The University of Luxembourg has the following vacancy in the Luxembourg Centre for Systems Biomedicine (LCSB):
Research associate at the Aquatic Core Facility (m/f)
Fixed-term contract: 2 years, 40 h/week
Employee status
Start date: 1st October 2017
Reference: R-AGR-0356-12C
Your Role
Area: the successful applicant (m/f) will be an employee at the Luxembourg Centre for Systems Biomedicine (LCSB), a highly interdisciplinary research centre, which integrates experimental and computational biology approaches in order to understand principal mechanism of disease pathogenesis and to develop new tools in diagnosis and therapy.
Within the LCSB, the Aquatic Core Facility operates as a central platform that uses zebrafish as an in vivo disease model. This vertebrate model allows us to gain insights into the aetiology and progression of diseases, particularly of the human central nervous system, Moreover, the model enables us to perform drug screens to identify small molecules that could potentially be used for the treatment of such diseases.
Description: you will work as a research associate at the LCSB Aquatic Core Facility and will coordinate and perform zebrafish-based projects for both internal collaborators (University of Luxembourg) and external partners.
More specifically your tasks will include:
- Designing and generating knockdown models, and transgenic and mutant fish lines
- Coordinating and supporting fish-based projects (e.g. disease modelling, small molecule screens and –omics experiments)
- Coordinating basic teaching activities (e.g. trainings, workshops) offered by the Aquatic Core Facility to students and visiting scientists
- Coordinating the optimization of safe practices and animal welfare
- Supporting the daily operations and the technical aspects of the LCSB Aquatic Core Facility
Your profile
- A PhD degree in biology, molecular biology, marine biology, biomedical sciences or similar
- Experience with molecular biology (ideally Tol2 transgenesis and CRISPR/Cas9 mutagenesis) and microscopy techniques
- Working experience with animals, particularly fish species, is essential. Owning an animal laboratory science certificate (Function A required) will be considered as an advantage
- Excellent organizational, communication and management skills
- Flexible regarding short stays abroad (e.g. attendance of trainings, workshops, scientific meetings)
- Good working knowledge of English is essential. Knowledge of either German, French, or Luxemburgish will be considered as an advantage
We offer
- Opportunity to work in a modern, semi-automated aquatic facility
- A key role in cutting-edge research projects involving zebrafish (e.g. in the areas of chemical biology and systems biology)
- Opportunity to participate in the development of the platform’s research activities
- Opportunity to work in an exciting international, interdisciplinary research environment
Further Information
Applications (in English) should contain the following documents:
- A detailed Curriculum vitae
- A scan of your animal laboratory science certificate (if applicable)
- A motivation letter that includes a description of previous professional experiences
- Please ask at least two references to email their confidential letters directly to Maria Lorena Cordero Maldonado (marialorena.corderomaldonado@uni.lu) within one week of submitting the application.
Review of applications will begin immediately and will continue until the position is filled.
The University of Luxembourg is an equal opportunity employer. All applications will be treated in the strictest confidence.
Please apply online until 31st July 2017.
Only applications submitted via this link will be considered.
Identification of Novel Stress Regulators Using Zebrafish
We are seeking a highly motivated individual to join our team at the University Medical Center of the Johannes Gutenberg University Mainz in Germany. The Ryu lab has a long-standing interest in understanding the effects of stress on brain and behaviour (www.ryulab.org). In particular we are interested in the effects of the stress hormones produced by the hypothalamo-pituitary-adrenal (HPA) axis on behaviour. Although the HPA axis is the key regulatory center for the stress response regulation, the molecular mechanisms by which it can rapidly modulate behavior is currently unknown. Using an optogenetic manipulation, we recently showed hitherto unrecognized modulatory roles of the pituitary corticotroph cells on a variety of behavior directly after the onset of stress (De Marco et al., Nat. Commu. 2016, 7:12620). This work, in turn, provides a unique basis for an assay for molecules that mediate the rapid effects of the HPA axis hormones. Building upon the knowledge and tools that we developed in this work, the goal of the current project is to 1) develop a high-throughput optognetics-assisted behavioural assay to detect the rapid effects of the HPA axis on behavior and 2) use this assay to perform a genetic screen to identify novel stress response regulators. Given the striking conservation of the HPA axis among vertebrates, the molecules identified in this project will represent novel therapeutic targets for stress-induced dysfunctions in humans such as depression and anxiety disorders.
A successful candidate should possess a PhD in Neurobiology or related fields. A high-quality first author paper is a prerequisite as well as a proven record of excellence. A strong background in neurobiology, genetics and molecular biology is required. Candidates with experiences in zebrafish are preferred.
We offer a highly attractive research environment. Mainz together with nearby Frankfurt offers an exciting environment for Neuroscience with a number of excellent institutes that interact closely (www.rmn2.de). The Ryu lab is a part of a recently funded collaborative research center funded by the German Research Foundation on “Neurobiology of resilience to stress-induced dysfunctions.” The position is available starting September 2017 and is funded at the TV-L level E13 initially for two years but with a possibility for extension for up to 4 years. University Medical School of the Johannes Gutenberg University Mainz is an equal opportunity employer and female and minority candidates are strongly encouraged to apply. To apply, please send a CV, statement of research interests, and name and contact details of three referees to soojin.ryu@uni-mainz.de.
GRANT PAID JOB OPPORTUNITY
POSTING NUMBER: GPD-17025
POSTING DATE: June 28, 2017
CLOSING DATE: July 12, 2017
Technician, Zebrafish Core Facility
Medical Research Development Office
Position Summary:
The Zebrafish Core Facility supports zebrafish research within the University and serves as a national resource for zebrafish strains and biomedical aquaculture knowledge. The Facility currently houses 20,000 fish with the capability of maintaining up to 60,000. This position will be part of a family of advanced research facilities (Centralized Operations of Research Equipment and Supports, or CORES). More information about CORES can be found at: http://medicine.dal.ca/research-dal-med/facilities.html.
As a Technician in the Zebrafish Core Facility, the incumbent will be expected to provide all necessary expertise in biomedical aquaculture and management of a large and complex aquatic facility. Candidates must be willing to work shift hours, including weekends. This is a grant paid position. This position reports to the Manager of the Zebrafish Core Facility.
Requirements:
- Specific duties include: daily feeding, cleaning, breeding and maintenance of wild-type, transgenic and mutant strains.
- Screen transgenic and mutant fish lines and create new strains.
- Conduct facility tours.
- Complete a wide range of molecular techniques such as PCR and gel electrophoresis.
- Actively work with researchers to assist with experiment set up.
Qualifications: Bachelor’s degree in Biology or related field, or equivalent combination of training and experience. Experience working with aquatic systems and aquatic animals is required. Experience with zebrafish is desirable. Experience with basic plumbing and electrical would be an asset. Planning, organization, and problem solving skills are essential as is a familiarity with a wide range of computer programs such as Word, Excel, PowerPoint and FileMaker Pro.
Status: min 35 hours/week
Pay Scale: $16.50/hr ($30,030/year) plus benefits
Duration: 2 year term position (with possibility of renewal)
Start Date: ASAP
Deadline for application: July 12, 2017
Interested parties should forward a cover letter and current CV to:
Carla Ross
Carla.ross@dal.ca
Applications will be reviewed as they are received. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. We thank all applicants, however, only candidates selected for an interview will be contacted.
RESEARCH POSITION
Department: Pediatrics/Genetics
Research Associate Scholar’s position is immediately available in a genetic epidemiology for finding and characterizing susceptibility loci for type 2 diabetes and cardiovascular disease. Major foci involve large-scale genome-wide association and high-throughput sequencing diabetic families and population datasets and follow-up functional studies using transgenic Zebrafish model. Qualifications include but not limited to a graduate degree in Molecular Biology, Genetics, Biochemistry, Computational Biology, or related fields. Applicants with expertise in molecular biology, molecular genetics or cell functional studies with experience in model organisms, cell culture and/or high throughput genome analysis and familiarity for the use of statistical genetics and computational software will be preferred. Highly motivated individuals with intense interest in science and enthusiasm to understand the genetic complexities of metabolic diseases are invited to apply for this position. Candidates must be self-driven, enthusiastic, fast learner, and well organized. Must be able to multi-task and solve problems creatively and with the ability to work independently as well as in a team. Candidates with fresh Ph.D. and first-author publications in internationally recognized journals are preferred.
Position requires performing various duties including high-throughput sample preparation, SNP genotyping, microarrays, and genetic and genome-wide data analysis for genome-metabolome studies, manuscript preparation while paying strict attention to details and use of complex equipment and computer terminals. Starting salary will be commensurate with training and experience.
Please send your CV and three references to:
Dharambir K. Sanghera, PhD, FAHA
Professor of Pediatrics Genetics
University of Oklahoma Health Sciences Center
940 Stanton L. Young Blvd., Rm. 969 BMSB
Oklahoma City, OK 73104
Phone: 405-271-6026
Email: dharambir-sanghera@ouhsc.edu
A Postdoctoral Fellow position is available to study liver organogenesis, physiology and pathology in the Department of Stem Cell Biology and Regenerative Medicine at the Cleveland Clinic Lerner Research Institute. We use zebrafish as a model and focus on liver formation and disease modeling. Research projects involve genetic, biochemical and bioinformatic analysis utilizing the zebrafish model (http://www.lerner.ccf.org/stemcellbio/sakaguchi/).
We are seeking highly motivated recent graduates with a PhD and/or MD with relevant research experience. Applicants should have research experience in cell biology, molecular biology, developmental biology or a closely related field. The ideal candidate will have experience in developmental genetics.
The Lerner Research Institute provides an excellent environment for biomedical science. Our postdoctoral training program (http://www.lerner.ccf.org/education/postdoc/) provides excellent support for career development in science.
Please send your CV and contact information for three references to Takuya Sakaguchi, Ph.D. (sakagut2@ccf.org).
Postdoctoral Positions in Cardiac Development
Postdoctoral positions are available in the Waxman lab at Cincinnati Children’s Hospital Medical Center (http://www.cincinnatichildrens.org/research/divisions/m/mcb/labs/waxman/default/). Research in the Waxman Lab uses zebrafish as a model to understand the mechanisms underlying vertebrate cardiac development, with a particular interest in mechanisms that dictate overall heart as well as individual chamber size.
Applicants should be motived, creative individuals with a strong record of productivity during their graduate research. Ideal candidates will have experience or exposure to basic molecular biology, imaging, and bioinformatic techniques. Experience using zebrafish or studying development is not a requirement.
Cincinnati is a moderately-sized, extremely affordable city that is undergoing a dramatic rejuvenation.
Interested applicants should email a PDF containing their CV, a short statement of past and current research interests, and the names of at least three references to Joshua Waxman (joshua.waxman@cchmc.org).
Joshua Waxman, PhD
Assistant Professor
Molecular Cardiovascular Biology Division
Cincinnati Children’s Hospital Medical Center
Research Associate 1, MS - 44210BR
Yale University offers exciting opportunities for achievement and growth in New Haven, Connecticut. Conveniently located between Boston and New York, New Haven is the creative capital of Connecticut with cultural resources that include three major museums, a critically-acclaimed repertory theater, state-of-the-art concert hall, and world-renowned schools of Architecture, Art, Drama, and Music.
General Purpose: Function as a Lab Manager overseeing a Molecular Biology Lab using a zebrafish model system. Work on an independent research project, master generation of zebrafish mutants using CRISPR/Cas9 technique, maintain wild-type and mutant fish lines, characterize new mutant fish lines by genotypic and phenotypic analysis, supervise undergraduates and post-graduate associates in the laboratory and fish facility.
Required Education and Experience: Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.
Qualifications:
- Demonstrated knowledge and ability with zebrafish husbandry and maintenance.
- Demonstrated proficiency in molecular biology, including cloning, PCR, in vitro transcription, in situ hybridization, western blotting, and immunohistochemistry.
- Demonstrated ability in zebrafish analysis and mRNA injection.
- Demonstrated excellent interpersonal skills.
- Demonstrated strong work ethic.
- Preferred Education, Experience and Skills: Master’s Degree in the Biological Sciences, Neuroscience, Genetics or a related discipline, and one year experience or an equivalent combination of education and experience. 5 or more years of experience. Ability to lead and provide oversight in a lab setting.
Application: For more information and immediate consideration, please apply online at http://bit.ly/2txRpIY. Please be sure to reference this website when applying for this position.
We invite you to discover the excitement, diversity, rewards and excellence of a career at Yale University. One of the country's great workplaces, Yale University offers exciting opportunities for meaningful accomplishment and true growth. Our benefits package is among the best anywhere, with a wide variety of insurance choices, liberal paid time off, fantastic family and educational benefits, a variety of retirement benefits, extensive recreational facilities, and much more.
Yale University considers applicants for employment without regard to, and does not discriminate on the basis of an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression.
A postdoctoral position to study genetic causes of intracranial aneurysms is available in the laboratory of Dr. Saulius Sumanas in the Division of Developmental Biology, at the Cincinnati Children's Hospital Medical Center.
The laboratory uses the zebrafish model to validate and study mutant variants associated with intracranial aneurysms which were previously identified in human individuals. The lab also has a long standing interest in the molecular mechanisms of vascular development. We are performing screens for novel potential regulators of vasculature formation followed by their characterization and functional studies. Candidates with a strong background in developmental and molecular biology are invited to apply. Prior experience in zebrafish is helpful but not a requirement.
To apply, please send a CV and contact details of three referees to saulius.sumanas@cchmc.org
Website: http://www.cincinnatichildrens.org/research/divisions/d/dev-biology/labs/sumanas/default/
RESEARCH ASSISTANT MOLECULAR BIOLOGY
Ref: HMz/2017
The ZebraONCOfish for personalize treatment (The Zebrafish Lab), offers a research assistant position in Molecular Biology.
Eligible candidate will join a research line focused on the development of in vitro and in vivo models of metastasis and experimental/screening of new drugs in zebrafish model.
The ZebraONCOfish is a new department created by the company Ikan Biotech, with the objective of providing innovative solutions to reach a personalize oncology treatment based on the molecular and functional characterization of key steps for tumor dissemination and progression.
What we offer
1- The incorporation in The Zebrafish Lab Joint Unit (www.thezebrafishlab.com).
2- A translational research project: The Area of Oncology is configured with the aim that the clinical criteria define the basis of the research projects to rapidly revert to the patient.
3- Integration in a multidisciplinary research team: including inputs from different research fields and covering the areas of molecular and cellular biology, liquid biopsy and preclinical models.
4- Attractive scientific environment: The Zebrafish Lab, providing support to all researchers with fully equipped culture rooms, cold chambers, imaging equipment, DNA sequencing, Real-Time PCR amplification, particles analyzers, centralized spectroscopic services, MS-HPLC, Circulating Tumor Cell analysis, animal facilities, etc.
What we expect
- Applicants should hold a Master degree in biological sciences, biomedicine or any related discipline.
- Previous experience in molecular biology, biochemistry, cloning, primers design, drug discovery, RNA/DNA extraction, microscopy techniques and in vivo models (zebrafish, mouse), will be valued.
- Capacity to work in an interdisciplinary environment and be able to work in a team.
- Good oral and written communication skills in English.
Further information
Salary:
2 years; 20-22K € gross salary/ year. This contract will be supported by European Commission (SME Instrument).
Application process:
Please, email to our personnel management department: info@ikanbiotech.com including HMz/2017 and the Applicant’s full name in the subject of the message together with the following attached documents: How to apply
- CV.
- Copy of the applicant’s degree.
- 2 professional references.
- Cover Letter.
Incorporation:
Immediate incorporation is expected (September-October 2017).
No application will be eligible if all the above mentioned documents are not attached.
Deadline for applications is midnight on 15 July 2017.
The selection process will include a panel interview.
POSTDOCTORAL RESEARCH POSITION IN CANCER
Ref: HPz/2017
The Department of ZebraONCOfish at The Zebrafish Lab has an immediate opening for postdoctoral research position in cancer.
Eligible candidate will join a research line focused on the development of in vitro and in vivo models of metastasis and experimental/screening of new drugs in zebrafish model.
The ZebraONCOfish is a new department created by the company Ikan Biotech, with the objective of providing innovative solutions to reach a personalize oncology treatment based on the molecular and functional characterization of key steps for tumor dissemination and progression.
What we offer
1- The incorporation in The Zebrafish Lab Joint Unit (www.thezebrafishlab.com).
2- A translational research project: The Area of Oncology is configured with the aim that the clinical criteria define the basis of the research projects to rapidly revert to the patient.
3- Integration in a multidisciplinary research team: including inputs from different research fields and covering the areas of molecular and cellular biology, liquid biopsy and preclinical models.
4- Attractive scientific environment: The Zebrafish Lab providing support to all researchers with fully equipped culture rooms, imaging equipment, DNA sequencing, Real-Time PCR amplification, Circulating Tumor Cell analysis, animal facilities, etc.
What we expect
- Applicants must have a PhD in biomedical sciences, medicine or any related discipline. Valuable Postdoctoral experience.
- Previous research experience and publications in molecular and cellular biology, biochemistry, cell culture, microscopy techniques and live imaging, and zebrafish model will be valued.
- Experience in research or management of research programmes.
- If called upon, the ability to motivate and supervise graduate students and technical staff.
- Excellent interpersonal skills.
- The ability to work on one’s own initiative as well as in a team environment.
- Good oral and written communication skills in English.
Further information
Salary:
2 years; 30-31K € gross salary/ year. This contract will be supported by European Commission (SME Instrument).
Application process:
Please, email to our personnel management department: info@ikanbiotech.com including HPz/2017 and the Applicant’s full name in the subject of the message together with the following attached documents:
- CV
- 2 professional references.
- Cover Letter describing:
I) your prior work in animal models of cancer.
II) your experience with live imaging.
III) your short-term and long-term career goals.
Incorporation:
Immediate incorporation is expected (September-October 2017).
No application will be eligible if all the above mentioned documents are not attached.
Deadline for applications is midnight 15 July 2017
The selection process will include a panel interview.
TECHNICIAN IN ZEBRAFISH
Ref: HAz/2017
The ZebraONCOfish for personalize treatment (The Zebrafish Lab), offers a research assistant position in Cellular Biology.
Eligible candidate will join a research line focused on the development of in vitro and in vivo models of metastasis and experimental/screening of new drugs in zebrafish model.
The ZebraONCOfish is a new department created by the company Ikan Biotech, with the objective of providing innovative solutions to reach a personalize oncology treatment based on the molecular and functional characterization of key steps for tumor dissemination and progression.
What we offer
1- The incorporation in The Zebrafish Lab Joint Unit (www.thezebrafishlab.com).
2- A translational research project: The Area of Oncology is configured with the aim that the clinical criteria define the basis of the research projects to rapidly revert to the patient.
3- Integration in a multidisciplinary research team: including inputs from different research fields and covering the areas of molecular and cellular biology, liquid biopsy and preclinical models.
4- Attractive scientific environment: The Zebrafish Lab, providing support to all researchers with fully equipped culture rooms, cold chambers, imaging equipment, DNA sequencing, Real-Time PCR amplification, Circulating Tumor Cell analysis, animal facilities, etc.
What we expect
1. Applicants should hold a vocational training or degree in biological sciences.
2. Previous experience in animal care.
3. Any experience in zebrafish is an advantage.
5. Good oral and written communication skills in English will be valued.
6. Capacity to work in an interdisciplinary environment and be able to work in a team.
Further information
Salary:
2 years; 17-18K € gross salary/ year. This contract will be supported by European Commission (SME Instrument).
Application process:
Please, email to our personnel management department: info@ikanbiotech.com including HAz/2017 and the Applicant’s full name in the subject of the message together with the following attached documents: How to apply
- CV.
- Copy of the applicant’s degree.
- 2 professional references.
- Cover Letter.
Incorporation:
Immediate incorporation is expected (September-October 2017).
No application will be eligible if all the above mentioned documents are not attached.
Deadline for applications is midnight on 15 July 2017.
The selection process will include a panel interview.
RESEARCH ASSISTANT CELLULAR BIOLOGY
Ref: HCz/2017
The ZebraONCOfish for personalize treatment (The Zebrafish Lab), offers a research assistant position in Cellular Biology.
Eligible candidate will join a research line focused on the development of in vitro and in vivo models of metastasis and experimental/screening of new drugs in zebrafish model.
The ZebraONCOfish is a new department created by the company Ikan Biotech, with the objective of providing innovative solutions to reach a personalize oncology treatment based on the molecular and functional characterization of key steps for tumor dissemination and progression.
What we offer
1- The incorporation in The Zebrafish Lab Joint Unit (www.thezebrafishlab.com).
2- A translational research project: The Area of Oncology is configured with the aim that the clinical criteria define the basis of the research projects to rapidly revert to the patient.
3- Integration in a multidisciplinary research team: including inputs from different research fields and covering the areas of molecular and cellular biology, liquid biopsy and preclinical models.
4- Attractive scientific environment: The Zebrafish Lab, providing support to all researchers with fully equipped culture rooms, cold chambers, imaging equipment, DNA sequencing, Real-Time PCR amplification, Circulating Tumor Cell analysis, animal facilities, etc.
What we expect
- Applicants should hold a Master degree in biological sciences, biomedicine or any related discipline.
- Previous experience in cellular biology, biochemistry, tumor cell culture, microscopy techniques and knowledge of flow cytometric techniques, will be valued.
- Any experience in cancer and zebrafish is an advantage.
- Good oral and written communication skills in English.
- Capacity to work in an interdisciplinary environment and be able to work in a team.
Further information
Salary:
2 years; 20-22K € gross salary/ year. This contract will be supported by European Commission (SME Instrument).
Application process:
Please, email to our personnel management department: info@ikanbiotech.com including HCz/2017 and the Applicant’s full name in the subject of the message together with the following attached documents: How to apply
- CV.
- Copy of the applicant’s degree.
- 2 professional references.
- Cover Letter.
Incorporation:
Immediate incorporation is expected (September-October 2017).
No application will be eligible if all the above mentioned documents are not attached.
Deadline for applications is midnight on 15 July 2017.
The selection process will include a panel interview.
A Postdoctoral Fellow position is available immediately in The Center for the Study of Traumatic Stress at the Department of Psychiatry, Uniformed Services University (USU), Bethesda, MD. The laboratory is interested in using and developing zebrafish behavioral screening assays to investigate candidate therapeutic agents for the treatment of post-traumatic stress disorder (PTSD). The Postdoctoral Fellow will be responsible for planning, initiating and conducting experiments with zebrafish in collaboration with a multidisciplinary project team. Prior experience in zebrafish biology, behavioral studies in animal models and/or familiarity with high-throughput chemical screening assays is preferred.
Interested candidates can find more information and apply for the position at
http://careers.hjf.org/jobs/6614198-postdoctoral-fellow-laboratory
A postdoctoral position is available in the Childs lab at the University of Calgary (ucalgary.ca/childs) to study brain vessel stabilization in the context of development and aging. Techniques involve genetics, embryonic morphological analysis and imaging. Candidates with experience in computational approaches including RNAseq or fluid flow are especially encouraged to apply. Funding for this position is in place, but the candidate will be encouraged to apply for external fellowships if they are available. We have a strong preference for candidates within their first 3 years after PhD.
Our lab is part of the Alberta Children's Hospital Research Institute and has a focus on personalized medicine for pediatric disease. We are surrounded by a group of engaged model organism researchers, providing a rich training environment. Calgary is a short drive from the Rocky Mountains, providing endless recreational opportunities.
Please contact Dr. Sarah Childs at schilds@ucalgary.ca to apply. A CV, letter of interest and names of 3 references are required.
We are recruiting for a postdoc to join us for a project working on pre-clinical therapy development (mouse and zebrafish models) for spinal muscular atrophy and amyotrophic lateral sclerosis:
http://www.jobs.ac.uk/job/BBM821/postdoctoral-research-fellow/
This position offers the opportunity to contribute significantly to a major ongoing collaborative research project between Professor Tom Gillingwater and Professor Catherina Becker (see Boyd et al., 2017 PLoS Genetics, Powis et al., 2016 JCI Insight, Wishart et al., 2014 Journal of Clinical Investigation).
The position is funded by a 2-year grant award. We welcome informal enquiries: please contact Professor Tom Gillingwater (t.gillingwater@ed.ac.uk) or Prof Catherina Becker (catherina.becker@ed.ac.uk) in the first instance.
Closing date is 19 June 2017.