Postdoctoral position- The Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, invites applications for a postdoctoral position. We are seeking highly motivated candidates to join translational research projects in human and medical genetics and the development of zebrafish, mouse, and cellular models of metabolic, cardiovascular, and neurodegenerative disorders. Applicants should have an M.D. and/ or Ph.D. and a strong background in human genetics or molecular and cellular biology. Please send CV, a statement of research and career goals, and names and contact information of three references to:
PhD position available in the Aging and Muscle Metabolism Lab, University of Lausanne, Switzerland
Mitochondrial fate in aging muscle and exercise
Introduction
The University of Lausanne (UNIL) hosts 14’100 students and nearly 3’800 collaborators, professors, and researchers. Ideally situated at the banks of Lake Geneva, near Lausanne’s city center, its four campuses bring together more than 120 nationalities and are embedded in the larger, regional, vibrant life science research cluster.
Presentation
To complement the research activities in the Aging and Muscle Metabolism Lab at the Department of Physiology of the University of Lausanne, we are seeking to recruit a PhD student to work on projects relating to novel mitophagic pathways during aging, particularly looking into muscle wasting and adaptations to exercise.
Job information
Expected start date in position: as soon as possible
Contract length: 1 year, renewable
Activity rate: Full time position (approximately 50% for thesis, the rest shared among other projects & teaching)
Workplace : University of Lausanne, Department of Physiology
Your responsibilities
The main responsibility consists in conducting scientific research in the framework of the Amati lab, which is to investigate novel proteins and pathways that play a role in muscle metabolic dysfunctions that come with aging or with muscle wasting (myopathies). Mitochondria are key players in muscle metabolism and associated dysfunctions. Finely tuned dynamic modulations adapt the number of these organelles, as well as their function, location and architecture in response to external stimuli. We and others highlighted the role of mitochondria turn-over to maintain their efficiency in skeletal muscle. Autophagy-mediated degradation (referred as mitophagy) appears crucial to face muscle stimulation, stress and aging processes. The proposed project will build on findings that we have made on specific proteins and pathways that could play a role not only in aging, but also in muscular diseases such as myopathies and muscular dystrophies. The project will start on one targeted protein identified as a potentially novel mitophagic player. It will entail state of the art methodology based on multidisciplinary approaches, including clinical research, molecular biology, cellular biology and in vivo models. This project will be part of the larger mission to identify new molecular actors and pathways involved in mitochondria structuration and mitophagy. Developing zebrafish model and human primary muscle cells, we combine innovative tools to explore the functions of our hit candidates.
Of note, we are also open to new research ideas that collaborators wish to bring into the lab – with regard to both the experimental and the clinical side of the lab’s activities.
Funding for the positions is available, although application to personal, international fellowship programs will be encouraged.
Your qualifications
The ideal candidate should be a highly motivated scientist and critical thinker with a Master degree in biology or related discipline. Good team player with a solid theoretical and practical knowledge of molecular biology, cell biology and physiology. A basic knowledge of genetic model, particularly zebrafish, will be an advantage. Excellent spoken and written English is an indispensable requirement. Willingness and interest in developing a PhD thesis in the broader fields of translational research/molecular biology is a necessity.
Your benefits
The Amati lab, also known as the Aging and Muscle Metabolism lab, is hosted at the Department of Physiology at the University of Lausanne, a well-equipped and well-funded institute (https://www.unil.ch/physiologie/home.html). Our group benefits from a dynamic environment and strong collaborations embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), high end institutional facilities (cellular imaging, proteomics, electron microscopy, etc) and multiple biotech companies. We offer a nice working place in a multicultural, diversified and dynamic academic environment.
The PhD student will be enrolled in the Faculty of Biology and Medicine's doctoral school (https://www.unil.ch/ecoledoctoralefbm/en/home.html).
For informations
Lab website https://www.unil.ch/physiologie/home/menuinst/groupes-de-recherche/francesca-amati-1.html
Your application
To apply, please send a single PDF file including a motivation letter describing why you are interested in joining our group, a CV including scientific publications if applicable, your Bachelors/Masters grades, and contact details for 2 or more referees to francesca.amati@unil.ch. Please also state where you have seen the call for this position.
Deadline for application: May 30, 2017
Langenau Laboratory Research Fellowship in Pediatric Cancer and Zebrafish Models
The Langenau Laboratory at the Massachusetts General Hospital, Boston is recruiting research fellows to study mechanisms of progression and relapse in T and B cell leukemia and rhabdomysorcoma – a tumor of muscle. Research will focus on using the zebrafish genetic model, biochemistry, and cross-species bioinformatics approaches to identify novel pathways that drive progression and relapse. Following discoveries made in the zebrafish model, work will continue in characterizing discoveries in human cell culture, primary patient samples, and mouse xenograft studies.
Dr. Langenau’s research group has become a pioneer in the field and made seminal discoveries using the zebrafish model. The laboratories interests are best summarized in the following manuscripts (Tenente et al., Elife 2017; Moore et al., JEM, 2016; Tang et al., Nature Communications, 2016; Blackburn et al., Cancer Cell 2014; Tang et al., Nature Methods, 2014; Chen et al., PNAS 2014; Ignatius et al., Cancer Cell 2012). Additional information about the laboratory is available at langenaulab.com.
Applicants with advanced skills in in vivo microscopy, mouse xenograft transplantation, stem cell biology, muscle development, leukemia, blood development, bioinformatic analysis, and biochemistry (including ChIP seq) are highly desired. Background in zebrafish development and/or cancer is not required.
Candidates must have PhD and/or MD, have made significant scientific contributions through publication of high impact papers, and be enthusiastic about science.
A curriculum vitae, list of publications, and three references should be emailed as a single PDF by May 25, 2017 to dlangenau@mgh.harvard.edu and ssmith6@partners.org.
Langenau Research Group
Molecular Pathology Unit
Massachusetts General Hospital
149 Thirteenth Street, Room 6133
Charlestown, MA 02129
The Alejandro Gutierrez lab at Boston Children’s Hospital seeks a highly motivated and innovative individual to join our efforts to unravel the molecular basis of treatment-resistant cancers. This particular project is focused on genome engineering to investigate the role of ring chromosomes in sarcomagenesis, leveraging the zebrafish model of liposarcoma we previously generated.
The ideal candidate is a recent PhD graduate with strong communication, organization and interpersonal skills. Formal training in genetics, cell biology, development, or related fields would be an asset.
To apply, please email a cover letter with brief statement of research interests, a CV, and contact information for 3 references to Dr. Alejandro Gutierrez (alejandro.gutierrez@childrens.harvard.edu).
Job Title: Research Technician
Section: Microbiology
Division: Infectious Diseases
Department: Medicine
Job Family and Level: Technical Services, Level 3a
Salary Range: £30,160 - £34,270 per annum
Responsible To: Dr Serge Mostowy
Works Closely With: Other members of the group
Funding: Wellcome Trust
Location: South Kensington Campus
Contract: Full time, fixed term for 12 months
Summary of Post
This post involves supporting Dr Mostowy in his research duties, providing a high standard of technical expertise and advice. The post holder will have responsibility for experimentation and maintenance of the laboratory and zebrafish facility.
Duties and Responsibilities
- Provide up-to-date technical expertise, advice and support to a very high standard in cell biology, microbiology and molecular biology including cell culture, protein purification and analysis, recombinant DNA work and microscopy
- Work at containment level 2, with Shigella, Listeria and mycobacteria
- Work on interactions between bacteria and host cells in vitro, using tissue culture cells, and in vivo, using zebrafish
- Work closely with other scientists in the group
- Provide full laboratory management assistance to the Mostowy group, i.e. day-to-day coordination and running of the laboratory and zebrafish facility
- Coordinate and oversee laboratory staff and students in the laboratories’ research procedures, record-keeping and the requisite health and safety, Home Office, and staff development training
- Ensure that all work done in the laboratory complies with the applicable regulations concerning genetically modified organisms, biohazards, in vivo use and human tissue use, and maintain all documentation relevant to the above Home Office and other requirements
- Coordinate the purchase and invoicing of laboratory equipment and supplies and liaise with administrative staff for laboratory budget guidelines, monitoring and management
- Record and maintain data and information, as relevant and appropriate
- Contribute to the presentation of results to the group, collaborators, and to the research community in general
- Contribute to the preparation of grant reports and scientific publications
- Compliance with College policies, including financial regulations, equal opportunities, promoting race equality policy, health and safety policy, information systems security policy and intellectual property rights and register of interest policies
- Any other duties which may arise commensurate with the grade of the post
Job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
Imperial College is committed to equality of opportunity and valuing diversity.
“Using zebrafish to study the impact of gene-environment interactions in inflammatory bowel diseases”
Apply here:
https://ki.mynetworkglobal.com/en/what:job/jobID:145599/
Deadline: 2017 May 14
Description:
The environment plays a critical role triggering disease in genetically susceptible individuals. The goal of this project is to generate in vivo models to study the interaction between gene function and environmental factors during the initiation/resolution of intestinal inflammation. We have generated CRISPR mutant zebrafish lines targeting IBD-risk genes with unknown function. The successful candidate will characterize these mutants and validate her/his finding in mouse models and human organoids candidate will also generate IBD reporters to visualize immunological processes associated to IBD in the context of genetic susceptibility and environmental triggers.
Entry requirements:
Our lab has an opening for a highly creative and motivated postdoctoral scientist with an interest in mucosal immunology. We look for a candidate with proficiency and documented laboratory research experience particularly in molecular biology, in vivo imaging and genetic manipulation in zebrafish. The candidate is expected to work with both zebrafish and mouse models of intestinal inflammation. Experience in bioinformatics and RNA-seq analysis would be an advantage. The position will require independent work at the laboratory as well as extensive collaboration with other experimental groups. Fluency in both oral and written English is necessary. Documented ability to analyze and present results orally and written is important.
Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt. The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.
Publications: Villablanca EJ et al., JLB, 2008; Villablanca EJ et al., J. Immunol, 2008; Peloquin JM., et al., Annu. Rev. Immunol, 2016; Villablanca EJ., et al., Gut, 2014; Gagliani N., et al., Cell, 2014; Huber S., et al Nature, 2012; Villablanca EJ., et al., Gastroenterology, 2011; Villablanca EJ., et al., Nat. Med, 2010
More information about the Villablanca lab:
Come join our amazing team in Bethesda, MD at the Unit on Neuronal Cell Biology that pursues studies related to the cellular mechanisms of nervous system development, maintenance and function. Currently the interest is centered on the role of retrograde axonal transport of proteins and organelles in the formation and maintenance of sensory and motor axons. A variety of techniques are used including molecular and cellular biology, genetics, microscopy, and proteomics in zebrafish and cultured cells.
Responsibilities:
Assist post-docs and collaborators with research projects. Teach post-doc zebrafish reproductive physiology and care. Assist with all aspects of zebrafish related experimental design, including drafting SOPs and protocols for zebrafish related tasks and the use of the confocal microscope; statistical analysis of data; generation of publication quality images, graphs and figures. Assist with genetic mapping of identified mutants (obtain embryo, prepare DNA, perform PCR-based marker analysis).
Conduct independent research projects as directed by Principle Investigator. Provide colony management support in multiple facilities. Maintain accurate detailed records utilizing written log sheets and computer databases regarding colony, including animal breeding, health, and housing/isolator or support areas as required by Institute, facility, and/or Task officials and investigators. Manage a large scale mutagenesis screen, including generating fish lines, conducting relevant complementation testing and map-crossing and managing screen related data. Schedule screen related tasks to screen participants. Perform technical procedures related to Aquatic species (e.g. obtaining blood and other samples, obtain zebrafish sperm for cryopreservation and in vitro fertilization, facilitate animal breeding and embryo collection, and perform prescribed Veterinary treatments). Perform tissue preparation and fixation for electron microscopy. Scanning zebrafish genome for genes, mutations and viral insertions using a variety of online database. Technical and bench top duties including embryo cleaning, staging and fixation; tumor removal and imaging; mutant and transgenic identification and propagation; injection of DNA and RNA into zebrafish embryos; DNA sampling and preparation of zebrafish embryos and adults. Help screen for specific mutants.
Maintain effective lines of communication with investigator regarding colony and support duties. Actively interact with customers as required to solve customer requests, inquiries, and complaints and to provide technical assistance when applicable to job description. Manage international and domestic shipment of zebrafish embryos and adults following Federal and NIH guidelines Troubleshoot aquatic support equipment and provides input and action on cause and remedy.
Requirements:
B.S. in Biological Sciences required. Minimum four years of experience working with aquatic species in a research environment required. An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experiences listed. AALAS certification at the LATG level required.
This position offers a wide range of benefits and a very competitive salary.
Now that you’ve reviewed this amazing opportunity; if you qualify, then take that next step and apply online at http://www.criver.com Job ID 170964.
Charles River Laboratories, Inc. is an Equal Opportunity Employer M/F/Disabled/Vet
The Ganz Laboratory (www.ganzlab.org) at Michigan State University is looking to fill an immediate opening for the position of a Research Lab Technician. We are looking for an enthusiastic, highly motivated and responsible individual to join an exciting research team focused on understanding nervous system development and disease using zebrafish as model organism. The successful applicant will be involved in research using molecular, genomics and imaging techniques to understand how stem cells generate a diverse and complex nervous system during development, in the context of human disease and during regeneration.
Position summary: Our research focuses on understanding how the development and regeneration of the nervous system is regulated using zebrafish as a model organism. The ideal candidate will be expected to perform and document a variety of tasks in a timely, accurate and detailed manner, meet with the PI on a weekly basis and provide support to graduate students and postdocs in the lab. Primary duties may include, but are not limited to: perform experiments under supervision of laboratory head; provide support with molecular biology, developmental biology and imaging projects; ordering supplies and equipment; lab supply and equipment maintenance and organization; maintaining and documenting lab cleanliness and safety standards; managing lab databases (such as plasmid database, antibody database); equipment maintenance; supervising and training undergraduate students, staff and volunteers; conducting literature reviews on various topics related to developmental biology, neuroscience and genetics.
Minimum requirements: Knowledge equivalent to that which normally would be acquired by completing a four-year college degree program in Biology, Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field of biological sciences; up to six months of related and progressively more responsible or expansive work experience in a biology research lab; experience with standard molecular biology techniques; or an equivalent combination of education and experience.
Desired qualifications: Master's degree in Biology, Molecular Biology, Developmental Biology, Neuroscience or related field; one to two years post degree experience working in a molecular biology/neuroscience lab; knowledge of zebrafish biology, development, and genetics; experience with microscopy work and imaging techniques; experience with next generation sequencing approaches; strong communication and interpersonal skills; strong time management skills; strong organizational skills; evidence of experience with project planning; evidence of enthusiasm to master new techniques; evidence of accurate performance and attention to detail; evidence of successful completion of prior research goals; evidence of accurate and detailed record keeping; experience with use of various desktop computer software (Microsoft Office, Dropbox, etc.).
This is a full-time appointment, and offers excellent benefits (healthcare, dental, etc.). The initial appointment will be for a 6-month probationary period, after which yearly reappointments will be made for successful and productive candidates.
To apply please go to: https://jobs.msu.edu/ - Position number: 4909
Closing date for applications is April 25, 2017.
Job Description:
Post-graduate research associate in a basic science laboratory (www.hoffmanlab.net) studying the genetics of autism spectrum disorders (ASD) using a zebrafish model system. The appointee will assist the principal investigator in multiple aspects of the research project. These include: 1. Genotyping zebrafish carrying mutations in genes that are strongly associated with autism spectrum disorders (ASD); 2. Performing phenotyping assays to identify abnormalities in brain development and behavior in zebrafish mutants of ASD risk genes; and 3. Conducting larval behavioral assays. The post-graduate associate will gain skills in molecular biology and genetics.
Qualifications:
• Bachelor's Degree in Biological Sciences, Biochemistry, or Neuroscience
• Demonstrated record of academic achievement
• Past experience in basic science research
• Highly motivated and organized
• Strong work ethic
• GPA >3.5
• Preferred: Prior experience with zebrafish or other aquaculture experience
Application Instructions:
Send resume, cover letter describing interest in the position, unofficial transcript, and two letters of recommendation to ellen.hoffman@yale.edu.
The McMenamin Lab at Boston College is looking for a qualified and highly motivated person to serve as a technician or manager for the lab. The McMenamin lab uses highly interdisciplinary approaches answer fundamental questions about skull morphogenesis, the molecular and endocrine regulation of developmental coordination, and the evolution of life history variation in vertebrates. We use the zebrafish model to study the effects of thyroid hormone on development of the craniofacial skeleton. Over the next year, our NIH-funded lab will grow to 4-5 graduate students, technicians and postdocs and 3-7 undergraduates. Please see https://sites.google.com/a/bc.edu/mcmenamin-lab/ for more information about the lab.
Institutional Environment: Founded in 1863, Boston College is an R1 university located six miles from downtown Boston with an enrollment of 9,150 full-time undergraduates and 4,420 graduate and professional students. Ranked 31 among national universities, Boston College has 758 full-time and 1,096 FTE faculty, 2,750 non-faculty employees, an operating budget of $956 million, and an endowment in excess of $2.2 billion. The BC Biology Department supports many NIH-and NSF-funded research labs with expertise in cell and developmental biology, microbiology and immunobiology, and bioinformatics. The Department offers state-of-the-art research laboratories and core-research support facilities.
Primary responsibilities:
• Helping to manage our zebrafish colony; overseeing the schedules for feeding and husbandry; breeding and maintaining fish lines; interfacing and coordinating with the animal care facility staff
• Working closely with the PI to manage our molecular lab; ordering reagents and other supplies and maintaining laboratory equipment
• Training and supervising students in the lab
• Lab administration, including lab safety and IACUC reporting; record keeping and maintaining the lab website
• Molecular and developmental biology bench work and microscopy; data analysis; contributing to the writing and editing of publications and proposals
Requirements:
• Bachelor’s degree in Biology or a related field
• 1-2 years laboratory experience (undergraduate experience is fine, as long as it was outside of a class)
• Working knowledge of fundamental biological concepts and ability to apply knowledge in varied situations
• Excellent communications skills and attention to detail; ability to work both independently and as part of a team
Preferred Qualifications:
• MS in Biology, Developmental Biology or related field
• Experience in the zebrafish system, fluorescent microscopy, endocrinology, bioinformatics and/or molecular biology
• Experience as a supervisor
• Evidence of precise and accurate record keeping
• Highly interested in our research program and enthusiasm to master new techniques
Position: Full time position, salary will be commensurate with experience. Initially a 6 month appointment, to be renewed as appropriate.
Application: Please submit a (1) cover letter with at least 3 references, (2) CV, (3) a brief description of research interests and experience to mcmenams@bc.edu. Position is open until filled.
Women, minorities, veterans, LGBTQ and disabled individuals are particularly encouraged to apply.
Boston College conducts background checks as part of the hiring process.
The Department of Developmental Biology at Washington University School of Medicine invites applications for a Research Laboratory Manager for the Zebrafish Facility. Washington University in St. Louis is home to one of the largest and most modern zebrafish facilities in the world with robotic feeding and cleaning systems. This facility allows for large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders. The facility has almost 7,000 tanks, including a 2,000-tank nursery. The facility also has the capabilities for obtaining, viewing, and manipulating fish embryos.
We are seeking an outstanding applicant to join at the level of Research Laboratory Manager to oversee and manage the operations and the personnel of the Zebrafish Facility. The position is responsible for the smooth operation of the state-of-the art automated aquatic fish feeding system (Tritones), RO water supply system, zebrafish water recirculation systems, rotifer cultures, fish health, and bio-filtration system as well as other laboratory equipment. The applicant is expected to have a Master’s degree with 5 years’ experience in a laboratory setting or an equivalent combination of education and experience equaling 12 years. Knowledge of standard laboratory policies, procedures and equipment regarding the maintenance of zebrafish and aquatic equipment is expected. Experience with Tecniplast zebrafish systems is a plus. In addition, the candidate should have excellent communication, interpersonal and writing skills. The successful candidate will report to the head of the Department of Developmental Biology.
Interested applicants should complete a job application at the link below. Reference Job ID # 36297. http://hr.med.wustl.edu/jobs/pages/home.aspx
Washington University is an Equal Opportunity Employer AA/EOE M/F/D/V.
The Wellcome-Warwick Quantitative Biomedicine Programme Wellcome-Warwick Quantitative Biomedicine Programme was established to enhance the world-class interdisciplinary research environment at the University of Warwick by driving further development of our existing centres of excellence, including the Centre for Mechanochemical Cell Biology (www.mechanochemistry.org) and the Zeeman Institute for Systems Biology& Infectious Disease Epidemiology Research.
We are seeking to appoint three outstanding early career scientists as Assistant Professors in Quantitative Biomedicine, aiming to expand our research on cell dynamics at the molecular, cellular and/or tissue scales. We are eager to hear from candidates who are using quantitative and/or interdisciplinary approaches and have an exemplary track record in cell biology, developmental biology, structural biology, computational biology or biophysics.
Successful candidates must have a strong track record with first class publications,together with the enthusiasm and expertise to contribute to our innovative undergraduate taught programme in Interdisciplinary Science. Evidence of being able to attract funding and/or fellowships would be a further advantage. You will also contribute to the Public Engagement interface of the QBP.
Successful candidates will receive a start-up package, laboratory space in the brand new extension to our mechanochemical cell biology building, access to state-of-the-art infrastructure, including light and electron microscopy, advanced proteomics, a state-of-the-art zebrafish facility, and support from our thriving and dynamic research community.
The posts will be in the Division of Biomedical Sciences, Warwick Medical School and the successful candidates will be expected to play an active role in advancing the mission of the QBP. The posts will be subject to a five year probation period and once successfully completed, promotion to Associate Professor will follow, subject to criteria set out by the University of Warwick being met.
Potential candidates are encouraged to contact the co-Directors ofthe Wellcome Warwick Quantitative Biomedicine Programme, Profs. Mohan Balasubramanian (M.K.Balasubramanian@warwick.ac.uk) and Andrew McAinsh (A.D.McAinsh@wawick.ac.uk). Informal enquiries can also be made to Karuna Sampath (K.Sampath@warwick.ac.uk).
To be considered, please fill out an online application (see link below), including a CV, names of three expert referees who are able to comment on your readiness to embark on an independent career, a one-page cover letter and a two-page research proposal describing an exciting research program in cell dynamics.
The Ryu Lab (www.ryulab.org) at the Johannes Gutenberg University Medical Center, Mainz, Germany seeks a highly motivated postdoctoral research fellow to join our project investigating molecular mechanisms underlying stress resilience.
Why do some individuals develop diseases while others show remarkable resilience upon exposure to stressful conditions? Given the growing societal burden of stress-induced dysfunctions in humans, this question represents not only an important biological question but also addresses an urgent unmet medical need. The discovery and validation of molecular resilience mechanisms requires an animal model that has good genetic accessibility. Zebrafish offers important advantages for stress research but as of yet, there is no established model to study stress resilience. The project goal is to establish such a model and identify underlying molecular mechanisms that contribute to individual differences in stress resilience/vulnerability using the latest proteome technologies. The establishment of the resilience model is already in progress in the lab and the successful candidate will join this effort. The proteomic analyses will be carried out in collaboration with Erin Schuman’s lab at the Max Planck Institute for Brain Research in Frankfurt, Germany.
The candidate must have a PhD in neuroscience or related field, a genuine passion for neuroscience, and a deep interest in stress research. Expertise in molecular/biochemical/genomic analyses is necessary. Experience in imaging and/or behavioral analyses will be a strong plus. A strong publication record during PhD is a must.
The position is available immediately at the salary level of German Civil Servant Salary Scale of E13.
To apply, please contact Prof. Soojin Ryu (soojin.ryu@uni-mainz.de) with a heading Postdoc Application and include a CV, a list of three referees, and a motivation letter.
A full time postdoctoral research fellow position is available to do translational research in a zebrafish model of wet macular degeneration. The Principal Investigator is an energetic junior clinician scientist faculty at the Shiley Eye Institute and Department of Ophthalmology at UCSD and retinal surgeon whose laboratory focuses on interdisciplinary translational research using zebrafish to create models of retinal disease. He is enthusiastic and eager to work with individuals who share his interest in translational research to find new treatments for retinal disease, and committed to help mentor individuals toward either an academic or industry position. His biography can be found here. http://shileyeye.ucsd.edu/faculty/daniel-chao
The project involves characterization of retinal vascular phenotypes using in vivo time lapse imaging, angiography, histology, and OCT, creation of transgenic zebrafish lines, as well as execution of a small molecule screen in zebrafish embryos.
The successful candidate must have excellent written and oral communication skills, be very organized, meticulous, self-motivated, capable of working in a group/collaborative setting but with capacity for independent work.
UCSD is an exceptional scientific community with multiple labs focused on vision research at the Shiley Eye Institute. There is an outstanding zebrafish community with 4 well established zebrafish laboratories which is highly collaborative. The PI works closely with the laboratories of David Traver and Farhad Imam at UCSD.
Responsibilities of this position will include planning, execution, and presentation of experiments involving:
Zebrafish husbandry, breeding
Creation of transgenic zebrafish lines
Analysis of zebrafish retinal phenotypes using in vivo time lapse imaging, angiography, histology, and OCT
Dissociation and FACS sorting of zebrafish embryos
Gene expression and RNA Seq techniques
Molecular biology and gene editing techniques
Optimizing techniques to perform high throughput small molecule screening in zebrafish
Collaboration with other scientists in testing compounds in cell culture and rodent models of retinal disease
The qualified candidate will have earned a doctoral degree in cell biology or neurobiology, or a closely-related field, must provide proof of U.S. citizenship or current eligibility to work in the United States, and be available after July 1st, 2017 to apply. This is a full-time appointment, with occasional weekend hours for management of experiments. A 2-year minimum commitment is strongly preferred.
This is an excellent opportunity for individuals interested in future careers in translational science to gain experience in a stimulating and interactive lab environment. A competitive salary will be offered based on experience with a generous benefits package offered by UCSD School of Medicine. Enjoy living in sunny southern California in America’s finest city.
Candidates should send a letter of interest, including a one-page cover letter* (see notes below) and a curriculum vitae, to Dr. Daniel Chao at dlchao@ucsd.edu.
*In the cover letter, please briefly describe your research experience, reason(s) for seeking this position, and future career goals. Please also include some unique skills that do not make it to your CV and some personal hobbies.