Postdoctoral positions are available in the Parichy lab at University of Virginia. The lab studies development using zebrafish and related species. Current emphases include hormonal control over post-embryonic neural crest stem cells, plasticity in cell state, evolution of novel cell types, and mechanisms of pattern formation and cell–cell communication within zebrafish and across Danio species. Methods include super-resolution time-lapse imaging on lab-dedicated microscopes, single cell RNA-sequencing, forward and reverse genetics, conditional manipulation of gene activity, and others. Examples of recent work include:
https://www.ncbi.nlm.nih.gov/pubmed/28209639
https://www.ncbi.nlm.nih.gov/pubmed/25170046
The Parichy lab is situated in a highly interactive department with state-of-the-art facilities and UVA has outstanding current and historical strengths in morphogenesis and pattern formation.
Applicants must have or be pursuing a Ph.D. and must have experience with modern methods of developmental biology. Prior experience with zebrafish is not required.
Applicants should submit the following to Dr. David Parichy (dparichy@virginia.edu):
• CV
• contact information for three references
• brief description of interests, experience and career goals
Applications are invited for the post of Postdoctoral Research Associate
within the Bateson Centre and the Sheffield Institute for Translational
Neuroscience (SITraN) at the University of Sheffield. We are seeking a
highly motivated scientist with experience in zebrafish research and
neurobiology to work on an exciting new, MRC-funded project which will
establish the mechanistic role of susceptibility genes for Parkinson’s
disease using mutant zebrafish (Danio rerio) lines. Funding for this
postdoctoral position is initially available for 30 months.
Genetic studies have greatly improved our understanding of monogenic forms
of Parkinson’s disease (PD), however this only accounts for 5-10% of PD.
Genome-wide association studies (GWAS) have also identified 24 risk loci in
the much more common sporadic form of PD. In the Bandmann lab we are
interested in the function of these genes that have been identified as risk
factors and have developed a large number of mutant zebrafish lines using
CRISPR/Cas9 in order to study them. Many of these genes have not previously
been studied in vertebrate models or result in embryonic lethality making
zebrafish an ideal model system in which to study them.
You will be undertaking in vivo pathway analysis on these already
established lines to determine whether these genes are involved in
pathobiological pathways linked to PD. A concept of distinct pathobiological
mechanisms contributing to PD is emerging and is centred around
mitochondrial dysfunction, autophagy/lysosomal dysfunction, and
neuroinflammation and the innate immune system. You will combine
neurophysiological, biochemical, morphological and functional analyses with
comparative, RNA-seq based transcriptomic studies to characterise these
mutants. This will establish the mechanistic role of the selected PD GWA
genes, provide new insight into the pathogenesis of PD and identify
potential drug targets.
You will have excellent skills relevant for zebrafish research along with a
PhD (or equivalent experience) and ideally also a strong background in
Neurobiology. You will join an internationally recognised research group in
a vibrant and stimulating environment within the Bateson Centre and SITraN.
This post is full time, fixed term for 30 months.
Please see for further details:
https://www.jobs.ac.uk/job/BKA885/postdoctoral-research-associate/
Informal enquiries to:
Prof Oliver Bandmann, o.bandmann@sheffield.ac.uk
A fully funded postdoctoral position in The Section on Molecular Dysmorphology in the Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, led by Dr. Forbes D. Porter MD PhD is available. The Porter laboratory uses a variety of molecular, cellular, genetic, transgenic, microscopic imaging, and next-gen sequencing approaches to study the roles of cholesterol hemostasis, and lysosomal dysfunction on development and disease progression. For examples of some of our recent work in this area please see https://www.ncbi.nlm.nih.gov/pubmed?term=(Porter F%5BAuthor%5D) AND (Eunice Kennedy Shriver National Institute of Child Health%5BAffiliation%5D AND Human Development%5BAffiliation%5D)
The scientific environment, resources, and stipend support for this position are superb. For additional information on the Porter Lab, see: https://irp.nih.gov/pi/forbes-porter
Interested applicants should have a Ph.D. or M.D. and less than 4 years' postdoctoral experience. Applicants possessing both a strong biological research background and some experience and neurobiology are strongly encouraged to apply. To apply, send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to wassifc@mail.nih.gov
The NIH is dedicated to building a diverse community in its training and employment programs.
The Division of Laboratory Animal Resources (DLAR) at the University of Pittsburgh has an opening for an Aquatics Facility Manager (position #0135537). The position oversees and directs the daily operations and management of the DLAR 10,000 tank aquatics facility including the aquatic housing systems, husbandry practices, and animal care personnel in compliance with applicable regulations, policies, and procedures.
Primary responsibilities include:
- Ensuring that institutional policies, DLAR guidance documents, AAALAC and OLAW standards, and other practices applicable to the provision of animal husbandry and care are adhered to at the facility level;
- The supervision, direction, performance management, and professional development of assigned animal care personnel;
- Ensuring that aquatic housing systems, mechanical tank washing equipment, and related facility equipment required for the daily provision of animal husbandry and care are functioning properly and maintained in good working condition and repair;
- Assessing and responding to tank water quality monitoring alarms generated by the SCADA system and communicating the nature and resolution of critical alarms to research personnel;
- Ensuring that static tank maintenance, feeding of special (non-standard) diets, tank changing procedures, and other procedures performed by research personnel are conducted in accordance with established practices and timelines;
- Maintaining a standard 80% larvae survivability for wild type zebrafish;
- Promoting effective communication and collaboration that foster and maintain productive working relationships with other DLAR leaders, investigators and research personnel, the IACUC, EH&S, and other entities involved with the animal care and use program.
Relevant education, training, experience, and skills include:
- Minimum of four years of experience in a large, shared zebrafish resource core facility managing the daily operations, supervising personnel, and supporting a variety of customers and research interests;
- Demonstrated leadership qualities including excellent interpersonal and communication (verbal and written) skills and the ability to face and resolve conflict;
- Bachelor’s Degree (required) relevant to the areas of responsibility (Master’s Degree preferred);
- Certification by the American Association for Laboratory Animal Science (AALAS) at the Laboratory Animal Technologist (LATG) level within 36 months of start date.
The review of applications will begin upon receipt and will continue until a suitable candidate is identified and the position is filled. Salary is commensurate with experience. Interested persons should apply online at https://www.pittsource.com by clicking on “Staff Positions” then entering “Aquatics Facility Manager” under Keywords.
The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer.
I am looking for a highly motivated student interested in pursuing a Ph.D. investigating the basic biology of energy homeostasis in zebrafish.
Decades of research have provided us with a good grasp of the basic biology and endocrinology of how mammals utilize energy obtained from food. However, while the basic building blocks are conserved across all vertebrates, their functional consequences appear to vary between species. For example, while mutations in Leptin or it’s receptor in mammals leads to morbid obesity, zebrafish do not share this phenotype. The successful candidate will join a junior, independent research group at the University of Cologne in Germany. The research will focus on the phenotypes and underlying mechanisms of a collection of mutant and transgenic zebrafish lines around the leptin and melanocortin signaling systems. I am looking for highly motivated candidates with a solid foundation in genetics, molecular biology and / or animal behavior. Previous experience with zebrafish is desired but not mandatory.
For further reading on the topic please see the recent Frontiers special issue I edited "https://www.frontiersin.org/research-topics/4907/comparative-studies-of-energy-homeostasis-in-vertebrates" or my website "http://www.zoologie.uni-koeln.de/michel.html?&L=1"
The Cologne Biocenter offers an excellent scientific environment for conducting research. In the last round of the German Excellence Initiative Competition of the Deutsche Forschungsgemeinschaft (DFG), the University of Cologne has been awarded the status of a “University of Excellence”, and we are associated with the Excellence Cluster for Ageing-associated Diseases (CECAD) and the Center for Molecular Medicine Cologne (DMMC). The Cologne Biocenter is located in the center of Cologne, a vibrant and multicultural city at the heart of Germany.
The University of Cologne is an equal opportunity, affirmative action and diversity supporting employer. Handicapped persons will be given preference to other equally qualified applicants. Applications from women are particularly welcome and will be preferred in case of equal qualification and capacity.
To apply, please email your detailed CV, research interests and names of two to three references to
Maximilian Michel
Postdoctoral positions are available in the Goldman Lab at the University of Michigan, Ann Arbor. Our research employs zebrafish to study central nervous system regeneration. We use the retina as a model system because it is a relatively simple part of the CNS and experimentally accessible. Our studies indicate that Muller glial cells in the retina respond to retinal injury by adopting stem cell characteristics that allow them to generate multipotent progenitors that regenerate ablated retinal neurons. Our current research is focused on understanding the molecular mechanisms underlying Muller glial cell reprogramming, investigating Muller glial cell heterogeneity, and developing transgenic zebrafish as a platform in chemical screens to identify those that can stimulate retina regeneration. Our studies rely on molecular and cell biology and take advantage of RNAseq, ATACseq, CRISPR/Cas9 gene editing, and transgenic approaches. Factors stimulating retina regeneration in fish will be tested in mice.
We seek a recent PhD that is highly motivated, bright and creative to join our group. Candidates must have demonstrated expertise (publications) in molecular and cellular biology and preference will be given to those already familiar with the retina and/or zebrafish.
Qualified candidates should send by email their CV, statement of research interests and description of past research accomplishments, along with contact information for at least 2 referees to:
Dan Goldman, PhD
Univ of Michigan, Medical Schl, 5045 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109
A postdoctoral position is available in the Lawson Lab at the University of Massachusetts Medical School. The Lawson Lab takes advantage of the zebrafish as a model system to study multiple aspects of vascular and lymphatic development. Current areas of interests include: origins of endothelial and mural cell heterogeneity, developing zebrafish as a platform to identify small molecule therapeutics, and optimization of genome editing approaches for targeted gene knock-in in zebrafish. Our efforts are supported by a recently awarded R35 grant from NHLBI that provides generous support for the next 7 years. An overview of our past and ongoing research can be found at our website (http://lawsonlab.umassmed.edu).
Applicants must be highly motivated and technically accomplished as documented by exceptional publication record. Candidates must have demonstrated experience in molecular biology. Experience with developmental model systems is preferred.
Please email CV and reprints of relevant publications to the contact information below. Applicants accepted for initial consideration will be subsequently contacted for letters of reference.
Nathan D. Lawson, PhD
Professor
Department of Molecular, Cell, and Cancer Biology
University of Massachusetts Medical School
Lazare Research Building, Room 617
364 Plantation Street
Worcester, MA 01605
e-mail: nathan.lawson@umassmed.edu
A postdoctoral position is available for a highly motivated scientist to investigate genetic mediators of carcinogenesis using the zebrafish model with a focus on investigating candidate cancer-associated genes that may be essential in driving cancer initiation. Research activities will include analysis of current large-scale genetic/genomic data sets, gene overexpression and knockdown, cell transplantation, and fluorescence-based assays. Preference will be for individuals with prior experience in zebrafish microinjection, gene editing, microscopy, and genomic/RNA-seq analysis.
Please apply at https://jobs.ncsu.edu/ (Position number: 00106922) or contact Dr. Heather Shive for further information.
Heather Shive, DVM, PhD, DACVP
1060 William Moore Drive, RB 248
NC State University, College of Veterinary Medicine
Raleigh, NC 27607
Office phone: (919) 513-6296
The Center for Developmental Biology and Regenerative Medicine in the Seattle Children¹s Research Institute and Department of Pediatrics at the University of Washington School of Medicine seeks an outstanding scientist to be appointed full-time, with preference given to candidates for appointment at the Associate or Professor level. Applicants should possess Ph.D., M.D., or M.D./Ph.D. degrees. Areas of interest are broad; these include human genetics, model organism genetics (especially zebrafish), stem cells and regeneration, computational biology, and systems level analyses of pathways involved in disease and development. The successful applicant will enjoy a competitive start-up package, and excellent space and state-of-the-art facilities in the Research Institute, which is near the University of Washington South Lake Union Campus, the Fred Hutchinson Cancer Research Center, and the Allen Brain and Cell Biology Institutes. She or he will be appointed as faculty at the University of Washington, with a potential affiliation with the Brotman Baty Institute for Precision Medicine, and will be part of a growing Center with diverse interests and expertise.
Please send a CV, a 2-3 page description of research interests and plans, and contact information for 3 letters of recommendation to:
David Beier, M.D. Ph.D.
c/o Ms. Sara Thibodeau
Center for Development Biology and Regenerative Medicine
Seattle Children¹s Research Institute
1900 Ninth Avenue, MS: C9S-5
Seattle, WA 98101-1309
Sara.Thibodeau@seattlechildrens.org
University of Washington faculty engage in teaching, research and service. The University of Washington is building a culturally diverse faculty and strongly encourages applications from female and minority candidates. The University is an Equal Opportunity Affirmative Action employer.
A neuroscience Postdoctoral Research Associate position is available in the Robles Lab at Purdue University (www.robleslab.com). We apply advanced genetic and microscopic imaging techniques to understand how the nervous system develops in larval zebrafish. We use confocal laser scanning microscopy to image the structural development of genetically targeted neurons within the intact developing brain. Multi-photon microscopy in conjunction with genetically encoded calcium sensors is employed to characterize the visual response properties of visual circuits and their constituent cell types in awake, immobilized larvae. Our major area of emphasis is developing novel, in vivo imaging assays to examine the cellular and circuit-level abnormalities underlying complex neurological disorders such as autism and epilepsy.
Candidates should have a Ph.D. in neuroscience, cell biology, genetics, or a related field. The ideal candidate will have expertise in microscopy, image analysis, and molecular biology techniques. Special consideration will be given to applicants with expertise in developing and implementing computational strategies for data/image analysis.
Please send your CV, a cover letter stating your research interests and professional goals, and the contact information for three (3) references to:
Estuardo Robles
Email: roblese@purdue.edu
Assistant Professor
Department of Biological Sciences
Purdue University
915 W State Street, LILY B-129
West Lafayette, IN, 47907
(765)494-8413