A new position is available within a research group (Panula group) which works on basic mechanisms in neurologic and psychiatric diseases. This particular project involves production and phenotyping new zebrafish mutants generated using the CRISPR/Cas9 method.
The group manages a very well equipped zebrafish facility, including microinjection systems, confocal and 2-photon imaging systems, systems for quantitative behavioural analysis, good facilities for molecular cloning and quantitative expression analysis (e.g. quantitative PCR, MCID4 imaging system), and well-established international collaborations. The laboratories are located in the Department of Anatomy and Neuroscience Center (HiLIFE unit) on the Meilahti medical campus of the University of Helsinki. The campus houses about 450 PIs within the areas of life sciences.
Salary will be negotiated according to qualifications and the university salary system. An initial appointment will be made for one year, with possible extension. An ideal candidate has a recent PhD in relevant area, and thorough training and experience in imaging and genome modification methods, preferably within zebrafish field. Experience in programming, molecular biology, behavioural analysis, and gene expression analysis (transgenic animals, PCR, ish, immunocytochemistry, protein chemistry), high motivation and good communication skills are needed in the multidisciplinary group. Responsibilities include research on zebrafish disease models, molecular biology, zebrafish breeding and maintenance and participation in guidance of junior group members.
Send a CV, list of publications, and an application with names and contact information of 3 references to Professor Pertti Panula, Neuroscience Center, Department of Anatomy, POB 63 (Haartmaninkatu 8), 00014 University of Helsinki, by December 1, 2017 for immediate attention. Late applications may be considered for this or related positions, but attention is not guaranteed.
Puttonen HAJ, Semenova S, Sundvik M, Panula P. Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish. Sci Rep. 2017 7:3060. doi: 10.1038/s41598-017-02981-w.
Chen YC, Semenova S, Rozov S, Sundvik M, Bonkowsky JL, Panula P. A novel developmental role for dopaminergic signaling to specify hypothalamic neurotransmitter identity. J Biol Chem. 2016 Aug 18. pii: jbc.M115.697466.
Sundvik, M., Chen, Y.-C., Panula, P.: Dynamic regulation of zebrafish histaminergic neuron population and behavior by presenilin 1. J. Neuroscience 33: 1589-1597, 2013.
Chen YC, Harrison PW, Kotrschal A, Kolm N, Mank JE, Panula P. Expression change in Angiopoietin-1 underlies change in relative brain size in fish. Proc Biol Sci. 2015 Jul 7;282. doi: 10.1098/rspb.2015.0872.
Panula, P., Chazot, P.D., Cowart, M., Gutzmer, R., Leurs, L., Liu, W.L.S., Stark, H., Thurmond, R., Haas, H.L.: International Union of Pharmacology. XCVIII. Histamine receptors. Pharmacol. Rev. 67: 601-655, 2015.