Postdoctoral Scientist and a Ph.D. student - University of Potsdam
The Seyfried lab at the University of Potsdam,
Institute of Biochemistry and Biology is looking for a
Postdoctoral Scientist and a Ph.D. student
In our lab, we study the embryonic zebrafish heart (a relatively simple organ compared with its mammalian counterpart) to better understand the signaling events that instruct the assembly of the early heart tube. Initially, the heart consists of only the outer myocardial and inner endocardial cell layers. The endocardium is a specialized population of endothelial cells that line the interior of the heart. We would like to understand: What are the signals that regulate the morphogenesis of myocardium and endocardium? To what extent do these two tissues communicate during cardiac morphogenesis? What determines the differentiation of endocardium into its different morphological derivatives such as cushion cells? In collaboration with clinical researchers, the group uses developmental genetics combined with cell biological and pharmacological approaches to develop animal models for human cardiovascular diseases. For further details see our recent publications on these different research topics (1-3). Our lab is embedded within the Berlin biomedical research arena with many collaboration partners on Campus and within the vicinity. The lab houses a large and modern zebrafish facility and confocal and electron microscopy systems. Our group consists of an interactive and international research team.
(1) Renz, Otten et al. (2015) Regulation of β1 Integrin-Klf2-mediated angiogenesis by CCM proteins. Dev. Cell 32, 181-190.
(2) Dietrich, Lombardo et al. (2014) Blood flow and Bmp signaling control endocardial chamber morphogenesis.Dev. Cell 30, 367-377.
(3) Veerkamp et al. (2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry.Dev. Cell 24, 660-667.
More information can be found at (http://www.uni-potsdam.de/ibb/arbeitsgruppen/ordentliche-professuren/zoophysiologie/research.html)
We are looking for a highly motivated scientist and a Ph.D. student to work on these research topics. Each position is supported with initial three years of funding and the possibility of further extension. For the scientist position, we require a good publication record and extensive experience with molecular biology/biochemical methods. Previous experience with zebrafish genetics or developmental biology is of advantage. Please, send your application including your current CV and contact information for three references no later than April 15th, 2015 to Prof. Dr. Salim Seyfried (salim.seyfried@uni-potsdam.de).