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Postdoctoral fellow in developmental biology/glycobiology
Uppsala University is an international research university focused on the development of science and education. Our most important assets are all the individuals who with their curiosity and their dedication make Uppsala University one of Sweden’s most exciting work places. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6,5 billion.
SciLifeLab (www.scilifelab.se) is a Swedish national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. SciLifeLab is hosted by four Swedish universities (Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University) and collaborates with several other universities.
SciLifeLab invites applications for Postdoc positions in the groups of our SciLifeLab Faculty.
Project description: The postdoc employed will take part in a collaborative project between Lena Kjellén at the Department of Medical Biochemistry and Microbiology and Johan Ledin at the Genome Engineering Zebrafish Facility at SciLifeLab and Uppsala University. In the project, we will apply a multiplex CRISPR/Cas9 strategy to generate zebrafish mutants where heparan sulfate sulfation varies both with regard to stage of development and localization. In addition to evaluation of the strategy, the aim is to find out how structural changes in heparan sulfate affect embryonic development. The effect of low molecular weight inhibitors of biosynthesis enzymes will also be evaluated.
Duties: Generate CRISPR/Cas9 zebrafish mutants and characterize these with regard to phenotypic changes both at organismal and molecular level. In addition to molecular biology techniques, methods for structural characterization of heparan sulfate, enzyme assays as well as advanced microscopy will be applied.
Requirements: PhD in adequate life science subject. To be eligible to apply you must have a PhD completed within three years of the application deadline. If you received your PhD earlier but special circumstances exist you are also eligible to apply. Excellent spoken and written English is required. You must be able to work both independently as well as a part of a team. Personal characteristics, such as high degree of responsibility and ability to work with others will be important selection factors.
Additional qualifications: Previous experience of working with zebrafish as a model system. Good experimental and theoretical knowledge of molecular biology techniques. Research in the glycobiology area.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Pay: Individual salaries
Starting: October 1, 2017 or as othewise agreed.
Type of employment: Temporary position for a period of two years.
Working hours: 100 %
You are welcome to submit your application no later than August 21, 2017, UFV-PA 2017/2641.
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Placement: Department of Medical Biochemistry and Microbiology
Type of employment: Full time , Temporary position longer than 6 months Pay: Fixed pay
Number of positions: 1
Working hours: 100%
County: Uppsala län
Union representative: Per Sundman, Saco-rådet 018-471 1485 Suzanne Borén Andersson, TCO/ST 018-471 6251
Ellena Papaioannou, Seko 018-471 3315
Number of reference: UFV-PA 2017/2641 Last application date: 2017-08-21