Postdoctoral and PhD student position on zebrafish skin development, regeneration or carcinogenesis in Cologne, Germany A post-doctoral (E13) and a PhD student (65% E13) position are available in the laboratory of Matthias Hammerschmidt at the Biocenter of the University of Cologne, Germany, to contribute to our ongoing research on skin, fin and cutaneous appendage development, regeneration or carcinogenesis in the zebrafish. Using a combination of forward and reverse (CRISPR) genetics, transgenesis, chemical genetics, and in vivo imaging, we study different aspects of skin development, including cornification-like processes in epidermal appendages named breeding tubercles, as well as epithelial carcinogenesis and wound healing in the adult skin, including the formation and regression of scar tissue (see for instance, Richardson et al., Development 2016; Hatzold et al., eLife 2016). Several of our investigated genes are likely to be also implicated in human skin development, homeostasis or disease, and collaborations with human geneticists and dermatologists are ongoing to look into this. For further information, please visit our website (http://www.ag-hammerschmidt.zoologie.uni-koeln.de/3.html) or contact us directly via email or telephone (see below).
The Cologne Biocenter is located in the center of Cologne, and offers an excellent scientific environment for the conducted research. In the last round of the German Excellence Initiative Competition, the University of Cologne has been awarded the status of a “University of Excellence”, with our research group as part of the funded Cluster of Excellence CECAD. In addition, we are part of the Center for Molecular Medicine Cologne (CMMC) and the Collaborative Research Center (SFB829) entitled “Molecular Mechanisms regulating skin homeostasis”, with over 20 participating research groups working on different aspects of non-mammalian, mouse or human skin development and disease. In addition, Cologne is a very international and lively city, offering many opportunities for interesting leisure activities.
Postdoctoral candidates must have a Ph.D. in biology, and a strong interest in molecular and cellular developmental biology, dermatology or regeneration. Previous experience with the zebrafish and with imaging techniques is preferred, but not absolutely essential. Proficiency in English is required.
To apply, please email your detailed CV and names of two to three referees to
Matthias Hammerschmidt mhammers@uni-koeln.de; phone: ++49-221-470 5665
Cologne University, Biocenter - Room 3-502, Zuelpicher Strasse 47b,
D-50674 Koeln, Germany
Postdoctoral researcher or experienced research technicians interested in spine and cartilage development and disease research.
Positions are available in the Gray Laboratory within the Dell Pediatrics Research Institute at University of Texas at Austin Dell Medical School. The primary research focus of these positions will be to utilize novel zebrafish and cartilage cell culture models to study the genetic susceptibilities of spine and cartilage diseases. One of the major focuses of the Gray Lab is to leverage zebrafish and mouse models coupled with cell culture, transcriptomic, and proteomic approaches to understand spine and cartilage development and disease. Trainees should have proven skills working with animal models with zebrafish experience is a plus. Postdoctoral and research associate candidates should provide a cover letter, CV, and contact information for three professional references.
Send information and applications to: RYAN SCOTT GRAY, PhD Assistant Professor Department of Pediatrics Dell Medical School | The University of Texas at Austin o: 512-495-5052 | c: 512-417-7154 | ryan.gray@austin.utexas.edu
The Frazer lab at the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City seeks a 3rd post-doctoral fellow to join our group. We study lymphocyte cancers using zebrafish models and human tissue culture, with emphasis on genetic events that cause oncogenesis and therapy resistance.
An energetic, independent, and creative person would be a perfect fit for our group of 8. We like doing science, and having fun outside the lab. I am committed to mentoring junior scientists to help them achieve their career goals. Projects developed as a post-doc can be taken upon leaving the lab. Applicants should have a PhD and/or MD, and zebrafish, genetics, or molecular biology experience are a plus.
My lab belongs to the Depts. of Pediatrics, Cell Biology, and Microbiology & Immunology, and OUHSC’s Stephenson Cancer Center. We also participate in the Functional & Chemical Genomics Program at Oklahoma Medical Research Foundation. Our webpages can be found at: http://www.oumedicine.com/frazer-lab-group/frazer-lab and
http://zfin.org/action/profile/view/ZDB-LAB-081125-1
OUHSC has a large campus with graduate, medical, dental, allied-health, and other schools. Our lab is well-equipped, with great core facility access. We also have a super aquatic facility manager to handle fish care, breeding, IVF, etc., so you can focus on experiments.
Oklahoma City is the 27th largest US city (~1.3 million people) and Oklahoma's capital. It is culturally & ethnically diverse, with a low cost of living, so post-docs can live well.
Please contact me by email (kimble-frazer@ouhsc.edu) & attach your CV if you’d like to discuss the position further.
Marie Curie PhD position( ESR): Cell dynamics and genetic regulation in the zebrafish hindbrain morphogenesis
CNRS, Gif/Yvette, Paris, France
The PhD student (ESR) will be employed by CNRS.
The project involves a close interdisciplinary interaction including with the physicists and chemists. The ESR will build a mechano-genetic model to characterize the processes underlying morphogenesis and differentiation of the zebrafish hindbrain from the in vivo observation of cell behaviors, optomanipulation of signaling activities and assessment of biomechanical forces. The strategies to decipher the genetic, molecular, cellular and biomechanical processes underlying the formation of hindbrain compartments and their further differentiation from early embryonic stages (gastrulation) through neurulation (ie from 8 hpf to 24 hpf) include: i) assessing the multilevel consequences of RA signaling activation by opto-isomerisation of an inactive form of RA and monitor the role of FGF8 (optogenetic activation of FGF8 expression) in fgf8 mutants through the in vivo 3D+time imaging and automated tracking of rescued cells; ii) assess biomechanical cues through a tensorial analysis based on cell displacements, segmented cell shape and measurement of lipid droplet deformation in vivo in various genetic and environmental conditions; iii) challenge a mechanogenetic model. More formal directions could be privileged depending on the background of the applicant.
Students with background in engineering, physics, mathematics and computer science and strongly motivated to work at the interface with embryology are encouraged to apply.
For more information contact Dr. Nadine Peyriéras at nadine.peyrieras@cnrs.fr and see the web site of the laboratory (http://www.bioemergences.eu).
Marie Curie PhD position( ESR): Imaging and modelling viral infection and host response in the entire zebrafish larva
Pasteur Institute, Paris, France
The PhD student will be employed at the Institut Pasteur in Paris and will work in the group of Dr. Jean-Pierre Levraud with Dr. Emma Colucci-Guyon as co-supervisor. The PhD student will use the Sindbis virus infection model established by the group to understand how a virus propagates from organ to organ in vivo, and how the host interferon response counteracts this spread. The PhD student will use reporter systems for live imaging of the viral infection, such as viruses encoding fluorescent proteins to detect infected cells and transgenic zebrafish expressing fluorescent proteins to identify interferon-producing cells. The work will rely on already establish reporters and require the development of new systems to understand the early events that follow virus entry in cells. Co-infections with multiple viruses encoding a rainbow of colours will be imaged in the entire body for several days, revealing the path followed by viruses from cell to cell, and particularly for brain invasion. These data will be integrated into a computer model of the entire infected animal to identify the key parameters that control virus dissemination.
For more information contact Dr. Levraud at jean-pierre.levraud@pasteur.fr and see the web site of his research group (https://research.pasteur.fr/en/team/group-jean-pierre-levraud/).
Postdoctoral position in Zebrafish Vascular Biology – Skirball Institute of Biomolecular Medicine / New York University
The Torres-Vázquez lab studies the formation, remodeling and function of the vascular system at the cellular and molecular levels using zebrafish and cultured cells.
We are seeking Postdoctoral researchers interested in studying these (and other) topics:
1. Patterning of angiogenic development
2. Vascularization of the central nervous system (CNS) and blood-brain barrier (BBB) differentiation
3. Mechanisms of vessel assembly and lumenization
Position availability: late 2017, early 2018.
Links of interest: https://scholar.google.com/citations?hl=en&user=eTBw3VIAAAAJ&view_op=list_works&sortby=pubdate
Applicant qualifications:
Exceptional publication record
Experience in standard and advanced molecular biology approaches
Experience with model organisms is preferred.
Practical knowledge of genetics, cell biology, cell culture, biochemistry, bioinformatics, genomics, cell-type specific profiling of gene expression and imaging is a plus.
Please send or email CV and reprints of relevant publications to the contact information below using the subject line: Postdoctoral applicant: Your name.
We encourage applicants to outline specific research projects. Applicants accepted for initial consideration will be contacted for letters of reference.
Jesús Torres-Vázquez, Ph.D.
TYPE: Postdoctoral Position
TITLE: Research Associate (2 posts)
INSTITUTION: King’s College London, Centre for Developmental Neurobiology
CLOSING DATE: 5 Mar 2017
DESCRIPTION:
Salary Details: £32,958 per annum
Allowances: plus £2,623 London Allowance
Contract Type: Temporary/Fixed term
Contract Term: Full time
Two enthusiastic and highly motivated post-doctoral scientists are required for a Wellcome Trust funded study of the form and function of neural networks that mediate visually driven behaviours in larval zebrafish. The post holders will join the group of Dr Martin Meyer in the Centre for Developmental Neurobiology, King’s College London (https://devneuro.org/cdn/group-overview.php?groupID=67 ) and the project will make extensive use of in vivo imaging, zebrafish transgenesis and analysis of behaviour.
The post holders will be involved in developing tools and techniques for the analysis of large and complex imaging and behaviour datasets and/or will develop methods for the selective labelling and manipulation of visual circuits. The post holders will benefit from state-of-the-art imaging facilities, technical support and the intellectual environment and friendly and interactive culture of the Centre for Developmental Neurobiology.
The candidate will have, or be close to completing, a PhD and a genuine interest in neuroscience. Independence, motivation, good communication skills and a willingness to work as part of a team are required. Experience in imaging techniques, image analysis, molecular biology and zebrafish are desirable but not essential. Candidates with training and/or experience in computational or theoretical neuroscience, physics, computer science or statistical analysis of large datasets and an interest in the subject area are encouraged to apply.
This post is fixed term for 3 years.
The selection process will be a presentation and panel interview.
To apply for this post, you will need to register with the HireWire system first to download and submit the application form. The link is: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=74933
CONTACT: Dr Martin Meyer - martin.meyer@kcl.ac.uk
TYPE: Technician
TITLE: Research Technician
INSTITUTION: King’s College London, Centre for Developmental Neurobiology
CLOSING DATE: 19 Feb 2017
DESCRIPTION:
Salary Details: £23,879 per annum
Allowances: plus £2,623 London Allowance
Contract Type: Temporary/Fixed term
Contract Term: Full time
Enthusiastic Research Technician required for Wellcome Trust funded study of neural circuit function in the zebrafish visual system. The project will make extensive use of in vivo imaging and behavioural analysis in wild-type and mutant zebrafish. Would suit well organised team player keen to collaborate with and provide high quality technical assistance to other members of our research team.
A strong background in molecular biology is desirable and a genuine interest and knowledge of neuroscience, imaging techniques, and zebrafish would be helpful. The candidate will have a strong BSc or MSc and experience of working in a research laboratory. Independence, motivation, good organisational skills and a willingness to work as part of a team are essential. The candidate will benefit from state-of-the-art research facilities and the intellectual environment and interactive culture of the Centre for Developmental Neurobiology.
This is a fixed term position 3 years.
The selection process will be a panel interview.
To apply for this post, you will need to register with the HireWire system first to download and submit the application form. The link is: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=74934
CONTACT: Dr Martin Meyer - martin.meyer@kcl.ac.uk
Marie Curie PhD position( ESR): New reporters for the study of zebrafish embryo development and immune response
University of Montpellier, France
The PhD student will be employed at the University of Montpellier in France and will work in the group of Dr Georges Lutfalla with Dr. Mai Nguyen-Chi as co-supervisor. He/She will study macrophage behaviour in vivo in physiological and pathological situations. For this purpose he/she will develop new zebrafish transgenic lines expressing reporters, censors and actuators. He/She will use these tools together with a rainbow strategy to study macrophage activation both during regeneration processes and during infections by different bacterial pathogens. The project will involve implementation of new techniques of intravital microscopy including litghsheet microscopy and super-resolution. The new transgenic lines will also be used in other groups of the network to study host-pathogen interactions but also to study early development of the vertebrate embryo.
Minimum salary, 2300 €/month. The recruited PhD student will have a full social security coverage offered by University of Montpellier
For more information contact Dr Georges Lutfalla at lutfalla@univ-montp2.fr and see the web site of his research group (http://www.dimnp.univ-montp2.fr/joomla/index.php?lang=en).
University of Birmingham
College of Medical and Dental Sciences
School of Clinical and Experimental Medicine
Applications are invited from outstanding individuals with ambition to develop their independent research to work for 3.5 years under the supervision of Professor Ferenc Mueller, Professor of Developmental Genetics, on a Wellcome Trust Investigator grant. This programme is carried out in close collaboration with the computational biologist Professor Boris Lenhard at Imperial College London. The Mueller laboratory studies gene regulation in vertebrate development using interdisciplinary approaches. For recent publications and field of research see: www.birmingham.ac.uk/Ferenc-Mueller. Their research is integrated in the Birmingham Centre for Genome Biology www.birmingham.ac.uk/genome-biology.
The fellow will study how developmental regulation of genes is mediated by long-range cis-regulatory interactions. The successful candidate will combine genome wide sequencing based tools of enhancer and promoter activity profiling and apply programmable genome editing together with the power of zebrafish transgenesis to elucidate the functional consequences of predicted cis-regulatory interactions in development. The project will take advantage of the benefits of the zebrafish for imaging by high resolution in vivo microscopy.
The successful applicants will have a first degree and a PhD in an area of specialism relevant to the project. They will also have strong background in molecular biology, experience with genomics data interpretation, and/or genetic manipulation in a vertebrate model organism.
The posts are available from April for a period of 3 years (likely extendable by 6 months). Informal enquiries should be directed to Prof. Ferenc Mueller tel: +44 (0)12142895; email f.mueller@bham.ac.uk
Full time starting salary is normally in the range £29,301 to £38,183. With potential progression once in post to £40,523 a year.
Closing date: 9th March; Ref: 54650
Details from 0121 415 9000 or www.hr.bham.ac.uk/jobs HR, University of Birmingham, Edgbaston, Birmingham B15 2TT
A University of Fairness and Diversity.
Postdoctoral position
Bally-Cuif laboratory
(Institut Pasteur, Paris, France)
The laboratory of Zebrafish Neurogenetics, led by Dr. Laure Bally-Cuif at the Pasteur Institute in Paris, is seeking a highly motivated Postdoctoral Research Associate to contribute to our ongoing research on adult neurogenesis in zebrafish. We are especially interested in the molecular and cellular mechanisms underlying basic adult neural stem cell properties, including the control of their quiescence, their interactions with other neural stem cells of the germinal niche, and their recruitment towards the generation of specific neuronal identities. The analysis will involve genetic approaches, whole-mount imaging and cell tracing in the adult animal.
Candidates must have a Ph.D. in biology, and a strong interest in molecular and cellular neuroscience. Previous experience with the zebrafish and with imaging and genomic techniques is preferred. Proficiency in English is required.
The position is funded by the European Research Council and Labex Revive.
The Bally-Cuif team is one of the 16 research groups of the “Developmental and Stem Cell Biology” Department of the Pasteur Institute, focusing on evolutionary, developmental and stem cell biology in various animal models. It is also co-affiliated with the Pasteur “Neuroscience” Department.
To apply, please submit your CV and the name of three references to:
Institut Pasteur, CNRS UMR3738
Dept of Developmental and Stem Cell Biology
25 rue du Dr Roux
75015 Paris France
https://research.pasteur.fr/en/team/zebrafish-neurogenetics/
Research Lab Technician position
The Ganz Laboratory (www.ganzlab.org) at Michigan State University is looking to fill an immediate opening for the position of a Research Lab Technician. We are looking for an enthusiastic, highly motivated and responsible individual to join an exciting research team focused on understanding nervous system development and disease using zebrafish as model organism. The successful applicant will be involved in research using molecular, genomics and imaging techniques to understand how stem cells generate a diverse and complex nervous system during development, in the context of human disease and during regeneration.
Position summary: Our research focuses on understanding how the development and regeneration of the nervous system is regulated using zebrafish as a model organism. The ideal candidate will be expected to perform and document a variety of tasks in a timely, accurate and detailed manner, meet with the PI on a weekly basis and provide support to graduate students and postdocs in the lab. Primary duties may include, but are not limited to: perform experiments under supervision of laboratory head; provide support with molecular biology, developmental biology and imaging projects; ordering supplies and equipment; lab supply and equipment maintenance and organization; maintaining and documenting lab cleanliness and safety standards; managing lab databases (such as plasmid database, antibody database); equipment maintenance; supervising and training undergraduate students, staff and volunteers; conducting literature reviews on various topics related to developmental biology, neuroscience and genetics.
Minimum requirements: Knowledge equivalent to that which normally would be acquired by completing a four-year college degree program in Biology, Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field of biological sciences; up to six months of related and progressively more responsible or expansive work experience in a biology research lab; experience with standard molecular biology techniques; or an equivalent combination of education and experience.
Desired qualifications: Master's degree in Biology, Molecular Biology, Developmental Biology, Neuroscience or related field; one to two years post degree experience working in a molecular biology/neuroscience lab; knowledge of zebrafish biology, development, and genetics; experience with microscopy work and imaging techniques; experience with next generation sequencing approaches; strong communication and interpersonal skills; strong time management skills; strong organizational skills; evidence of experience with project planning; evidence of enthusiasm to master new techniques; evidence of accurate performance and attention to detail; evidence of successful completion of prior research goals; evidence of accurate and detailed record keeping; experience with use of various desktop computer software (Microsoft Office, Dropbox, etc.).
This is a full-time appointment, and offers excellent benefits (healthcare, dental, etc.). The initial appointment will be for a 6-month probationary period, after which yearly reappointments will be made for successful and productive candidates.
To apply please go to: https://jobs.msu.edu/ - Position number: 4909
Closing date for applications is February 28, 2017.
Research Fellow
The Patton lab is recruiting an enthusiastic and dedicated Postdoctoral Fellow to join a dynamic research team studying melanoma in zebrafish and mammalian systems. The Patton lab has developed a model of melanoma regression and recurrence and this post will concentrate on understanding the melanoma subpopulations that contribute to disease growth and maintenance. The post holder will use zebrafish genetics to study melanoma cell populations using single cell sequencing, RNA sequencing technologies, and live cell imaging. The post holder will be able to work well within a team, and enjoy the challenge of applying new technologies to their research. The post holder will keep current in the melanoma field, and will be expected to present their results locally and at conferences.
Closing date: 27 February 2017
Salary
The role is grade UE07 and attracts an annual salary of £32,004 to £38,183 for 35 hours each week. Salary is paid monthly by direct transfer to your Bank or Building Society account, normally on the 28th of the month. Salaries for part-time staff are calculated on the full-time scales, pro-rata to the Standard Working Week.
This post is available on a fixed term basis, with a working pattern of 35 hours per week for 24 months.
Application Procedure
All applicants should apply online Link : https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=038277
The application process is quick and easy to follow, and you will receive email confirmation of safe receipt of your application. The online system allows you to submit a CV and other attachments.
Informal enquires can be made to igmmhr@igmm.ed.ac.uk
The Goethe University Frankfurt, positioned among the top international research universities, offers a wide variety of academic programmes, a diverse group of research institutes, and a focus on interdisciplinary approaches to solving complex problems. Today, the Goethe University is the only university in Germany which enjoys significant public funding alongside administrative autonomy and the ability to create a private endowment. Situated in Germany’s most cosmopolitan and international city, the university attracts a diverse body of students and researchers from around the world and is with about 46.000 students and 4.600 employees the biggest university in Hessen.
The Group of “Neuro and Vascular Development” (Prof. Dr. Amparo Acker-Palmer) at the Goethe University Frankfurt am Main invites applications for an ERC-funded
Postdoctoral Position
(E13 TV-G-U)
This position is initially available as early as possible until December 31st, 2018.
The wage classification conforms to the job characteristics of the collective agreement applicable to the Goethe-University.
Our group is part of the Buchmann Institute for Molecular Life Sciences, of the Cluster of Excellence “Macromolecular Complexes” and of the Institute of Biosciences, located at the Campus Riedberg. The Institute is composed of nineteen scientific groups from various disciplines including biology, physics, chemistry, and medicine. We are dedicated to basic research with biomedical relevance, to train young scientists, and to develop frontier technologies in life sciences.
The Acker-Palmer Group investigates the molecular signals that coordinate the development and plasticity of the neurovascular interface. We are using a combination of state-of-the-art inducible and cell type-specific genetics, both in mouse and zebrafish, together with confocal and two-photon light microscopy, tissue explants, cell culture, proteomics and biochemical assays (see Nature Communications 6: 6576, Developmental Cell 28: 381-393, Neuron 84: 370-85, Nature 472: 356-60/478:274, Nature 465: 487–491, Nature Neuroscience 11: 1035-1043, Nature Neuroscience 10: 301-310). From our insights into basic molecular mechanisms, we hope to develop novel therapeutic strategies for the treatment of neurological and psychiatric diseases. Please visit our website www.neuro-vessel-frankfurt.de for more details on our research.
Your task:
You will work in a dynamic international team to study the neurovascular crosstalk in the zebrafish brain using genetics and state-of-the-art imaging.
Your qualifications:
We are looking for a highly motivated and experienced scientist, with a PhD in natural sciences and ideally with solid experience in neurobiology in zebrafish and in acquisition and analysis of imaging data. Good knowledge of the retinotectal pathway is preferred. Experience in molecular biology methods and zebrafish genetics, including CRISPR/Cas9 mutagenesis and Tol2 transgenesis is a plus. Excellent knowledge of the English language (spoken and written) is required.
We offer:
We offer excellent facilities to conduct cutting-edge research in an international team atmosphere. You will collaborate with internal and external partners. You will participate in tailored interdisciplinary training and a framework of common scientific activities. The laboratory is affiliated with the Max Planck Institute of Brain Research in Frankfurt through the Max Planck Fellow program.
Application:
Please submit your application, containing a cover letter that states your experience and motivation and your curriculum vitae to: bataille@bio.uni-frankfurt.de (c/o Prof. Dr. Acker-Palmer, Fachbereich Biowissenschaften, Johann Wolfgang Goethe-University Frankfurt am Main).
Women are specifically invited to apply within the frame of the equal opportunity program.The Goethe University is committed to give preference to handicapped candidates with equivalent qualifications. The limitation of the contract is based upon the regulations of the “Wissenschaftszeitvertragsgesetz” in conjunction with the “Hessischen Hochschulgesetz”.