Langenau Laboratory Research Fellowship in Pediatric Cancer and Zebrafish Models
The Langenau Laboratory at Harvard Medical School and the Massachusetts General Hospital, Boston are recruiting research fellows to study mechanisms of progression and relapse in T and B cell leukemia and rhabdomyosarcoma – a tumor of muscle. Research will focus on using the zebrafish genetic model, biochemistry, and cross-species bioinformatics approaches to identify novel pathways that drive progression and relapse. Following discoveries made in the zebrafish model, work will continue in characterizing discoveries in human cell culture, primary patient samples, and mouse xenograft studies.
Dr. Langenau’s research group has become a pioneer in the field and made seminal discoveries using the zebrafish model. The laboratories interests are best summarized in the following manuscripts (Lobbardi et al., Cancer Discovery, 2017; Tang et al., JEM 2017; Moore et al., JEM, 2016; Tang et al., Nature Communications, 2016; Blackburn et al., Cancer Cell 2014; Ignatius et al., Cancer Cell 2012). Additional information about the laboratory is available at langenaulab.com.
Applicants with advanced skills in in vivo microscopy, mouse xenograft transplantation, stem cell biology, muscle development, leukemia, blood development, bioinformatic analysis, and biochemistry (including ChIP seq) are highly desired. Background in zebrafish development and/or cancer is not required.
Candidates must have PhD and/or MD, have made significant scientific contributions through publication of high impact papers, and be enthusiastic about science.
Langenau Research Group
Molecular Pathology Unit
Massachusetts General Hospital
149 Thirteenth Street, Room 6133
Charlestown, MA 02129