Postdoctoral position - The Karlsruhe Institute of Technology, Germany
Postdoctoral position on “molecular mechanisms controlling vascular development in the zebrafish”.
A Post-Doc position is available at The Karlsruhe Institute of Technology (KIT, Germany), Department of Cell and Developmental Biology (Director: Prof. Dr. Ferdinand le Noble), to study the molecular mechanisms controlling vascular development in zebrafish.
Vascular network remodeling and the formation of new blood vessels, angiogenesis and arteriogenesis, play an important role during embryogenesis and in the pathophysiology of ischemic cardiovascular diseases and cancer, which are most common causes of mortality in western society. Our goal is to generate novel genetic insights in the regulation of vascular development and patterning that can translate into therapeutic strategies.
We focus on several crucial aspects of vascular development including differentiation and guidance of sprouting blood vessels, the molecular cross-talk between vessels and nerves in establishing functional vascular networks, and the impact of hemodynamic factors (flow/pressure) on arterial-venous differentiation and vessel function. To address these areas of investigation, we use the zebrafish model system. We employ state of the art in vivo imaging techniques, genetic manipulation through the use of programmable nucleases, development of transgenic lines and application of small molecule screening.
Applicants must be highly motivated and technically accomplished as documented by the publication record and hold a recent PhD in a related area of study. Ideal candidates will have demonstrated experience in standard and advanced molecular biology approaches including CRISPR/Cas technology, confocal imaging and image processing, and the zebrafish model system.
The position will be available immediately. Funding will initially be provided for a period of three years (full-time) with the possibility for extension. Please send or email (merged into one PDF file) letter of motivation, CV, reprints of relevant publications, and two letters of recommendation to the contact information below.
KIT is an equal opportunity employer. Women are especially encouraged to apply. Applicants with disabilities will be preferentially considered if equally qualified.
Contact:
Prof. Dr. Ferdinand le Noble
Karlsruhe Institute of Technology (KIT)
Dept. Cell and Developmental Biology
Fritz-Haber-Weg 2
76131, Karlsruhe, Germany
email: ferdinand.noble@kit.edu
phone: +49-721-608-41670