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Postdoctoral Scientist in Fish Heart Regeneration

Department of Physiology, Anatomy and Genetics, Oxford

Grade 7: Salary in the range £31,076 - £32,004 p.a.


Applications are invited for a Postdoctoral Research Scientist to join Professor Mathilda Mommersteeg’s laboratory to work on a project focussed on identifying the mechanisms underlying fish heart regeneration using the Mexican cavefish, Astyanax mexicanus. The post would be ideally suited to a postdoctoral scientist with experience in working with fish models and background expertise in heart development or regeneration.


The successful applicant will be specifically charged with performing QTL analyses to link the ability for heart regeneration to the genome, followed by functional validation of the identified loci. The main techniques in this project will include fish cardiac injury surgery, the generation of constructs for injection to generate transgenic zebrafish and Astyanax mexicanus lines using CRISPR, oocyte injections, western blotting, qRT-PCR, immunohistochemistry and in situ hybridisation.


You must hold, or be near completion of a PhD (or equivalent) in molecular biology, biomedical sciences, genetics or a related science and have experience of working with in vivo models of development and/or cardiovascular disease.


You will be based in the Sherrington Building in the Department of Physiology, Anatomy and Genetics at the University of Oxford.


The position is funded by an ERC starting grant for up to 5 years. The post is due to start on 1 March 2017.


The closing date for applications is 12.00 noon on Monday 19 December 2016. Interviews are likely to be held early January 2017.


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