, and background. Candidates should have or be close to obtaining a Ph.D. or equivalent degree in bioinformatics, computational biology, computer science, molecular biology, or a closely related field. Programming skills and experience in the application of computational methods to genomic data are essential. Applicants must possess good communication skills and be fluent in both spoken and written English. The ability to learn how to use new software and quickly become expert in its use, critical thinking, problem-solving abilities, and the ability to work semi-independently are required.
The scientific environment and resources for this position are superb, including unparalleled high performance computing resources, a varied and interesting portfolio of biological research questions to develop bioinformatic tools and analysis for, expert bioinformatics training and mentoring, and highly competitive stipend support and the potential for longer-term employment.
Interested applicants should have a Ph.D., M.D., or equivalent degree and less than 3 years' postdoctoral experience. Applicants possessing both experience with NGS data analysis (e.g., RNA-seq, ChIP-seq, Bisulfite-seq, etc.) and a strong biological research background are encouraged to apply. To apply, send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to weinsteb@mail.nih.gov and to amy.parkhurst@nih.gov
The NIH is dedicated to building a diverse community in its training and employment programs.
Open Faculty Position
Graduate School of Life Science at University of Hyogo (http://www.sci.u-hyogo.ac.jp) invites applicants for a full-time Associate Professor position.
1. Position title and number of position: One Full-Time Associate Professor
2. Affiliation: Division of Biological Information, Department of Life Science, Graduate School of Life Science
3. Research field and education: The successful candidate should have an enthusiasm for the research on the field of neuroscience and/or developmental biology using zebrafish as a simple vertebrate model and is highly expected to contribute to progress in novel fields of bioscience, using molecular, genetic, physiological, imaging or other techniques. Candidates without previous experience in working with zebrafish could be also considered. The candidate will develop his/her research project in cooperation with Professor Kohei Hatta at the Laboratory of Biological Information. The educational responsibilities are i) to give lectures on neuroscience and general education courses and ii) to supervise research activities for fourth-year undergraduate students and graduate students. Some lectures are held in English.
4. Start of employment: April 1, 2019 (estimated date)
5. Qualification:
(1) Ph.D. and relevant research experience
(2) Communication skills in Japanese
6. Application documents:
(1) Detailed curriculum vitae with the applicant's photo and email address
(2) List of publications, which should be subdivided into five categories of peer-reviewed papers, review articles, books, proceedings, and others.
(3) Reprints or copies of no more than five selected papers (mark them with * in the publication list)
(4) Statement outlining previous achievements in research and education (approximately 1,000 words in total)
(5) Statement outlining future plans in research and education (approximately 1,000 words in total)
(6) List of research grants, in which Principal Investigator or Co-Investigator should be specified.
(7) Two recommendation letters, or a list of the names and contact addresses of two references.
The applicants should submit the printed paper versions of all necessary documents (1) - (6) together with a USB flash drive or a CD-ROM that contains the PDF files. Submission by email is unacceptable.
7. Application deadline: October 1, 2018
8. Selection process: Review of application forms as the primary selection and an interview including a scientific seminar and a trial lecture as the final selection. The interviewee has to pay his/her own travel expenses to attend the interview.
9. Address for application submission:
Prof. Yoshitsugu Shiro, Dean
Graduate School of Life Science, University of Hyogo
3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan
Please write “Application for Associate Professor-ship for Laboratory of Biological Information” in red on the front cover of the envelope. Application documents should be sent by registered mail. Note that the application documents will not be returned.
10. Inquiry about the position:
Prof. Kohei Hatta
Graduate School of Life Science, University of Hyogo
3-2-1 Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan
TEL: +81-791-58-0179 E-mail: khatta@sci.u-hyogo.ac.jp
Gill development, inflammation and remodelling
Throughout the lifecourse our respiratory system is exposed to a number of assaults such as pollutants (diesel particulates, nitric oxide, silica, cigarette smoke etc) and a variety of pathogens and allergens. Prolonged or repetitive insults can lead to irreversible damage of the lung. In order to address this, whilst one approach is to reduce exposure to such harmful irritants, another is to identify molecular pathways that could be targeted to improve the outcome of such damaging exposure and enhance tissue repair.
Using the zebrafish as a model organism we have found that the fish gill can be used to model the inflammatory response of mammalian lung. We have gone on to find that the zebrafish has an extremely efficient gill repair mechanism and is very resilient to injury compared to mammals which are prone to develop irreversible fibrosis consequent to similar assaults.
We have identified candidate genes that are upregulated in fish and downregulated in mammals during biological processes leading to scaring and fibrosis in mammals. The fibins fall into this category. Taking advantage of such differences between fish and mammalian systems, this project aims to discover the function of these poorly described genes (the fibins) that otherwise play a critical role in fish development.
The Dallman lab is looking for a talented and motivated PhD student to study this gene pathway. Experimental approaches will include gene cloning, imaging, gene expression analysis, transgenic fish maintenance. Funded by BBSRC and Boehringer Ingelheim the student will work closely with our industrial partners, including some visits to their sites.
Main location:
Imperial College London, Department of Life Sciences, Sir Alexander Fleming Building, South Kensington, London
Eligibility:
Candidates should hold, an Upper Second Class Honours BSc degree or better or an equivalent qualification. Candidates with a Masters degree (at Merit level or better) in addition to the BSc may be given preference. They should have a strong academic background in the biological sciences and a desire to pursue research in line with that of the research group.
Posts are open to UK nationals. EU nationals, who have spent at least 3 years prior to the application resident in the UK, are also eligible to apply. Non-UK/EU candidates are not eligible.
Funding from BBSRC and Boehringer Ingelheim will cover tuition fees for the four year duration of the studentship, contribution towards project costs, and an annual tax-free stipend at the standard Research Council rate, for 2018/2019- £16,777. This stipend will increase in line with the annual GDP deflator.
How to apply:
To apply for this position, please email a single PDF file including: a brief cover letter describing your relevant interests and research experience, your c.v. and names and contact information of three referees with the subject line “fibins PhD” to Prof Maggie Dallman and Dr Laurence Bugeon; m.dallman@imperial.ac.uk, l.bugeon@imperial.ac.uk
Recently re-opened position! A postdoctoral position is available for a highly motivated scientist to investigate genetic mediators of carcinogenesis using the zebrafish model with a focus on investigating candidate cancer-associated genes that may be essential in driving cancer initiation. Research activities will include analysis of current large-scale genetic/genomic data sets, gene overexpression and knockdown, cell transplantation, and fluorescence-based assays. Preference will be for individuals with prior experience in zebrafish microinjection, gene editing, microscopy, and genomic/RNA-seq analysis.
Please apply at https://jobs.ncsu.edu/ (Position number: 00106922) or contact Dr. Heather Shive for further information.